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A novel anchoring system for colonic stents: a pilot in vivo study in a porcine model

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Techniques in Coloproctology Aims and scope Submit manuscript

An Erratum to this article was published on 06 February 2014

Abstract

Background

Colorectal stents have a proven role in colorectal cancer as palliative care or a bridge to surgery. However, their efficacy and anchoring to the tissue varies according to stent design with stent migration rates up to 50 %. We present preliminary in vivo results of a new end-luminal anchoring system for stent fixation to the rectal canal. The aim was to assess the efficacy and safety of the stent using the anchoring system while subjecting the device to daily abdominal pressures related to daily activities in a porcine animal model.

Methods

Ex vivo anatomical and physical studies were performed to improve the system’s structure and safety. Four female pigs were followed for the acute and chronic (16 weeks) period. Two animals were euthanized and underwent en-bloc pelvic visceral excision and histopathological examination. Device fixation time, animal behavior, device patency, anoscopic examination and histopathological features were assessed.

Results

Mean anchoring time was 13.83 weeks (standard error ± 1.38 weeks). One of the animals experienced early device expulsion with no complications. No obstruction was noted in any of the animals. Macroscopic examination revealed mild focal submucosal scarring in one animal and a normal examination in the other. Hematoxylin and eosin staining revealed mucosal ulceration and mixed inflammatory cell infiltrate, with no signs of granulomata, foreign body giant cell reaction or microabscess formation.

Conclusions

A novel fixation device designed for long-term intrarectal implantation was well tolerated and maintained anal canal patency without migration. Larger studies are needed before its implementation in humans.

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Conflict of interest

The authors Dr. Avinoam Nevler and Dr. Yehiel Ziv are the founders and researchers of the Sphinx-Tech System.

Author information

Authors and Affiliations

  1. Department of Surgery and Transplantation, Chaim Sheba Medical Center, 52621, Tel-Hashomer, Israel

    A. Nevler

  2. Lahav Research Institute, Kibbutz Lahav, Israel

    U. Willantz & O. Doron

  3. Department of Pathology, Assaf Harofeh Medical Center, Zerifin, Israel

    J. Sandbank

  4. Coloproctology Unit, Division of Surgery, Assaf Harofeh Medical Center, 70300, Zerifin, Israel

    Y. Ziv

Authors
  1. A. Nevler
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  2. U. Willantz
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  3. O. Doron
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  4. J. Sandbank
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  5. Y. Ziv
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Corresponding author

Correspondence to Y. Ziv.

Additional information

Chaim Sheba Medical Center is affiliated with Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Assaf Harofeh Medical Center is affiliated with Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Dr. Avinoam Nevler and Dr. Yehiel Ziv have contributed equally to this work.

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Nevler, A., Willantz, U., Doron, O. et al. A novel anchoring system for colonic stents: a pilot in vivo study in a porcine model. Tech Coloproctol 18, 551–556 (2014). https://doi.org/10.1007/s10151-013-1097-5

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  • DOI: https://doi.org/10.1007/s10151-013-1097-5

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