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Expression of telomerase gene and apoptosis related genes in benign and malignant breast lesion

  • Published:
The Chinese-German Journal of Clinical Oncology

Abstract

Objective

To analyse the expression of telomerase and apoptosis related protein, and explore the possible mechanism of breast cancer development.

Methods

Immunohistochemistry method (SP) was used to detect the expression of hTERT, p53 and bcl-2 in the tissues of 48 cases of human breast cancer and 42 cases of benign lesions in breast.

Results

The positive rates of expression of hTERT, p53 and bcl-2 in breast cancer were 87.50%, 56.25% and 54.17%, respectively. Compared with the groups of adjacent noncancerous and benign lesions, there was a significant difference among three types of tissues (P < 0.05). The positive rates of expression of p53 and bcl-2 in the group with positive expression of hTERT were 64.28% and 61.90%, respectively, and their difference was significant compared with the negative group (P < 0.05).

Conclusion

There is a correlation between the activation of telomerases and p53 gene mutation in the development of breast cancer, and they are perhaps relation to the down regulation of bcl-2.

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Authors and Affiliations

  1. Department of Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China

    Mengquan Li, Jingruo Li, Jing Su, Jianzhang Li & Jiangtao Li

Authors
  1. Mengquan Li
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  2. Jingruo Li
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  3. Jing Su
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  4. Jianzhang Li
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  5. Jiangtao Li
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Corresponding author

Correspondence to Mengquan Li.

Additional information

Supported by a grant from the Foundation of Health Department of Henan Province (No.20060038).

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Li, M., Li, J., Su, J. et al. Expression of telomerase gene and apoptosis related genes in benign and malignant breast lesion. Chinese German J Clin Oncol 6, 361–364 (2007). https://doi.org/10.1007/s10330-007-0056-x

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  • DOI: https://doi.org/10.1007/s10330-007-0056-x

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