Biomechanics and Modeling in Mechanobiology

, Volume 17, Issue 1, pp 103–109 | Cite as

Vesicle adhesion reveals novel universal relationships for biophysical characterization

  • Ehsan Irajizad
  • Ashutosh Agrawal
Original Article


Adhesion plays an integral role in diverse biological functions ranging from cellular transport to tissue development. Estimation of adhesion strength, therefore, becomes important to gain biophysical insight into these phenomena. In this study, we use curvature elasticity to present non-intuitive, yet remarkably simple, universal relationships that capture vesicle–substrate interactions. These relationships not only provide efficient strategies to tease out adhesion energy of biological molecules but can also be used to characterize the physical properties of elastic biomimetic nanoparticles. We validate the modeling predictions with experimental data from two previous studies.


Lipid membranes Vesicle adhesion Adhesion energy Nanoparticle stiffness 



This study was funded by NSF Grants CMMI 1437330 and CMMI 1562043.

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.Department of Mechanical EngineeringUniversity of HoustonHoustonUSA

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