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Frequency and predictors of detecting early locoregional recurrence/disease progression of oral squamous cell carcinoma with high-risk factors on imaging tests before postoperative adjuvant radiotherapy

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Abstract

Background

To clarify the frequency and predictors of detecting early locoregional recurrence/disease progression (LR/DP) during the interval between surgery and postoperative adjuvant radiotherapy with/without chemotherapy in patients with oral squamous cell carcinoma.

Methods

Data on 65 patients who had undergone the initial radical surgery for previously untreated oral squamous cell carcinoma which were scheduled to receive adjuvant radiotherapy with/without chemotherapy were reviewed.

Results

Of the 65 patients, 63 (97%) were margin-positive/close and/or extracapsular extension-positive (hereinafter, high-risk factors). Eighteen (28%) patients had abnormal findings suggestive of LR/DP on postoperative imaging. Fifteen (23%) patients were diagnosed with LR/DP and treatment policy was changed. Univariate and multivariate analyses revealed higher frequencies of abnormal findings suggestive of LR/DP (univariate/multivariate analysis, p = 0.020/0.036), diagnosing of LR/DP, and changing the treatment policy (univariate/multivariate analysis, p = 0.042/0.046), among the patients who underwent postoperative diagnostic imaging tests or radiotherapy-planning contrast-enhanced (CE) CT without diagnostic imaging tests as compared with those who underwent radiotherapy-planning non-CECT without such tests.

Conclusion

The frequency of detecting of early LR/DP before postoperative adjuvant treatment in oral squamous cell carcinoma patients with high-risk factors was high. Furthermore, postoperative diagnostic imaging tests and radiotherapy-planning CECT may be useful to detect early LR/DP in oral squamous cell carcinoma patients before postoperative adjuvant therapy.

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Authors and Affiliations

  1. Department of Radiation Oncology and Particle Therapy, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan

    Yuichi Kibe, Naoki Nakamura, Sadamoto Zenda, Atsushi Motegi, Hidehiro Hojo, Masaki Nakamura, Takaki Ariji, Hajime Oyoshi & Tetsuo Akimoto

  2. Department of Diagnostic Radiology, National Cancer Center Hospital East, Kashiwa, Japan

    Hirofumi Kuno & Takashi Hiyama

  3. Department of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Japan

    Ryuichi Hayashi

Authors
  1. Yuichi Kibe
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  2. Naoki Nakamura
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  3. Hirofumi Kuno
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  4. Takashi Hiyama
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  5. Ryuichi Hayashi
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  7. Atsushi Motegi
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  9. Masaki Nakamura
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  12. Tetsuo Akimoto
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Corresponding author

Correspondence to Naoki Nakamura.

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Kibe, Y., Nakamura, N., Kuno, H. et al. Frequency and predictors of detecting early locoregional recurrence/disease progression of oral squamous cell carcinoma with high-risk factors on imaging tests before postoperative adjuvant radiotherapy. Int J Clin Oncol 24, 1182–1189 (2019). https://doi.org/10.1007/s10147-019-01479-x

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