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Prevalence of renal disease within an urban HIV-infected cohort in northern Italy

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Abstract

Background

Renal disease is an increasingly recognized noninfectious comorbidity associated with human immunodeficiency virus (HIV) infection.

Methods

Our retrospective, cross-sectional study evaluated prevalence of nephropathy among HIV-infected patients followed up in our outpatient clinic during the year 2011. Renal dysfunction and chronic kidney disease (CKD) were defined as estimated glomerular filtration rate (eGFR) <90 ml/min per 1.73 m2 and as renal damage or eGFR <60 ml/min per 1.73 m2 over a 3-month or greater period, respectively.

Results

We enrolled 894 HIV-infected patients with a mean age of 44.2 years and a mean current CD4 lymphocyte count of 508 cells/mm3. The prevalence of renal dysfunction and CKD was 27.4 and 21.3 %, respectively. Older age, male gender, hypertension, diabetes, proteinuria, hypertriglyceridemia, lower nadir CD4 cell count, current use of tenofovir or tenofovir plus a ritonavir-boosted protease inhibitor were independently associated with renal dysfunction.

Conclusion

Renal dysfunction is a frequent comorbidity among HIV-infected persons and requires a careful clinical and laboratory monitoring of renal function.

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Conflict of interest

The authors have declared that no conflict of interest exists.

Author information

Authors and Affiliations

  1. Section of Infectious Diseases, Department of Medical and Surgical Sciences, “Alma Mater Studiorum” University of Bologna, S.Orsola-Malpighi Hospital, via G. Massarenti 11, 40138, Bologna, Italy

    Leonardo Calza, Elisa Vanino, Eleonora Magistrelli, Caterina Salvadori, Alessandra Cascavilla, Vincenzo Colangeli, Maria Assunta Di Bari, Roberto Manfredi & Pierluigi Viale

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  1. Leonardo Calza
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  2. Elisa Vanino
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  3. Eleonora Magistrelli
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  4. Caterina Salvadori
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  5. Alessandra Cascavilla
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  6. Vincenzo Colangeli
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  7. Maria Assunta Di Bari
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  8. Roberto Manfredi
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  9. Pierluigi Viale
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Corresponding author

Correspondence to Leonardo Calza.

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Calza, L., Vanino, E., Magistrelli, E. et al. Prevalence of renal disease within an urban HIV-infected cohort in northern Italy. Clin Exp Nephrol 18, 104–112 (2014). https://doi.org/10.1007/s10157-013-0817-5

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  • DOI: https://doi.org/10.1007/s10157-013-0817-5

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