Skip to main content
SpringerLink
Log in

Cancer de prostate, nutrition pauvre en polyamines et docétaxel

Prostate cancer, a low-polyamine diet and docetaxel

  • Recherche Clinique / Clinical Research
  • Published:
Oncologie

Abstract

A prospective study of the safety of the combination of a low-polyamine diet (NTL solute) and docetaxel chemotherapy in 30 patients with symptomatic, metastatic, castration-resistant prostate cancer was conducted. Chemotherapy was started after an initial three-week neoadjuvant phase of maximum polyamine depletion, and then accompanied by a progressive reduction in polyamine depletion. Patients continued with their previous treatments during the study protocol. Exclusive consumption of NTL solute with its low-polyamine level or its use in combination with docetaxel was well tolerated both on a clinical and biological level. The study protocol was well observed. Improvements in general health, nutritional status, pain, quality of life and prostate specific antigen (PSA) levels were observed.

Résumé

Étude prospective de la tolérance de l’association d’un régime à faible teneur en polyamines (soluté NTL) et d’une chimiothérapie par docétaxel chez 30 patients atteints d’un cancer de la prostate métastatique, symptomatiques, en échappement à la castration. La chimiothérapie débutait après une première phase néoadjuvante de trois semaines de déplétion maximale en polyamines, puis était accompagnée par une déplétion en polyamines progressivement décroissante. Les patients poursuivaient leurs traitements antérieurs pendant le protocole. La consommation du soluté NTL à très faible teneur en polyamines, en utilisation exclusive ou en association avec le docétaxel, a été bien tolérée aux plans clinique et biologique. L’observance a été très bonne. L’état général, le statut nutritionnel, la douleur, la qualité de vie et les taux de PSA (prostate specific antigen) ont été améliorés.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Références

  1. Aaronson NK, Ahmedzai S, Bergman B, et al. (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85: 365–376

    Article  CAS  PubMed  Google Scholar 

  2. Auvinen M, Paasinen A, Andersson LC, et al. (1992) Ornithine decarboxylase activity is critical for cell transformation. Nature 360: 355–358

    Article  CAS  PubMed  Google Scholar 

  3. Casero RA, Marton LJ (2007) Targeting polyamine metabolism and function in cancer and other proliferative diseases. Nat Rev Drug Discov 6: 373–390

    Article  CAS  PubMed  Google Scholar 

  4. Cipolla B, Bansard JY, Moulinoux JP (2008) Traitement de patients avec cancer de prostate métastatique en échappement hormonal avec un aliment diététique destiné à des fins médicales spéciales (ADDFMS) sans polyamines: étude de phases 1–2. Nutr Clin Metab 22: S118

    Google Scholar 

  5. Cipolla B, Blanchard Y, Chamaillard L, et al. (1996) In vivo, synergestic inhibition of MAT-LyLu rat prostatic adenocarcinoma growth by polyamine deprivation and low-dose cyclophosphamide. Urol Res 24: 93–99

    Article  CAS  PubMed  Google Scholar 

  6. Cipolla B, Havouis R, Moulinoux JP (2007) Polyamine contents in current foods: a basis for polyamine reduced diet and a study of its long-term observance and tolerance in prostate carcinoma patients. Amino Acids 33: 203–212

    Article  CAS  PubMed  Google Scholar 

  7. Cipolla BG, Havouis R, Moulinoux JP (2010) Polyamine reduced diet (PRD) nutrition therapy in hormone refractory prostate cancer patients. Biomed Pharmacother 64: 363–368

    Article  CAS  PubMed  Google Scholar 

  8. Cipolla, B, Guillé F, Moulinoux JP (2003) Polyamine-reduced diet in metastatic hormone-refractory prostate cancer patients. Biochem Soc Trans 31: 384–387

    Article  CAS  PubMed  Google Scholar 

  9. Ferrier J, Bayet-Robert M, Pereira B, et al. (2011) Impact of a polyamine-deficient diet on the prevention of acute nociceptive disorders induced by oxaliplatin in rat. Bull Cancer 98: S92–S93

    Google Scholar 

  10. Haute Autorité de santé (2005) Avis de la Commission de transparence: taxotère

    Google Scholar 

  11. Heby O, Holm I, Frostesjö L, et al. (1992) Polyamines in the gastrointestinal tract. In: Dowling RH, Fölch UR, Löser C (eds) Polyamines: regulators of mammalian cell growth and differentiation. Kluwer Academic Publisher, Dordrecht Holland, pp. 19–28

    Google Scholar 

  12. Heby O, Sarna GP, Marton LJ, et al. (1973) Polyamine content of AKR leukemic cells in relation to the cell cycle. Cancer Res 33: 2959–2964

    CAS  PubMed  Google Scholar 

  13. Jänne J, Pösö H, Raina A (1978) Polyamines in rapid growth and cancer. Biochim Biophys Acta 473: 241–293

    PubMed  Google Scholar 

  14. Kergozien S, Bansard JY, Delcros JG, et al. (1996) Polyamine deprivation provokes an antalgic effect. Life Sci 58: 2209–2215

    Article  CAS  PubMed  Google Scholar 

  15. Latorzeff I, Esterni B, Habibian M, et al. (2010) Safety results of a phase III trial evaluating ADT + docetaxel versus ADT alone in hormone-naïve meta6 flacons NTL + static prostate cancer patients (GETUG-AFU 15/0403). J Clin Oncol 28: 15s

    Google Scholar 

  16. Latremolière A, Woolf CJ (2009) Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain 10: 895–926

    Article  PubMed Central  PubMed  Google Scholar 

  17. Loftis JM, Janowsky A (2003) The Nmethyl-D-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implications. Pharmacol Ther 97: 55–85

    Article  CAS  PubMed  Google Scholar 

  18. Mechulam A, Chernov KG, Mucher E, et al. (2009) Polyamine sharing between tubulin dimers favours microtubule nucleation and elongation via facilitated diffusion. PLoS Comput Biol 5: e1000255

    Article  PubMed Central  PubMed  Google Scholar 

  19. Mony L, Zhu S, Carvalho S, et al. (2011) Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines. EMBO J 30: 3134–3146

    Article  CAS  PubMed  Google Scholar 

  20. Moulinoux JP, Darcel F, Quemener V, et al. (1991) Inhibition of the growth of U-251 human glioblastoma in nude mice by polyamine deprivation. Anticancer Res 11: 175–179

    CAS  PubMed  Google Scholar 

  21. Moulinoux JP, Quemener V, Cipolla B, et al. (1991) The growth of MAT-LyLu rat prostatic adenocarcinoma can be prevented in vivo by polyamine deprivation. J Urol 146: 1408–1412

    CAS  PubMed  Google Scholar 

  22. Petrylak DP, Tangen CM, Hussain MH, et al. (2004) Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med 351(15): 1513–1520

    Article  CAS  PubMed  Google Scholar 

  23. Pohjanpelto P, Virtanen I, Holtta E (1981) Polyamine starvation causes disappearance of actin filaments and microtubules in polyamine-auxotrophic CHO cells. Nature 293: 475–477

    Article  CAS  PubMed  Google Scholar 

  24. Ransom RW, Stec NL (1988) Cooperative modulation of [3H]MK-801 binding to the N-methyl-D-aspartate receptor-ion channel complex by L-glutamate, glycine, and polyamines. J Neurochem 51: 830–836

    Article  CAS  PubMed  Google Scholar 

  25. Reynolds IJ, Rothermund KD (1995) Characterization of the effects of polyamines on the modulation of the N-methyl-D-aspartate receptor by glycine. Neuropharmacology 34: 1147–1157

    Article  CAS  PubMed  Google Scholar 

  26. Rivat C, Richebé P, Laboureyras E, et al. (2008) Polyamine deficient diet to relieve pain hypersensitivity. Pain 137: 125–137

    Article  CAS  PubMed  Google Scholar 

  27. Seiler N, Sarhan S, Grauffel C, et al. (1990) Endogenous and exogenous polyamines in support of tumor growth. Cancer Res 50: 5077–5083

    CAS  PubMed  Google Scholar 

  28. Tannock IF, Osoba D, Stockler M R, et al. (1999) Chemotherapy with mitoxantrone plus prednisolone or prednisolone alone for symptomatic hormone-resistant prostate cancer: a Canadian randomized trial with palliative end points. J Clin Oncol 14: 1756–1764

    Google Scholar 

  29. Tannock IF, De Wit R, Berry WR, et al. (2004) Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med 351: 1502–1512

    Article  CAS  PubMed  Google Scholar 

  30. Yamamoto T, Yaksh TL (1992) Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists. Pain 49: 121–128

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Service d’urologie, centre hospitalier privé, 6, boulevard de la Boutière, F-35760, Saint-Grégoire, France

    B. Cipolla

  2. GRETAC, université Rennes-I, F-35000, Rennes, France

    B. Cipolla & J. -P. Moulinoux

  3. Service d’oncologie et radiothérapie, centre hospitalier privé, 6, boulevard de la Boutière, F-35760, Saint-Grégoire, France

    L. Miglianico & X. Artignan

  4. Service de nutrition, centre hospitalier privé, 6, boulevard de la Boutière, F-35760, Saint-Grégoire, France

    D. Bligny & C. Abraham

Authors
  1. B. Cipolla
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. Miglianico
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. Bligny
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. X. Artignan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C. Abraham
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. -P. Moulinoux
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to B. Cipolla.

About this article

Cite this article

Cipolla, B., Miglianico, L., Bligny, D. et al. Cancer de prostate, nutrition pauvre en polyamines et docétaxel. Oncologie 15, 555–563 (2013). https://doi.org/10.1007/s10269-013-2260-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10269-013-2260-3

Keywords

Mots clés

Search

Navigation