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Induction therapy of basiliximab versus antithymocyte globulin in renal allograft: a systematic review and meta-analysis

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Abstract

Objective

The aim of this meta-analysis was to evaluate the efficacy of basiliximab versus antithymocyte globulin for induction therapy in renal allograft.

Methods

Medline (PubMed), Embase, Ovid, Cochrane, and the Chinese Biomedical Literature databases were searched to identify prospective randomized controlled trials that compared basiliximab with antithymocyte globulin (ATG) for induction therapy in renal transplantation. RevMan 5.1 software and Stat Manager V4.1 software were used for the meta-analysis.

Results

Eight RCTs were included, including a total of 1153 patients. Of these, 547 (47%) had received basiliximab, and 606 (53%) had received ATG. The pooled results revealed that the basiliximab had a lower rate of neoplasm compared with ATG [odds ratio (OR) 0.26; 95% confidence interval (CI) 0.08–0.78; P = 0.02]. There were no significant differences between the two drugs regarding 1-year acute rejection rate (OR 1.32; 95% CI 0.93–1.87; P = 0.13), 1-year graft survival rate (OR 0.73; 95% CI 0.45–1.18; P = 0.20), 1-year patient survival rate (OR 0.52; 95% CI 0.27–1.02; P = 0.06), 1-year infection rate (OR 0.90; 95% CI 0.48–1.68; P = 0.73).

Conclusion

Induction therapy of basiliximab has similar short-time effects on the recipients in renal transplantation compared with that of ATG. However, regarding the long-term effect, as represented by the rate of neoplasm, basiliximab has a significant advantage.

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Authors and Affiliations

  1. Department of Surgical Urology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, Jiangsu, China

    Kun Wang & Min Fan

  2. Department of Surgical Urology, Sir Run Run Hospital, Nan Jing Medical University, Nanjing, 211100, Jiangsu, China

    Xianlin Xu

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  1. Kun Wang
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Correspondence to Xianlin Xu.

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The authors have declared that no conflict of interest exists.

Human and animal rights statement

This article does not contain any studies with human participants performed by any of the authors.

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Informed consent was obtained from all individual participants included in the study.

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Wang, K., Xu, X. & Fan, M. Induction therapy of basiliximab versus antithymocyte globulin in renal allograft: a systematic review and meta-analysis. Clin Exp Nephrol 22, 684–693 (2018). https://doi.org/10.1007/s10157-017-1480-z

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  • DOI: https://doi.org/10.1007/s10157-017-1480-z

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