Acta Mathematicae Applicatae Sinica, English Series

, Volume 19, Issue 3, pp 447–458 | Cite as

Some Results on Two-stage Clinical Trials

  • Yu-ming Chen
  • Gui-jing Chen
  • Zhi-dong Bai
  • Fei-fang Hu
Original papers


Among a variety of adaptive designs, stage-wise design, especially, two-stage design is an important one because patient responses are not available immediately but are available in batches or intermittently in some situations. In this paper, by Bayesian method, the general formula of asymptotical optimal worth is given, meanwhile the length of some optimal designs at first stage concerning two-stage trials in several important cases has been obtained.


Adaptive design two-stage method Bayesian method optimal stopping time clinical trials 

2000 MR Subject Classification

62K05 62L05 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Yu-ming Chen
    • 1
  • Gui-jing Chen
    • 1
  • Zhi-dong Bai
    • 2
  • Fei-fang Hu
    • 2
  1. 1.Dapartment of MathematicsAnhui UniversityHefeiChina
  2. 2.Dapartment of Statistics & Applied ProbabilityNUSSingapore

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