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The impact of sex and age on distribution of metastases in patients with renal cell carcinoma

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Abstract

Background

Our objective was to investigate age and sex-related discrepancies on distribution of metastases in patients with metastatic renal cell carcinoma (RCC).

Methods

Within the National Inpatient Sample database (2008–2015) we identified 9607 patients with metastatic RCC. Trend test and Chi-square test analyses were used to evaluate the relationship between age and site of metastases, according to sex.

Results

Of 9607 patients with metastatic RCC, 6344 (65.9%) were men and 3263 (34.1%) were women. Thoracic, abdominal, bone and brain metastases were present in 51.1 vs. 52.8%, 42.6 vs. 44.3%, 29.9 vs. 29.2% and 8.6 vs. 8.8% of men vs. women, respectively. Increasing age was associated with decreasing rates of thoracic (from 55.5 to 48.5%) and brain (from 8.6 to 5.8%) metastases in men and with decreasing rates of abdominal (from 48.3 to 39.6%), bone (from 32.6 to 24.9%) and brain (from 8.8 to 5.4%) metastases in women. (all p < 0.05). Rates of concomitant metastatic sites also decreased with increasing age, from 57.1 to 50.8% in men and from 54.1 to 50.2% in women.

Conclusions

Important age and sex-related differences exist in the distribution of RCC metastases. The distribution of metastases is marginally different between sexes. Specifically, more advanced age is associated with lower rates of thoracic and brain metastases in men and with lower rates of abdominal, bone and brain metastases in women. Age and sex should be take into consideration into the staging management strategy, as well as into the follow-up strategy of patients with metastatic RCC.

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Acknowledgements

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Author information

Authors and Affiliations

  1. Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, QC, Canada

    Giuseppe Rosiello, Angela Pecoraro, Marina Deuker, Lara Franziska Stolzenbach, Thomas Martin, Zhe Tian, Fred Saad & Pierre I. Karakiewicz

  2. Department of Urology and Division of Experimental Oncology, URI, Urological Research Institute, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy

    Giuseppe Rosiello, Alessandro Larcher, Umberto Capitanio, Francesco Montorsi & Alberto Briganti

  3. Department of Urology, San Luigi Gonzaga Hospital, University of Turin, Turin, Italy

    Angela Pecoraro

  4. Department of Urology, University Hospital Frankfurt, Frankfurt am Main, Germany

    Marina Deuker

  5. Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany

    Lara Franziska Stolzenbach

  6. Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria

    Shahrokh F. Shariat

  7. Institute of Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Moscow, Russia

    Shahrokh F. Shariat

  8. Division of Urology, Department of Surgery, Juravinski Cancer Centre, McMaster University, Hamilton, ON, Canada

    Anil Kapoor

Authors
  1. Giuseppe Rosiello
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  2. Angela Pecoraro
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  3. Marina Deuker
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  4. Lara Franziska Stolzenbach
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  5. Thomas Martin
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  6. Zhe Tian
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  7. Alessandro Larcher
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  8. Umberto Capitanio
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  9. Francesco Montorsi
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  10. Shahrokh F. Shariat
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  11. Anil Kapoor
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  12. Fred Saad
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  13. Alberto Briganti
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  14. Pierre I. Karakiewicz
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Contributions

GR: project development, data collection, data analyses, manuscript writing. AP: data collection, manuscript editing; MD: data collection, manuscript editing; LFS: data collection, manuscript editing; TM: data collection, manuscript editing; ZT: data analyses; AL: manuscript editing; UC: manuscript editing; FM: manuscript editing; SFS: manuscript editing; AK: manuscript editing; FS: manuscript editing; AB: manuscript editing; PIK: Project development, manuscript writing.

Corresponding author

Correspondence to Giuseppe Rosiello.

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Rosiello, G., Pecoraro, A., Deuker, M. et al. The impact of sex and age on distribution of metastases in patients with renal cell carcinoma. Int J Clin Oncol 26, 962–970 (2021). https://doi.org/10.1007/s10147-021-01874-3

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  • DOI: https://doi.org/10.1007/s10147-021-01874-3

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