Vesicle adhesion reveals novel universal relationships for biophysical characterization
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Adhesion plays an integral role in diverse biological functions ranging from cellular transport to tissue development. Estimation of adhesion strength, therefore, becomes important to gain biophysical insight into these phenomena. In this study, we use curvature elasticity to present non-intuitive, yet remarkably simple, universal relationships that capture vesicle–substrate interactions. These relationships not only provide efficient strategies to tease out adhesion energy of biological molecules but can also be used to characterize the physical properties of elastic biomimetic nanoparticles. We validate the modeling predictions with experimental data from two previous studies.
KeywordsLipid membranes Vesicle adhesion Adhesion energy Nanoparticle stiffness
This study was funded by NSF Grants CMMI 1437330 and CMMI 1562043.
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Conflicts of interest
The authors declare that they have no conflict of interest.
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