Vesicle adhesion reveals novel universal relationships for biophysical characterization
- 173 Downloads
Adhesion plays an integral role in diverse biological functions ranging from cellular transport to tissue development. Estimation of adhesion strength, therefore, becomes important to gain biophysical insight into these phenomena. In this study, we use curvature elasticity to present non-intuitive, yet remarkably simple, universal relationships that capture vesicle–substrate interactions. These relationships not only provide efficient strategies to tease out adhesion energy of biological molecules but can also be used to characterize the physical properties of elastic biomimetic nanoparticles. We validate the modeling predictions with experimental data from two previous studies.
KeywordsLipid membranes Vesicle adhesion Adhesion energy Nanoparticle stiffness
This study was funded by NSF Grants CMMI 1437330 and CMMI 1562043.
Compliance with ethical standards
Conflicts of interest
The authors declare that they have no conflict of interest.
- Alberts B (2008) Molecular biology of the cell, vol 1. Garland Science, New YorkGoogle Scholar
- Aplin A, Howe A, Alahari S, Juliano R (1998) Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins. Pharmacol Rev 50(2):197Google Scholar
- Helfrich W (1973) Elastic properties of lipid bilayers: theory and possible experiments. Zeitschrift für Naturforschung C 28(11–12):693Google Scholar
- Shampine LF, Kierzenka J, Reichelt MW (2000) Solving boundary value problems for ordinary differential equations in MATLAB with bvp4c. Tutor Notes 2000:1Google Scholar
- Ursell T. Stretching the definition of a lipid bilayer: elasticity role in protein and lipid organization. Ph.D. thesis, Caltech, CaltechETD:etd-06062009-131454 (2009)Google Scholar