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Register zur Thalamusstimulation bei Epilepsiepatienten

Erfassung von Wirksamkeit und Verträglichkeit

Registers on thalamus stimulation in epilepsy patients

Collation of efficacy and tolerability

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Zusammenfassung

Eine neuere Behandlungsalternative für pharmakorefraktäre Epilepsiepatienten stellt die tiefe Hirnstimulation (THS) dar. Aufgrund der positiven Erfahrungen mit der THS bei Bewegungsstörungen wie M. Parkinson, Tremor und Dystonien war ihre Zulassung bei Epilepsiepatienten mit erheblichen Erwartungen verbunden. Wie bei anderen Epilepsiebehandlungen wird der Erfolg der THS an den Aspekten Wirksamkeit und Verträglichkeit gemessen. Neben klinischen Studien erfolgen entsprechende Erhebungen aktuell auch in Form von Registern. Zur dauerhaften Anfallskontrolle sind hierbei Ergebnisse aus der Langzeitbeobachtung der Studie Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy (SANTE) zu erwarten. Darüber hinaus versucht das Register des deutsch-österreichischen „Arbeitskreises Tiefe Hirnstimulation bei Epilepsien“, mögliche psychiatrische und kognitive Nebenwirkung zu erfassen, während das europäische „Medtronic Registry for Epilepsy“ (MORE) der Fa. Medtronic insbesondere Responder und optimale Stimulationsparameter im Fokus hat.

Abstract

Deep brain stimulation (DBS) is a new treatment option for pharmacorefractory epilepsy patients. Due to the positive experiences gained with DBS for movement disorders such as Parkinson’s disease, Tremor und dystonia, approval for epilepsy patients was accompanied by great expectations. The success of DBS is measured by the aspects of efficacy and tolerability, as with other forms of epilepsy treatment. In addition to clinical studies such data are also currently being collated in the form of registers. Results on the long-term observation of durable seizure control are expected from the Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy (SANTE) study. Furthermore, the register of the German-Austrian “Arbeitskreis Tiefe Hirnstimulation bei Epilepsien” (working group on deep brain stimulation in epilepsy) is attempting to collect data on possible psychiatric and cognitive side effects whereas the European Medtronic Registry for Epilepsy (MORE) of the company Medtronic is focusing on responder and optimal stimulation parameters.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. B. Möller hat in der Vergangenheit Vortragshonorare und Reisekostenerstattungen von Medtronic erhalten. N. Lang hat in der Vergangenheit Vortragshonorare und Reiskostenerstattungen von Medtronic erhalten. Alle im vorliegenden Manuskript beschriebenen Untersuchungen am Menschen wurden mit Zustimmung der zuständigen Ethikkommission, im Einklang mit nationalem Recht sowie gemäß der Deklaration von Helsinki von 1975 (in der aktuellen, überarbeiteten Fassung) durchgeführt. Von allen beteiligten Patienten liegt eine Einverständniserklärung vor.

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  1. Klinik für Neurologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Haus 41, Arnold-Heller-Str. 3, 24105, Kiel, Deutschland

    B. Möller & N. Lang

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  1. B. Möller
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  2. N. Lang
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Correspondence to N. Lang.

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Möller, B., Lang, N. Register zur Thalamusstimulation bei Epilepsiepatienten. Z. Epileptol. 27, 42–47 (2014). https://doi.org/10.1007/s10309-013-0347-x

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