International Journal of Clinical Oncology

, Volume 23, Issue 2, pp 266–274 | Cite as

A survival analysis using physique-adjusted tumor size of non-small cell lung cancer

  • Naoki OzekiEmail author
  • Takayuki Fukui
  • Koji Kawaguchi
  • Shota Nakamura
  • Shuhei Hakiri
  • Taketo Kato
  • Akihiro Hirakawa
  • Kohei Yokoi
Original Article



Differences in individual body sizes have not been well considered when analyzing the survival of patients with non-small cell lung cancer (NSCLC). We hypothesized that physique-adjusted tumor size is superior to actual tumor size in predicting the prognosis.


Eight hundred and forty-two patients who underwent R0 resection of NSCLC between 2005 and 2012 were retrospectively reviewed, and overall survival (OS) was evaluated. The physique-adjusted tumor size was defined as: x-adjusted tumor size = tumor size × mean value of x/individual value of x [x = height, weight, body surface area (BSA), or body mass index (BMI)]. Tumor size category was defined as ≤2, 2–3, 3–5, 5–7, and >7 cm. The separation index (SEP), which is the weighted mean of the absolute value of estimated regression coefficients over the subgroups with respect to a reference group, was used to measure the separation of subgroups.


The mean values of height, weight, BSA, and BMI were 160.7 cm, 57.6 kg, 1.59 m2, and 22.2 kg/m2, respectively. The 5-year survival rates ranged from 88−59% in the non-adjusted tumor size model (SEP 1.937), from 90−57% in the height-adjusted model (SEP 2.236), from 91−52% in the weight-adjusted model (SEP 2.146), from 90−56% in the BSA-adjusted model (SEP 2.077), and from 91−51% in the BMI-adjusted model (SEP 2.169).


The physique-adjusted tumor size can separate the survival better than the actual tumor size.


Lung cancer Body size Height Weight BMI Survival 


Compliance with ethical standards

Conflict of interest

The authors have declared that no conflict of interest exists.


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Copyright information

© Japan Society of Clinical Oncology 2017

Authors and Affiliations

  1. 1.Department of Thoracic SurgeryNagoya University Graduate School of MedicineNagoyaJapan
  2. 2.Statistical Analysis Section, Center for Advanced Medicine and Clinical ResearchNagoya University HospitalNagoyaJapan

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