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Advancement in bioprocess technology: parallels between microbial natural products and cell culture biologics

  • Fermentation, Cell Culture and Bioengineering - Review
  • Published:
Journal of Industrial Microbiology & Biotechnology

Abstract

The emergence of natural products and industrial microbiology nearly eight decades ago propelled an era of bioprocess innovation. Half a century later, recombinant protein technology spurred the tremendous growth of biologics and added mammalian cells to the forefront of industrial producing cells in terms of the value of products generated. This review highlights the process technology of natural products and protein biologics. Despite the separation in time, there is a remarkable similarity in their progression. As the new generation of therapeutics for gene and cell therapy emerges, its process technology development can take inspiration from that of natural products and biologics.

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Authors and Affiliations

  1. Department of Chemical Engineering and Materials Science, University of Minnesota, 421 Washington Avenue SE, Minneapolis, MN, 55455-0132, USA

    Arpan A. Bandyopadhyay & Wei-Shou Hu

  2. Biological Process Development, Bristol Myers Squibb, 521 NJ-173, Bloomsbury, NJ, 08804, USA

    Anurag Khetan

  3. AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA

    Li-Hong Malmberg

  4. WuXi AppTec, Pudongxin District, Shanghai, China

    Weichang Zhou

Authors
  1. Arpan A. Bandyopadhyay
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  2. Anurag Khetan
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  3. Li-Hong Malmberg
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  4. Weichang Zhou
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  5. Wei-Shou Hu
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Correspondence to Wei-Shou Hu.

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Bandyopadhyay, A.A., Khetan, A., Malmberg, LH. et al. Advancement in bioprocess technology: parallels between microbial natural products and cell culture biologics. J Ind Microbiol Biotechnol 44, 785–797 (2017). https://doi.org/10.1007/s10295-017-1913-4

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  • DOI: https://doi.org/10.1007/s10295-017-1913-4

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