Statistical Methods and Applications

, Volume 16, Issue 3, pp 321–346 | Cite as

A numerical study for comparing two response-adaptive designs for continuous treatment effects

  • Anna Maria Paganoni
  • Piercesare SecchiEmail author
Original Article


We study two sequential, response-adaptive randomized designs for clinical trials; one has been proposed in Bandyopadhyay and Biswas (Biometrika 88: 409–419, 2001) and in Biswas and Basu (Sankhya Ser B 63:27–42, 2001), the other stems from the randomly reinforced urn introduced and studied in Muliere et al. (J Stat Plan Inference 136:1853–1874, 2006a). Both designs can be used in clinical trials where the response from each patient is a continuous variable. Comparison is conducted through numerical studies and along a new guideline for the evaluation of a response-adaptive design.


Response adaptive designs Clinical trials Urn schemes 


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Dipartimento di Matematica “F. Brioschi”Politecnico di MilanoMilanoItaly

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