Advancement in bioprocess technology: parallels between microbial natural products and cell culture biologics

  • Arpan A. Bandyopadhyay
  • Anurag Khetan
  • Li-Hong Malmberg
  • Weichang Zhou
  • Wei-Shou Hu
Fermentation, Cell Culture and Bioengineering - Review


The emergence of natural products and industrial microbiology nearly eight decades ago propelled an era of bioprocess innovation. Half a century later, recombinant protein technology spurred the tremendous growth of biologics and added mammalian cells to the forefront of industrial producing cells in terms of the value of products generated. This review highlights the process technology of natural products and protein biologics. Despite the separation in time, there is a remarkable similarity in their progression. As the new generation of therapeutics for gene and cell therapy emerges, its process technology development can take inspiration from that of natural products and biologics.


Natural products Protein biologics Process technology 


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Copyright information

© Society for Industrial Microbiology and Biotechnology 2017

Authors and Affiliations

  1. 1.Department of Chemical Engineering and Materials ScienceUniversity of MinnesotaMinneapolisUSA
  2. 2.Biological Process DevelopmentBristol Myers SquibbBloomsburyUSA
  3. 3.AbbVie Bioresearch CenterWorcesterUSA
  4. 4.WuXi AppTecShanghaiChina

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