Effects of laser therapy on periorbital hyperpigmentation: a systematic review on current studies


Periorbital hyperpigmentation is a problem with complex multifactorial etiology, with early knowledge expanding. The purpose of the present study was to review studies on the efficacy of laser on periorbital hyperpigmentation. A systematic review of the data banks of scientific and research articles including PubMed, Web of Knowledge, Google Scholar, SCOPUS, and Iranian databases including SID and Magiran is performed. The following keywords were used to evaluate existing articles: Periorbital Hyperpigmentation, Periorbital Darkening, Dark Eye Circle, Eye Dark Circle, Infraorbital Hyperpigmentation, Infraorbital Dark Circle, and Laser (1990–2018). Finally, 10 clinical trial articles were included. A total of 2.76% of patients responded poor, 11.4% responded fair to different types of lasers, 45.3% responded good, and 35.9% excellent responded to have been cured. As a long-term effect, less than 1% of patients received a poor score after their laser treatment. Twenty-five percent of the patients showed a fair result. In total, 26.27% of patients achieved good and 43.35% of patients received excellent response from laser treatment on periorbital hyperpigmentation after 4–6 months of laser therapy. A large percentage of patients (76.4%) were satisfied with the effect of lasers on the reduction of moderate to high periorbital hyperpigmentation rates in the studies. Laser therapy is an effective and satisfactory therapeutic choice for treatment of periorbital hyperpigmentation. Also, it is safe overall with favorable sustainable results, although the follow-up periods usually last about several months.

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The authors would like to thank the Rasool Akram Medical Complex Clinical Research Development Center (RCRDC) for its technical and editorial assistance.


This study was financially supported by the vice chancellor of Iran University of Medical Sciences.

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Correspondence to Azadeh Goodarzi.

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The ethical code of this study was IR.IUMS.FMD.REC 1396.9011216159.

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Roohaninasab, M., Sadeghzadeh-Bazargan, A. & Goodarzi, A. Effects of laser therapy on periorbital hyperpigmentation: a systematic review on current studies. Lasers Med Sci (2021). https://doi.org/10.1007/s10103-020-03241-6

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  • Laser
  • Periorbital
  • Infraorbital
  • Dark eye circle
  • Pigmentation
  • Darkness, systematic review