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Cancers secondaires des radiothérapies

Second malignancies following radiation therapy

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  • Published:
Oncologie

Résumé

Depuis maintenant plus de 20 ans, on assiste á une augmentation réulière de la survie des patients après le diagnostic d’un cancer. Malgré les efforts pour cibler leur action sur les cellules cancéreuses, la chimiothérapie et la radiothérapie atteignent les tissus sains et ont des effets cancérogènes sur ces tissus. L’étude des cancers secondaires aux radiothérapies a fait l’objet d’un grand nombre d’études, avec ou sans estimation de la dose de radiation reçue à leur siège, mais les résultats sont sou-vent contradictoires. Il n’existe tou-jours pas de modèle capable de prédire le risque de cancer secondaire associé à une radiothérapie donnée, ce qui implique qu’on ne peut anticiper les conséquences des techniques nouvelles de radiothérapie telles que l’IMRT.

Abstract

For more than 20 years, cancer survival rates have been increasing. In spite of efforts to target only cancerous cells, chemotherapy and radiotherapy reach healthy tissue and have carcinogenic effects. A large number of studies, with and without precise dosimetric evaluations, have investigated malignancies secondary to radiation therapy, but their results have often been contradictory. There is still no model able to predict the risk of secondary cancer associated with a given radiotherapy, implying that it is impossible to anticipate the consequences of new radiotherapy techniques such as IMRT.

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Abbreviations

IMRT:

radiothérapie par modulation d’intensité

RR:

Risque Relatif

ERR:

Excès de risque relatif

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Authors and Affiliations

  1. Inserm U605, F-94800, Villejuif, France

    F. de Vathaire, N. Haddy & I. Diallo

  2. Institut Gustave-Roussy, 39, rue Camille-Desmoulins, F-94800, Villejuif, France

    F. de Vathaire, N. Haddy & I. Diallo

  3. Université Paris-XI, F-94800, Villejuif, France

    F. de Vathaire, N. Haddy & I. Diallo

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  1. F. de Vathaire
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  2. N. Haddy
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  3. I. Diallo
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Correspondence to F. de Vathaire.

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de Vathaire, F., Haddy, N. & Diallo, I. Cancers secondaires des radiothérapies. Oncologie 9, 352–360 (2007). https://doi.org/10.1007/s10269-007-0644-y

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