Lasers in Medical Science

, Volume 33, Issue 8, pp 1813–1819 | Cite as

Treatment of mucositis with combined 660- and 808-nm-wavelength low-level laser therapy reduced mucositis grade, pain, and use of analgesics: a parallel, single-blind, two-arm controlled study

  • Raquel Gusmão Soares
  • Lucyana Conceição Farias
  • Agna Soares da Silva Menezes
  • Carla Silvana de Oliveira e Silva
  • Angeliny Tamiarana Lima Tabosa
  • Pablo Vinicyus Ferreira Chagas
  • Laís Santiago
  • Sérgio Henrique Sousa Santos
  • Alfredo Maurício Batista de Paula
  • André Luiz Sena Guimarães
Original Article


Oral squamous cell carcinoma (OSCC) is the most frequent oral malignant neoplasia. As consequence of OSCC treatment, oral mucositis (OM) is one of the most common adverse effects of OSCC treatment. Currently, there is no consensus for OM treatment. The purpose of the current study was to test the combination of red and infrared low-level laser therapy (LLLT) for OM treatment. Primary culture of human fibroblast was performed to identify LLLT dose. After laboratory tests, a two-arm parallel, single-blind, controlled study was conducted. The two arms were group 1, both 660- and 808-nm wavelengths (300 J/cm2, 9 J of total energy, 100 mW, spot size 3 mm2), and group 2, only 660-nm wavelength (300 J/cm2, 9 J of total energy, 100 mW, spot size 3 mm2). Both treatments were performed twice a week. Group 1 presented a reduction of mucositis grade in comparison to group 2. Group 1 also presented reduction of analgesics prescription. But no significant differences between groups 1 and 2 were observed according to the pain scale. In conclusion, the current study demonstrated that a combination of red and infrared at a higher dose (300 J/cm2) reduced both oral mucositis grade and analgesics prescription. The effects of the combination of RT and LLLT are unclear and need more studies.


LASER Light therapy LED Phototherapy Radiation Cancer Pain Mouth 



Dr. Guimarães, Dr. Dr. Santos, and Dr. de Paula are research fellows of the CNPq. Dr. Farias is a research fellow of FAPEMIG.

Funding information

This study was supported by grants from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), and the Fundação de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Ethical approval for this study was obtained from the relevant Institutional Review Board (48215415.0.0000.5146). The study was also registered in National Clinical Trials (UTN: U1111-1177-9023/67hjmn).

Informed consent

All patients signed informed consent.


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2018

Authors and Affiliations

  • Raquel Gusmão Soares
    • 1
  • Lucyana Conceição Farias
    • 1
  • Agna Soares da Silva Menezes
    • 1
  • Carla Silvana de Oliveira e Silva
    • 2
  • Angeliny Tamiarana Lima Tabosa
    • 1
  • Pablo Vinicyus Ferreira Chagas
    • 1
  • Laís Santiago
    • 3
  • Sérgio Henrique Sousa Santos
    • 4
  • Alfredo Maurício Batista de Paula
    • 1
  • André Luiz Sena Guimarães
    • 1
    • 3
    • 5
  1. 1.Department of DentistryUniversidade Estadual de Montes Claros (Unimontes)Montes ClarosBrazil
  2. 2.Department of NursyUniversidade Estadual de Montes Claros (Unimontes)Montes ClarosBrazil
  3. 3.Dilson Godinho HospitalMontes ClarosBrazil
  4. 4.Institute of Agricultural SciencesUniversidade Federal de Minas Gerais (UFMG)Montes ClarosBrazil
  5. 5.Universidade Estadual de Montes Claros, Laboratório de Pesquisa em SaúdeHospital Universitário Clemente FariaMontes ClarosBrazil

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