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Association between periodontitis and chronic migraine: a case–control study

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Abstract

The aim of this investigation was to examine whether chronic periodontitis (CP) is a risk indicator of chronic migraine (CM). We performed a case–control study consisted of 102 cases (patients diagnosed with CM) and 91 controls (non-CM individuals) matched by age and gender. Full-mouth periodontal charts, demographic, medical, clinical, as well as neurological data were obtained. In addition, high sensitive C-reactive protein serum levels were determined from blood samples of both cases (taken during migraine interictal period) and controls. The prevalence of CP was significantly higher in patients with CM compared to those without CM (58.8 vs. 30.8%, p < 0.0001). Logistic regression analysis showed that CP was significantly associated with the presence of CM, independently of well-known chronifying factors of migraine (OR 2.4; 95% CI 1.2–4.7; p = 0.012). Based on our results, CP could be considered as a risk indicator of CM. However, more evidence is necessary to investigate if this relationship is causal or not.

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Acknowledgements

Y. Leira is supported by a fellowship from the Health Research Institute of Santiago de Compostela (IDIS) and is the recipient of the 2017 SEPA-Sunstar International Training Grant.

Funding

This study was partially supported by grants from the Spanish Ministry of Economy and Competitiveness—Institute of Health Carlos III (PI15/01578). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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    Authors and Affiliations

    1. Periodontology Unit, Faculty of Medicine and Odontology, University of Santiago de Compostela, Rúa Entrerríos S/N, 15782, Santiago de Compostela, Spain

      Pablo Ameijeira, Yago Leira & Juan Blanco

    2. Odontología Médico-Quirúrgica (OMEQUI) Research Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain

      Yago Leira & Juan Blanco

    3. Headache Unit, Department of Neurology, Hospital Clínico Universitario, University of Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain

      Clara Domínguez & Rogelio Leira

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    1. Pablo Ameijeira
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    2. Yago Leira
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    4. Rogelio Leira
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    Correspondence to Yago Leira.

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    The authors declare that they have no conflicts of interest in relation to this paper.

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    All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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    Informed consent was obtained from all individual participants included in the study.

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    Pablo Ameijeira and Yago Leira have contributed equally to the study.

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    Ameijeira, P., Leira, Y., Domínguez, C. et al. Association between periodontitis and chronic migraine: a case–control study. Odontology 107, 90–95 (2019). https://doi.org/10.1007/s10266-018-0360-7

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    • DOI: https://doi.org/10.1007/s10266-018-0360-7

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