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Prognostic factors and survival in Japanese patients with brain metastasis from renal cell cancer

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Abstract

Background

Patients with brain metastasis from renal cell carcinoma have poor outcomes despite recent advances in diagnosis and treatment. Moreover, factors affecting such poor outcomes are unclear. This study aimed to evaluate the prognostic factors associated with overall survival in renal cell carcinoma patients with brain metastasis.

Methods

We retrospectively reviewed the data of 50 consecutive patients with brain metastasis from renal cell carcinoma at our institution between 1988 and 2017. The evaluated prognostic factors for overall survival included clinicopathological factors at diagnosis, treatment for brain metastasis, and the Graded Prognostic Assessment score of renal cell carcinoma. The associations between preoperative clinicopathological factors and overall survival were assessed using the log-rank test and Cox proportional hazards models for univariate and multivariate analyses, respectively.

Results

Forty-five patients were included, among whom 39 died during follow-up. The median follow-up was 8.2 months. The median survival time was 8.2 months (95% confidence interval 5.5–13.7). A Graded Prognostic Assessment score ≤ 2 (hazard ratio 1.967; 95% confidence interval 1.024–3.892; P = 0.042), the presence of sarcomatoid components (hazard ratio 3.299; 95% confidence interval 1.424–7.193; P = 0.007), and no treatment for brain metastasis (hazard ratio 2.594; 95% confidence interval 1.033–5.858; P = 0.043) were independently associated with poor prognosis in the multivariate analysis.

Conclusions

Patients with renal cell carcinoma who develop brain metastasis have poor overall survival. The Graded Prognostic Assessment score, sarcomatoid components, and treatment for brain metastasis from renal cell carcinoma were independent factors associated with prognosis.

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Acknowledgements

The authors thank Editage for English language editing.

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Authors and Affiliations

  1. Prostate Center and Division of Urology, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8717, Japan

    Nobushige Takeshita, Masafumi Otsuka, Tomohiko Kamasako, Takatoshi Somoto, Toshihiro Uemura, Tetsuo Shinozaki, Masayuki Kobayashi, Atsushi Komaru & Satoshi Fukasawa

  2. Division of Surgical Pathology, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8717, Japan

    Hidetada Kawana & Makiko Itami

  3. Division of Neurological Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8717, Japan

    Toshihiko Iuchi

Authors
  1. Nobushige Takeshita
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  2. Masafumi Otsuka
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  3. Tomohiko Kamasako
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  4. Takatoshi Somoto
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  5. Toshihiro Uemura
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  6. Tetsuo Shinozaki
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  7. Masayuki Kobayashi
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  8. Hidetada Kawana
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  9. Makiko Itami
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  10. Toshihiko Iuchi
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  11. Atsushi Komaru
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  12. Satoshi Fukasawa
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Correspondence to Nobushige Takeshita.

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Takeshita, N., Otsuka, M., Kamasako, T. et al. Prognostic factors and survival in Japanese patients with brain metastasis from renal cell cancer. Int J Clin Oncol 24, 1231–1237 (2019). https://doi.org/10.1007/s10147-019-01474-2

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  • DOI: https://doi.org/10.1007/s10147-019-01474-2

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