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Meningiomas: skull base versus non-skull base

  • Torstein R. Meling
  • Michele Da Broi
  • David Scheie
  • Eirik Helseth
Original Article

Abstract

To identify differences between skull base meningiomas (SBM) and non-skull base meningiomas (NSBM). All adult patients (18.0–69.9 years) operated for intracranial meningiomas between 1990 and 2010 at our institution were investigated. Al-Mefty’s definition was used to dichotomize tumors into SBM and NSBM. Overall, 1148 consecutive patients were identified. Median age at surgery was 54.2 years [18.1–69.9]. Median follow-up was 7.4 years [0.0–20.9]. There were 562 patients (49%) with SBM and 586 (51%) with NSBM. The two groups were similar with respect to patient age, follow-up time, and number of patients. Overall female-to-male ratio was 2.6:1, but 3.2:1 in SBM and 2.2:1 in NSBM (p < 0.005). With respect to presenting symptoms, SBMs had more often neurological deficits (risk ratio (RR) 1.4; p < 0.0001) and less often seizures (RR 0.4; p < 0.0001). Gross total resections were less frequent in SBM than NSBM (62 vs 84%) (RR 1.3; p < 0.0001). SBMs had a lower risk of WHO grades II and III histology (4.5 vs 9.5%) (RR 0.5; p < 0.001). Worsening of neurological function was more frequent in SBM (21 vs 121%) (RR 1.8; p < 0.001). Retreatment-free survival at 5, 10, and 15 years, respectively, was 80, 70, and 62% for SBM versus 90, 82, and 74% for NSBM (p < 0.0001). Overall survival at 5, 10, and 15 years, respectively, was 93, 85, and 78% for SBM and 96, 91, and 79% for NSBM (p = 0.14). Patients with SBMs had more new-onset neurological deficits and significantly shorter retreatment-free survivals, but this did not adversely affect the overall survival.

Keywords

Craniotomy Intracranial tumor Meningioma Retreatment-free survival Overall survival 

Notes

Acknowledgements

The authors would like to thank Bernt Filip Hasseleid, MD; Andreas Mathisen, MD; Andreas Hessen Schei, MD; and Kristina M Ødegaard, MD, for their valuable contributions in collecting data for this manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

For this type of study, formal consent is not required.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Torstein R. Meling
    • 1
    • 2
  • Michele Da Broi
    • 1
  • David Scheie
    • 3
  • Eirik Helseth
    • 1
    • 2
  1. 1.Faculty of MedicineUniversity of OsloOsloNorway
  2. 2.Department of NeurosurgeryOslo University HospitalOsloNorway
  3. 3.Department of Pathology, Section of NeuropathologyRigshospitaletCopenhagenDenmark

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