Gastric Cancer

, Volume 20, Issue 6, pp 978–986 | Cite as

Endoscopic submucosal dissection for papillary adenocarcinoma of the stomach: is it really safe?

  • Hyun Jung Lee
  • Gwang Ha Kim
  • Do Youn Park
  • Young Keum Kim
  • Hye Kyung Jeon
  • Bong Eun Lee
  • Geun Am Song
Original Article



Papillary adenocarcinoma of the stomach has been treated according to the same endoscopic submucosal dissection (ESD) indication criteria as other differentiated-type adenocarcinomas. We aimed to compare lymph node metastasis (LNM) in patients with early gastric cancer (EGC) with papillary adenocarcinoma (EGC-P) with that in patients with EGC with nonpapillary adenocarcinoma (EGC-NP) and to consider the potential limitation of current ESD indication criteria in the treatment of EGC-P.


In total, 1583 patients who underwent gastrectomy for EGC from 2005 to 2014 were included. Clinicopathologic characteristics of 56 patients with EGC-P were compared with those of 1527 patients with EGC-NP. The safety of ESD was evaluated, by application of current ESD indication criteria to EGC-P.


The frequency of submucosal invasion was significantly higher in EGC-P than in both EGC-NP with differentiated-type histologic appearance and EGC-NP with undifferentiated-type histologic appearance (71.4% vs 50.8% and 37.6%, respectively). In addition, the frequency of LNM in EGC-P was 17.9%, higher than that in both EGC-NP with differentiated-type histologic appearance and EGC-NP with undifferentiated-type histologic appearance (9.7% and 11.1%, respectively). When the current ESD indication criteria were applied to the 56 patients with EGC-P, 17 patients met the current indications. Of these patients, two (11.8%) had LNM and three (17.6%) had lymphovascular invasion (LVI). When LNM and LVI were combined, one of seven patients (16.7%) meeting the absolute ESD indications and three of ten patients (30.0%) meeting the expanded ESD indications would not be cured after ESD.


The use of ESD should be more carefully applied in patients with EGC-P meeting the ESD indication criteria, especially the expanded indication criteria, after pretreatment workup compared with other differentiated-type adenocarcinomas, owing to the higher frequencies of submucosal invasion, LNM, and LVI in EGC-P.


Early gastric cancer Papillary adenocarcinoma Endoscopic submucosal dissection Lymph node Metastasis 



This study was supported by a grant from the National R&D Program for Cancer Control, Ministry for Health, Welfare and Family Affairs, Republic of Korea (0920050), and by the Medical Research Center Program through a National Research Foundation of Korea grant funded by the Korean government (NRF-2015R1A5A2009656).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Human rights statement and informed consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Declaration of Helsinki of 1964 and later versions. Informed consent or a substitute for it was obtained from all patients for their being included in the study.

Supplementary material

10120_2017_709_MOESM1_ESM.docx (20 kb)
Supplementary material 1 (DOCX 20 kb)


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Copyright information

© The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2017

Authors and Affiliations

  • Hyun Jung Lee
    • 1
  • Gwang Ha Kim
    • 1
  • Do Youn Park
    • 2
  • Young Keum Kim
    • 2
  • Hye Kyung Jeon
    • 1
  • Bong Eun Lee
    • 1
  • Geun Am Song
    • 1
  1. 1.Department of Internal Medicine, Pusan National University School of Medicine, and Biomedical Research InstitutePusan National University HospitalBusanSouth Korea
  2. 2.Department of Pathology, Pusan National University School of Medicine, and Biomedical Research InstitutePusan National University HospitalBusanSouth Korea

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