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A neural mechanism for sudden death after myocardial infarction

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Abstract.

By monitoring efferent cardiac sympathetic nerve activity (CSNA) directly in a conscious animal we observed, for the first time, that ventricular fibrillation (VF) following myocardial infarction (MI) was preceded by a paroxysm of CSNA which was not baroreflexmodulated. This observation has potential therapeutic implications.

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Authors and Affiliations

  1. Dept. of Medicine, Christchurch Hospital, Private Bag 4710, Christchurch, New Zealand

    D. L. Jardine FRACP, C. J. Charles PhD, M. D. E. Forrester BSc & M. G. Nicholls FACC

  2. Dept. of Pathology, Christchurch Hospital, Christchurch, New Zealand

    M. Whitehead FRACP

Authors
  1. D. L. Jardine FRACP
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  2. C. J. Charles PhD
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  3. M. D. E. Forrester BSc
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  4. M. Whitehead FRACP
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  5. M. G. Nicholls FACC
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Correspondence to D. L. Jardine FRACP.

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Jardine, D.L., Charles, C.J., Forrester, M.D.E. et al. A neural mechanism for sudden death after myocardial infarction. Clin Auton Res 13, 339–341 (2003). https://doi.org/10.1007/s10286-003-0109-3

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  • DOI: https://doi.org/10.1007/s10286-003-0109-3

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