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Histopathological and molecular predictors of growth patterns and recurrence in craniopharyngiomas: a systematic review

  • Josephine R. Coury
  • Brittany N. Davis
  • Christoforos P. Koumas
  • Giovanna S. Manzano
  • Amir R. Dehdashti
Review

Abstract

Craniopharyngiomas (CPs) are rare, benign tumors derived from Rathke’s pouch, known for their high recurrence rates and associated morbidity and mortality. Despite significant investigation on risk factors for recurrence, a lack of consensus persists. Recent research suggests that specific histopathological and molecular characteristics are prognostic for disease progression. In this systematic review, we analyzed and consolidated key features of CPs that contribute to increased recurrence rates. This systematic review was performed in accordance with PRISMA guidelines. A search string was created with the keywords “craniopharyngioma,” “histology,” “histopathology,” “molecular,” and “recurrence.” Literature was collected from 2006 to 2016 on the PubMed/Medline and Web of Science databases. The initial search resulted in 242 papers, examined with inclusion and exclusion criteria. The final review included a total of 37 studies, 36 primary studies covering a total of 1461 patients and 1 previous meta-analysis. Cystic lesions and whorl-like arrays were found to be associated with increased recurrence, while previously considered reactive gliosis and finger-shaped protrusions were not. The genetic elements found to be associated with increased risk of recurrence were Ki-67, Ep-CAM, PTTG-1, survivin, and certain RAR isotypes, as well as the glycoproteins osteonectin and chemokines CXCL12/CXCR4. The effects of VEGF, HIF-1α, and p53, despite extensive study, yielded conflicting results. Certain histopathological and molecular characteristics of CPs provide insight into their pathogenesis, likelihood of recurrence, and potential novel targets for therapy.

Keywords

Craniopharyngiomas Recurrence Histopathology Molecular Risk factors 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

None required, systematic review of literature. All studies included received ethical approval.

Informed consent

None required, systematic review of literature. All patients in the included previous studies provided informed consent.

References

  1. 1.
    Agozzino L, Ferraraccio F, Accardo M, Esposito S, Agozzino M, Cuccurullo L (2006) Morphological and ultrastructural findings of prognostic impact in craniopharyngiomas. Ultrastruct Pathol 30:143–150.  https://doi.org/10.1080/01913120500408018 CrossRefPubMedGoogle Scholar
  2. 2.
    Anegawa S, Hayashi T, Nakagawa S, Furukawa Y, Tomokiyo M (2001) Craniopharyngioma with rapid regrowth—role of MIB-1 labeling index. No Shinkei Geka 29:727–733PubMedGoogle Scholar
  3. 3.
    Bao Y, Peng JX (2016) Origin of craniopharyngiomas: implications for growth pattern, clinical characteristics, and outcomes of tumor recurrence. J Clin Neurosci 125:24–32.  https://doi.org/10.3171/2015.6.JNS141883 Google Scholar
  4. 4.
    Bao Y, Qiu BH, Qi ST, Pan J, Lu YT, Peng JX (2016) Influence of previous treatments on repeat surgery for recurrent craniopharyngiomas in children. Childs Nerv Syst 32:485–491.  https://doi.org/10.1007/s00381-015-3003-0 CrossRefPubMedGoogle Scholar
  5. 5.
    Bartlett JR (1971) Craniopharyngiomas. An analysis of some aspects of symptomatology, radiology and histology. Brain J Neurol 94:725–732.  https://doi.org/10.1093/brain/94.4.725 CrossRefGoogle Scholar
  6. 6.
    Botti G, Scognamiglio G, Marra L, Collina F, Di Bonito M, Cerrone M, Grilli B, Anniciello A, Franco R, Fulciniti F, Ascierto PA, Cantile M (2014) SPARC/osteonectin is involved in metastatic process to the lung during melanoma progression. Virchows Arch 465:331–338.  https://doi.org/10.1007/s00428-014-1616-4 CrossRefPubMedGoogle Scholar
  7. 7.
    Brastianos PK, Santagata S (2016) BRAF V600E mutations in papillary craniopharyngioma. Eur J Endocrinol 174:R139–R144CrossRefPubMedGoogle Scholar
  8. 8.
    Brastianos PK, Taylor-Weiner A, Manley PE, Jones RT, Dias-Santagata D, Thorner AR, Lawrence MS, Rodriguez FJ, Bernardo LA, Schubert L, Sunkavalli A, Shillingford N, Calicchio ML, Lidov HGW, Taha H, Martinez-Lage M, Santi M, Storm PB, Lee JYK, Palmer JN, Adappa ND, Scott RM, Dunn IF, Laws ER, Stewart C, Ligon KL, Hoang MP, Van Hummelen P, Hahn WC, Louis DN, Resnick AC, Kieran MW, Getz G, Santagata S (2014) Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. Nat Genet 46:161–U100.  https://doi.org/10.1038/ng.2868 CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Brastianos PK, Shankar GM, Gill CM, Taylor-Weiner A, Nayyar N, Panka DJ, Sullivan RJ, Frederick DT, Abedalthagafi M, Jones PS, Dunn IF, Nahed BV, Romero JM, Louis DN, Getz G, Cahill DP, Santagata S, Curry WT, Barker FG (2016) Dramatic response of BRAF V600E mutant papillary craniopharyngioma to targeted therapy. JNCI-J Natl Cancer Inst 108:5.  https://doi.org/10.1093/jnci/djv310 CrossRefGoogle Scholar
  10. 10.
    Burghaus S, Holsken A, Buchfelder M, Fahlbusch R, Riederer BM, Hans V, Blumcke I, Buslei R (2010) A tumor-specific cellular environment at the brain invasion border of adamantinomatous craniopharyngiomas. Virchows Arch 456:287–300.  https://doi.org/10.1007/s00428-009-0873-0 CrossRefPubMedGoogle Scholar
  11. 11.
    Buslei R, Nolde M, Hofmann B, Meissner S, Eyupoglu IY, Siebzehnrubl F, Hahnen E, Kreutzer J, Fahlbusch R (2005) Common mutations of beta-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region. Acta Neuropathol 109:589–597.  https://doi.org/10.1007/s00401-005-1004-x CrossRefPubMedGoogle Scholar
  12. 12.
    Cao J, Lin JP, Yang LX, Chen K, Huang ZS (2010) Expression of aberrant beta-catenin and impaired p63 in craniopharyngiomas. Br J Neurosurg 24:249–256.  https://doi.org/10.3109/02688690903576237 CrossRefPubMedGoogle Scholar
  13. 13.
    Cavallo LM, Frank G, Cappabianca P, Solari D, Mazzatenta D, Villa A, Zoli M, D'Enza AI, Esposito F, Pasquini E (2014) The endoscopic endonasal approach for the management of craniopharyngiomas: a series of 103 patients. J Neurosurg 121:100–113.  https://doi.org/10.3171/2014.3.jns131521 CrossRefPubMedGoogle Scholar
  14. 14.
    Cermak S, Kosicek M, Mladenovic-Djordjevic A, Smiljanic K, Kanazir S, Hecimovic S (2016) Loss of cathepsin B and L leads to lysosomal dysfunction, NPC-like cholesterol sequestration and accumulation of the key Alzheimer’s proteins. PLoS One 11:17.  https://doi.org/10.1371/journal.pone.0167428 CrossRefGoogle Scholar
  15. 15.
    Chuwa AH, Sone K, Oda K, Ikeda Y, Fukuda T, Wada-Hiraike O, Inaba K, Makii C, Takeuchi M, Oki S, Miyasaka A, Kashiyama T, Arimoto T, Kuramoto H, Kawana K, Yano T, Osuga Y, Fujii T (2016) Significance of survivin as a prognostic factor and a therapeutic target in endometrial cancer. Gynecol Oncol 141:564–569.  https://doi.org/10.1016/j.ygyno.2016.04.003 CrossRefPubMedGoogle Scholar
  16. 16.
    Crotty TB, Scheithauer BW, Young WF, Davis DH, Shaw EG, Miller GM, Burger PC (1995) Papillary craniopharyngioma—a clinicopathological study of 48 cases. J Neurosurg 83:206–214.  https://doi.org/10.3171/jns.1995.83.2.0206 CrossRefPubMedGoogle Scholar
  17. 17.
    Cseh B, Doma E, Baccarini M (2014) “RAF” neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway. FEBS Lett 588:2398–2406.  https://doi.org/10.1016/j.febslet.2014.06.025 CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    Dehdashti AR, Ganna A, Witterick I, Gentili F (2009) Expanded endoscopic endonasal approach for anterior cranial base and suprasellar lesions: indications and limitations. Neurosurgery 64:677–687; discussion 687-679.  https://doi.org/10.1227/01.neu.0000339121.20101.85 CrossRefPubMedGoogle Scholar
  19. 19.
    Drimtzias E, Falzon K, Picton S, Jeeva I, Guy D, Nelson O, Simmons I (2014) The ophthalmic natural history of paediatric craniopharyngioma: a long-term review. J Neuro-Oncol 120:651–656.  https://doi.org/10.1007/s11060-014-1600-5 CrossRefGoogle Scholar
  20. 20.
    Duff JM, Meyer FB, Ilstrup DM, Laws ER, Schleck CD, Scheithauer BW (2000) Long-term outcomes for surgically resected craniopharyngiomas. Neurosurgery 46:291–302.  https://doi.org/10.1097/00006123-200002000-00007 CrossRefPubMedGoogle Scholar
  21. 21.
    Duo D, Gasverde S, Benech F, Zenga F, Giordana MT (2003) MIB-1 immunoreactivity in craniopharyngiomas: a clinico-pathological analysis. Clin Neuropathol 22:229–234PubMedGoogle Scholar
  22. 22.
    Ebrahimi A, Honegger J, Schluesener H, Schittenhelm J (2013) Osteonectin expression in surrounding stroma of craniopharyngiomas: association with recurrence rate and brain infiltration. Int J Surg Pathol 21:591–598.  https://doi.org/10.1177/1066896913486695 CrossRefPubMedGoogle Scholar
  23. 23.
    Garnett MR, Puget S, Grill J, Sainte-Rose C (2007) Craniopharyngioma. Orphanet J Rare Dis 2:18.  https://doi.org/10.1186/1750-1172-2-18 CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    Gong J, Zhang HL, Xing SS, Li CD, Ma ZY, Jia G, Hu WN (2014) High expression levels of CXCL12 and CXCR4 predict recurrence of adamantinomatous craniopharyngiomas in children. Cancer Biomark 14:241–251.  https://doi.org/10.3233/cbm-140397 CrossRefPubMedGoogle Scholar
  25. 25.
    Gupta DK, Ojha BK, Sarkar C, Mahapatra AK, Mehta VS (2006) Recurrence in craniopharyngiomas: analysis of clinical and histological features. J Clin Neurosci 13:438–442.  https://doi.org/10.1016/j.jocn.2005.05.013 CrossRefPubMedGoogle Scholar
  26. 26.
    Gupta DK, Ojha BK, Sarkar C, Mahapatra AK, Sharma BS, Mehta VS (2006) Recurrence in pediatric craniopharyngiomas: analysis of clinical and histological features. Childs Nerv Syst 22:50–55.  https://doi.org/10.1007/s00381-005-1171-z CrossRefPubMedGoogle Scholar
  27. 27.
    Holsken A, Stache C, Schlaffer SM, Flitsch J, Fahlbusch R, Buchfelder M, Buslei R (2014) Adamantinomatous craniopharyngiomas express tumor stem cell markers in cells with activated Wnt signaling: further evidence for the existence of a tumor stem cell niche? Pituitary 17:546–556.  https://doi.org/10.1007/s11102-013-0543-8 CrossRefPubMedGoogle Scholar
  28. 28.
    Hussain I, Eloy JA, Carmel PW, Liu JK (2013) Molecular oncogenesis of craniopharyngioma: current and future strategies for the development of targeted therapies A review. J Neurosurg 119:106–112.  https://doi.org/10.3171/2013.3.jns122214 CrossRefPubMedGoogle Scholar
  29. 29.
    Ishida M, Hotta M, Tsukamura A, Taga T, Kato H, Ohta S, Takeuchi Y, Nakasu S, Okabe H (2010) Malignant transformation in craniopharyngioma after radiation therapy: a case report and review of the literature. Clin Neuropathol 29:2–8CrossRefPubMedGoogle Scholar
  30. 30.
    Izumoto S, Suzuki T, Kinoshita M, Hashiba T, Kagawa N, Wada K, Fujimoto Y, Hashimoto N, Saitoh Y, Maruno M, Yoshimine T (2005) Immunohistochemical detection of female sex hormone receptors in craniopharyngiomas: correlation with clinical and histologic features. Surg Neurol 63:520–525.  https://doi.org/10.1016/j.surneu.2004.08.094 CrossRefPubMedGoogle Scholar
  31. 31.
    Kapinas K, Lowther KM, Kessler CB, Tilbury K, Lieberman JR, Tirnauer JS, Campagnola P, Delany AM (2012) Bone matrix osteonectin limits prostate cancer cell growth and survival. Matrix Biol 31:299–307.  https://doi.org/10.1016/j.matbio.2012.03.002 CrossRefPubMedPubMedCentralGoogle Scholar
  32. 32.
    Kato K, Nakatani Y, Kanno H, Inayama Y, Ijiri R, Nagahara N, Miyake T, Tanaka M, Ito Y, Aida N, Tachibana K, Sekido K, Tanaka Y (2004) Possible linkage between specific histological structures and aberrant reactivation of the Wnt pathway in adamantinomatous craniopharyngioma. J Pathol 203:814–821.  https://doi.org/10.1002/path.1562 CrossRefPubMedGoogle Scholar
  33. 33.
    Katz EL (1975) Late results of radical excision of craniopharyngiomas in children. J Neurosurg 42:86–93.  https://doi.org/10.3171/jns.1975.42.1.0086 CrossRefPubMedGoogle Scholar
  34. 34.
    Kim S, An SS (2016) Role of p53 isoforms and aggregations in cancer. Medicine 95:e3993.  https://doi.org/10.1097/md.0000000000003993 CrossRefPubMedPubMedCentralGoogle Scholar
  35. 35.
    Kim SK, Wang KC, Shin SH, Choe G, Chi JG, Cho BK (2001) Radical excision of pediatric craniopharyngioma: recurrence pattern and prognostic factors. Childs Nerv Syst 17:531–536.  https://doi.org/10.1007/s003810100458 CrossRefPubMedGoogle Scholar
  36. 36.
    Kobayashi T, Tsugawa T, Hatano M, Hashizume C, Mori Y, Shibamoto Y (2015) Gamma knife radiosurgery of craniopharyngioma: results of 30 cases treated at Nagoya Radiosurgery Center. Nagoya J Med Sci 77:447–454PubMedPubMedCentralGoogle Scholar
  37. 37.
    Koutourousiou M, Gardner PA, Fernandez-Miranda JC, Tyler-Kabara EC, Wang EW, Snyderman CH (2013) Endoscopic endonasal surgery for craniopharyngiomas: surgical outcome in 64 patients Clinical article. J Neurosurg 119:1194–1207.  https://doi.org/10.3171/2013.6.jns122259 CrossRefPubMedGoogle Scholar
  38. 38.
    Larkin SJ, Ansorge O (2013) Pathology and pathogenesis of craniopharyngiomas. Pituitary 16:9–17.  https://doi.org/10.1007/s11102-012-0418-4 CrossRefPubMedGoogle Scholar
  39. 39.
    Lee EJ, Cho YH, Hong SH, Kim JH, Kim CJ (2015) Is the complete resection of craniopharyngiomas in adults feasible considering both the oncologic and functional outcomes? J Korean Neurosurg Soc 58:432–441.  https://doi.org/10.3340/jkns.2015.58.5.432 CrossRefPubMedPubMedCentralGoogle Scholar
  40. 40.
    Lefranc F, Chevalier C, Vinchon M, Dhellemmes P, Schuring MP, Kaltner H, Brotchi J, Ruchoux MM, Gabius HJ, Salmon I, Kiss R (2003) Characterization of the levels of expression of retinoic acid receptors, galectin-3, macrophage migration inhibiting factor, and p53 in 51 adamantinomatous craniopharyngiomas. J Neurosurg 98:145–153.  https://doi.org/10.3171/jns.2003.98.1.0145 CrossRefPubMedGoogle Scholar
  41. 41.
    Lefranc F, Mijatovic T, Decaestecker C, Kaltner H, Andre S, Brotchi J, Salmon I, Gabius HJ, Kiss R (2005) Monitoring the expression profiles of integrins and adhesion/growth-regulatory galectins in adamantinomatous craniopharyngiomas: their ability to regulate tumor adhesiveness to surrounding tissue and their contribution to prognosis. Neurosurgery 56:763–776CrossRefPubMedGoogle Scholar
  42. 42.
    Liu H, Liu ZY, Li J, Li Q, You C, Xu JG (2014) Relative quantitative expression of hypoxia-inducible factor 1 alpha messenger ribonucleic acid in recurrent craniopharyngiomas. Neurol India 62:53–56.  https://doi.org/10.4103/0028-3886.128291 CrossRefPubMedGoogle Scholar
  43. 43.
    Liubinas SV, Munshey AS, Kaye AH (2011) Management of recurrent craniopharyngioma. J Clin Neurosci 18:451–457.  https://doi.org/10.1016/j.jocn.2010.10.004 CrossRefPubMedGoogle Scholar
  44. 44.
    Losa M, Vimercati A, Acerno S, Barzaghi RL, Mortini P, Mangili F, Terreni MR, Santambrogio G, Giovanelli M (2004) Correlation between clinical characteristics and proliferative activity in patients with craniopharyngioma. J Neurol Neurosurg Psychiatry 75:889–892CrossRefPubMedPubMedCentralGoogle Scholar
  45. 45.
    Lubansu A, Ruchoux MM, Brotchi J, Salmon I, Kiss R, Lefranc F (2003) Cathepsin B, D and K expression in adamantinomatous craniopharyngiomas relates to their levels of differentiation as determined by the patterns of retinoic acid receptor expression. Histopathology 43:563–572.  https://doi.org/10.1111/j.1365-2559.2003.01751.x CrossRefPubMedGoogle Scholar
  46. 46.
    Metzger J, Nachanakian A, Gardeur D, Sichez JP (1979) CT follow-up studies in postoperative craniopharyngiomas. Acta Neurochir Suppl 28:357–361PubMedGoogle Scholar
  47. 47.
    Minamida Y, Mikami T, Hashi K, Houkin K (2005) Surgical management of the recurrence and regrowth of craniopharyngiomas. J Neurosurg 103:224–232.  https://doi.org/10.3171/jns.2005.103.2.0224 CrossRefPubMedGoogle Scholar
  48. 48.
    Mirza A, McGuirk M, Hockenberry TN, Wu Q, Ashar H, Black S, Wen SF, Wang LQ, Kirschmeier P, Bishop WR, Nielsen LL, Pickett CB, Liu SX (2002) Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway. Oncogene 21:2613–2622.  https://doi.org/10.1038/sj/onc/1205353 CrossRefPubMedGoogle Scholar
  49. 49.
    Momota H, Ichimiya S, Ikeda T, Yamaki T, Kikuchi T, Houkin K, Sato N (2003) Immunohistochemical analysis of the p53 family members in human craniopharyngiomas. Brain Tumor Pathol 20:73–77.  https://doi.org/10.1007/bf02483450 CrossRefPubMedGoogle Scholar
  50. 50.
    Mortini P, Gagliardi F, Boari N, Losa M (2013) Surgical strategies and modern therapeutic options in the treatment of craniopharyngiomas. Crit Rev Oncol/Hematol 88:514–529.  https://doi.org/10.1016/j.critrevonc.2013.07.013 CrossRefGoogle Scholar
  51. 51.
    Muller HL (2014) Craniopharyngioma. Endocr Rev 35:513–543.  https://doi.org/10.1210/er.2013-1115 CrossRefPubMedGoogle Scholar
  52. 52.
    Munz M, Kieu C, Mack B, Schmitt B, Zeidler R, Gires O (2004) The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation. Oncogene 23:5748–5758.  https://doi.org/10.1038/sj.onc.1207610 CrossRefPubMedGoogle Scholar
  53. 53.
    Nishi T, Kuratsu J, Takeshima H, Saito Y, Kochi M, Ushio Y (1999) Prognostic significance of the MIB-1 labeling index for patient with craniopharyngioma. Int J Mol Med 3:157–161PubMedGoogle Scholar
  54. 54.
    Papatheodorou H, Papanastasiou AD, Sirinian C, Scopa C, Kalofonos HP, Leotsinidis M, Papadaki H (2014) Expression patterns of SDF1/CXCR4 in human invasive breast carcinoma and adjacent normal stroma: correlation with tumor clinicopathological parameters and patient survival. Pathol Res Pract 210:662–667.  https://doi.org/10.1016/j.prp.2014.06.015 CrossRefPubMedGoogle Scholar
  55. 55.
    Pekmezci M, Louie J, Gupta N, Bloomer MM, Tihan T (2010) Clinicopathological characteristics of adamantinomatous and papillary craniopharyngiomas: University of California, San Francisco experience 1985–2005. Neurosurgery 67:1341–1349.  https://doi.org/10.1227/NEU.0b013e3181f2b583 CrossRefPubMedGoogle Scholar
  56. 56.
    Prieto R, Pascual JM, Subhi-Issa I, Jorquera M, Yus M, Martinez R (2013) Predictive factors for craniopharyngioma recurrence: a systematic review and illustrative case report of a rapid recurrence. World Neurosurg 79:733–749.  https://doi.org/10.1016/j.wneu.2012.07.033 CrossRefPubMedGoogle Scholar
  57. 57.
    Qi ST, Lu YT, Pan J, Zhang XA, Long H, Fan J (2011) Anatomic relations of the arachnoidea around the pituitary stalk: relevance for surgical removal of craniopharyngiomas. Acta Neurochir 153:785–796.  https://doi.org/10.1007/s00701-010-0940-y CrossRefPubMedPubMedCentralGoogle Scholar
  58. 58.
    Raghavan R, Dickey WT Jr, Margraf LR, White Iii CL, Coimbra C, Hynan LS, Rushing EJ (2000) Proliferative activity in craniopharyngiomas: clinicopathological correlations in adults and children. Surg Neurol 54:241–248.  https://doi.org/10.1016/S0090-3019(00)00298-6 CrossRefPubMedGoogle Scholar
  59. 59.
    Rodriguez FJ, Scheithauer BW, Tsunoda S, Kovacs K, Vidal S, Piepgras DG (2007) The spectrum of malignancy in craniopharyngioma. Am J Surg Pathol 31:1020–1028.  https://doi.org/10.1097/PAS.0b013e31802d8a96 CrossRefPubMedGoogle Scholar
  60. 60.
    Scholzen T, Gerdes J (2000) The Ki-67 protein: from the known and the unknown. J Cell Physiol 182:311–322.  https://doi.org/10.1002/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9 CrossRefPubMedGoogle Scholar
  61. 61.
    Schweizer L, Capper D, Holsken A, Fahlbusch R, Flitsch J, Buchfelder M, Herold-Mende C, von Deimling A, Buslei R (2015) BRAF V600E analysis for the differentiation of papillary craniopharyngiomas and Rathke’s cleft cysts. Neuropathol Appl Neurobiol 41:733–742.  https://doi.org/10.1111/nan.12201 CrossRefPubMedGoogle Scholar
  62. 62.
    Sekine S, Shibata T, Kokubu A, Morishita Y, Noguchi M, Nakanishi Y, Sakamoto M, Hirohashi S (2002) Craniopharyngiomas of adamantinomatous type harbor beta-catenin gene mutations. Am J Pathol 161:1997–2001CrossRefPubMedPubMedCentralGoogle Scholar
  63. 63.
    Stache C, Holsken A, Schlaffer SM, Hess A, Metzler M, Frey B, Fahlbusch R, Flitsch J, Buchfelder M, Buslei R (2015) Insights into the infiltrative behavior of adamantinomatous craniopharyngioma in a new xenotransplant mouse model. Brain Pathol 25:1–10.  https://doi.org/10.1111/bpa.12148 CrossRefPubMedGoogle Scholar
  64. 64.
    Steno J, Bizik I, Steno A, Matejcik V (2014) Recurrent craniopharyngiomas in children and adults: long-term recurrence rate and management. Acta Neurochir 156:113–122.  https://doi.org/10.1007/s00701-013-1938-z CrossRefPubMedGoogle Scholar
  65. 65.
    Sun J, Nemoto E, Hong G, Sasaki K (2016) Modulation of stromal cell-derived factor 1 alpha (SDF-1alpha) and its receptor CXCR4 in Porphyromonas gingivalis-induced periodontal inflammation. BMC Oral Health 17:26.  https://doi.org/10.1186/s12903-016-0250-8 CrossRefPubMedPubMedCentralGoogle Scholar
  66. 66.
    Szeifert GT, Sipos L, Horvath M, Sarker MH, Major O, Salomvary B, Czirjak S, Balint K, Slowik F, Kolonics L, Pasztor E (1993) Pathological characteristics of surgically removed craniopharyngiomas—analysis of 131 cases. Acta Neurochir 124:139–143.  https://doi.org/10.1007/bf01401137 CrossRefPubMedGoogle Scholar
  67. 67.
    Tavangar SM, Larijani B, Mahta A, Hosseini SM, Mehrazine M, Bandarian F (2004) Craniopharyngioma: a clinicopathological study of 141 cases. Endocr Pathol 15:339–344CrossRefPubMedGoogle Scholar
  68. 68.
    Tena-Suck ML, Salinas-Lara C, Arce-Arellano RI, Rembao-Bojorquez D, Morales-Espinosa D, Sotelo J, Arrieta O (2006) Clinico-pathological and immunohistochemical characteristics associated to recurrence/regrowth of craniopharyngiomas. Clin Neurol Neurosurg 108:661–669.  https://doi.org/10.1016/j.clineuro.2006.01.007 CrossRefPubMedGoogle Scholar
  69. 69.
    Tena-Suck ML, Ortiz-Plata A, Galan F, Sanchez A (2009) Expression of epithelial cell adhesion molecule and pituitary tumor transforming gene in adamantinomatous craniopharyngioma and its correlation with recurrence of the tumor. Ann Diagn Pathol 13:82–88.  https://doi.org/10.1016/j.anndiagpath.2008.12.004 CrossRefPubMedGoogle Scholar
  70. 70.
    Thimsen V, Holsken A, Buchfelder M, Flitsch J, Fahlbusch R, Stefanits H, Losa M, Jones DTW, Buslei R (2016) EpCAM (CD326) is differentially expressed in craniopharyngioma subtypes and Rathke’s cleft cysts. Sci Rep 6:10.  https://doi.org/10.1038/srep29731 CrossRefGoogle Scholar
  71. 71.
    Ujifuku K, Matsuo T, Takeshita T, Hayashi Y, Hayashi K, Kitagawa N, Hayashi T, Suyama K, Nagata I (2010) Malignant transformation of craniopharyngioma associated with moyamoya syndrome—case report. Neurol Med-Chir 50:599–603CrossRefGoogle Scholar
  72. 72.
    Weiner HL, Wisoff JH, Rosenberg ME, Kupersmith MJ, Cohen H, Zagzag D, Shiminskimaher T, Flamm ES, Epstein FJ, Miller DC (1994) Craniopharyngiomas—a clinicopathological analysis of factors predictive of recurrence and functional. Neurosurgery 35:1001–1010CrossRefPubMedGoogle Scholar
  73. 73.
    Went P, Vasei M, Bubendorf L, Terracciano L, Tornillo L, Riede U, Kononen J, Simon R, Sauter G, Baeuerle PA (2006) Frequent high-level expression of the immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung cancers. Br J Cancer 94:128–135.  https://doi.org/10.1038/sj.bjc.6602924 CrossRefPubMedPubMedCentralGoogle Scholar
  74. 74.
    Xu JG, Zhang SH, You C, Wang XJ, Zhou Q (2006) Microvascular density and vascular endothelial growth factor have little correlation with prognosis of craniopharyngioma. Surg Neurol 66:30–34.  https://doi.org/10.1016/j.surneu.2006.05.047 CrossRefGoogle Scholar
  75. 75.
    Yalcin N, Akbulut M, Cagli S, Bir F, Demirtas E (2009) Prognostic significance of the Ki-67 labeling index and P53 protein expression for patient with craniopharyngioma. J Neurol Sci-Turk 26:286–291Google Scholar
  76. 76.
    Yosef L, Ekkehard KM, Shalom M (2016) Giant craniopharyngiomas in children: short- and long-term implications. Childs Nerv Syst 32:79–88.  https://doi.org/10.1007/s00381-015-2961-6 CrossRefPubMedGoogle Scholar
  77. 77.
    Yu R, Melmed S (2001) Oncogene activation in pituitary tumors. Brain Pathol 11:328–341CrossRefPubMedGoogle Scholar
  78. 78.
    Zhu J, You C (2015) Craniopharyngioma: survivin expression and ultrastructure. Oncol Lett 9:75–80.  https://doi.org/10.3892/ol.2014.2690 CrossRefPubMedGoogle Scholar
  79. 79.
    Zygourakis CC, Kaur G, Kunwar S, McDermott MW, Madden M, Oh T, Parsa AT (2014) Modern treatment of 84 newly diagnosed craniopharyngiomas. J Clin Neurosci 21:1558–1566.  https://doi.org/10.1016/j.jocn.2014.03.005 CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Josephine R. Coury
    • 1
  • Brittany N. Davis
    • 1
    • 2
  • Christoforos P. Koumas
    • 1
  • Giovanna S. Manzano
    • 1
    • 3
  • Amir R. Dehdashti
    • 4
  1. 1.Hofstra Northwell School of MedicineManhassetUSA
  2. 2.Department of General SurgeryStamford Hospital/Columbia UniversityStamfordUSA
  3. 3.Department of NeurologyMassachusetts General Hospital/Brigham & Women’s HospitalBostonUSA
  4. 4.Department of NeurosurgeryNorthshore University HospitalManhassetUSA

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