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International Journal of Clinical Oncology

, Volume 23, Issue 2, pp 400–401 | Cite as

Further augmentation of molecular responses with dasatinib therapy in chronic myeloid leukemia patients who gained major molecular response under imatinib

  • Ahmet Emre Eskazan
Letter to the Editor
  • 115 Downloads

With the advent of imatinib—the first tyrosine kinase inhibitor (TKI) used to treat chronic myeloid leukemia (CML)—managing patients with CML in the chronic phase (CML-CP) has changed dramatically. Second-generation TKIs (2GTKIs) are more potent than imatinib and can be a better option. Nilotinib and dasatinib were superior to imatinib regarding speed and depth of responses, with no significant benefit in long-term outcomes, including progression-free and overall survivals (PFS and OS) over imatinib in the frontline setting [1].

Achieving and maintaining deep molecular response (DMR) may give patients an opportunity to temporarily discontinue TKI treatment, and treatment-free remission (TFR) was investigated in several studies, first with imatinib and then with 2GTKIs (nilotinib or dasatinib) [2]. Since the probability of gaining DMR is higher with 2GTKIs than with imatinib, it seems wiser to use these more potent TKIs in patients who wish to discontinue therapy.

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Notes

Compliance with ethical standards

Conflict of interest

AEE has received honoraria from Novartis and Bristol-Myers Squibb.

References

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Copyright information

© Japan Society of Clinical Oncology 2017

Authors and Affiliations

  1. 1.Division of Hematology, Department of Internal Medicine, Cerrahpasa Faculty of MedicineIstanbul UniversityIstanbulTurkey

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