Abstract
Objective
To explore the expression of caveolin-1 (CAV-1) and matrix metalloproteinase-2 (MMP-2) in bladder cancer and its clinical significance.
Methods
The expression of CAV-1 and MMP-2 were detected by the SP immunohistochemical method in 77 cases of bladder cancer.
Results
The positive rates of CAV-1, MMP-2 in bladder transitional cell carcinoma (BTCC) and bladder adenocarcinoma were significantly high than those of normal bladder mucosa, the positive rates in the deeper cancer invasion was significantly high than those of superficial bladder cancer (P < 0.01), the positive rates of CAV-1 in grades I, II and III of bladder transitional cell carcinaoma (BTCC) were 15%, 40% and 68%, respectively; the positive rates of MMP-2 in grades I, II and III of bladder transitional cell carcinoma (BTCC) were 20%, 40% and 72%, respectively (P < 0.01). CAV-1 was positive associated with MMP-2 in bladder cancer (r = 0.598, P < 0.001), but not in bladder tissue.
Conclusion
CAV-1 and MMP-2 were associated with stage and grade of bladder cancer, which suggested that CAV-1 might improve secretion of MMP-2.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ho CC, Huang PH, Huang HY, et al. Up-Regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation. Am J Pathol, 2002, 161: 1647–1656.
Joo HJ, Oh DK, Kim YS, et al. Increased expression of caveolin-1 and microvessel density correlates with metastasis and poor prognosis in clear cell renal cell carcinoma. BJU Int, 2004, 93: 291–296.
Wiechen K, Diatchenko L, Agoulnik A. Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate carcinoma suppressor. Gene Am J Pathol, 2001, 159: 1635–1643.
Abdel-Wahed MM, Asaad NY, Aleskandarany M. Expression of matrix metalloproteinase-2 in renal cell carcinoma. J Egypt Natl Canc Inst, 2004, 16: 168–177.
Galvez BG, Matias-Roman S, Yanez Mo, et al. Caveolae are a novel pathway for membrane-type 1 matrix metalloproteinase traffic in human endothelial cells. Mol Biol Cell, 2004, 15: 678–687.
Williams TM, Medina F, Badano I, et al. Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion. J Biol Chem, 2004, 279: 51630–51646.
Yang G, Truong LD, Timme TL, et al. Elevated expression of caveolin is associated with prostate and breast cancer. Clin Cancer Res, 1998, 4: 1873–1880.
Puyraimond A, Fridman R, Lemesle M, et al. MMP-2 colocalizes with caveolae on the surface of endothelial cells. Exp Cell Res, 2001, 262: 28–36.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Li, H., Chen, Y. & Yan, D. Expression of caveolin-1 and MMP-2 in bladder cancer and its clinical significance. Chin.- Ger. J. Clin. Oncol. 6, 571–573 (2007). https://doi.org/10.1007/s10330-007-0114-4
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s10330-007-0114-4