International cost-effectiveness analysis evaluating endoscopic screening for gastric cancer for populations with low and high risk

Abstract

Background

Gastric cancer remains one of the 3 most common causes of cancer death worldwide. Understanding the health and economic factors that affect screening cost-effectiveness in different countries will help address when and where it makes most sense to screen for gastric cancer.

Methods

We performed a cost-effectiveness analysis using a Markov model to compare screening and surveillance strategies for gastric cancer in Brazil, France, Japan, Nigeria, and the United States. Primary outcome was the incremental cost-effectiveness ratio. We then performed a sensitivity analysis to determine how each variable affected the overall model.

Results

In all countries, the most cost-effective strategies, measured by incremental cost-effectiveness ratio relative to no screening, were screening every 10 years, surveillance of high- and low-risk patients every 5 and 10 years, respectively, and screening every 5 years. Only Japan had at least one cost-effective screening strategy. The most important variables across different screening strategies and countries were starting age of screening, cost of endoscopy, and baseline probability of local gastric cancer at time of diagnosis.

Conclusions

Our model suggests that screening for gastric cancer is cost-effective in countries with higher incidence and lower costs of screening, but screening may still be a viable option in high-risk populations within low incidence countries.

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Source: National Cancer Institute (NCI) Cancer Atlas [33]

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Acknowledgements

None.

Funding

Institutional. No external funding.

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Authors

Contributions

Study concept and design: BA, AO, and CH. Acquisition of data: BA, AO, and CH. Analysis and interpretation of data: BA, AO, and CH. Drafting of the manuscript: BA, AO, and CH. Administrative, technical, or material support: CH. Study supervision: CH.

Corresponding author

Correspondence to Benjamin Ascherman.

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Cite this article

Ascherman, B., Oh, A. & Hur, C. International cost-effectiveness analysis evaluating endoscopic screening for gastric cancer for populations with low and high risk. Gastric Cancer (2021). https://doi.org/10.1007/s10120-021-01162-z

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Keywords

  • Gastric cancer (GC)
  • Endoscopy
  • Screening
  • Cost-effectiveness
  • Quality adjusted life year (QALY)