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Electroretinogram evaluation for the treatment of proliferative diabetic retinopathy by short-pulse pattern scanning laser panretinal photocoagulation

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A Correction to this article was published on 28 April 2018

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Abstract

Panretinal photocoagulation (PRP) is a standard method for proliferative diabetic retinopathy (PDR) treatment. However, conventional PRP usually significantly damages the retinal structure and vision. Retinal pattern scanning laser (PASCAL) photocoagulation has emerged as a new technique with fewer complications for the treatment of retinal disorders. This study compares the therapeutic effects of short-pulse PASCAL to conventional single-spot PRP for PDR. Fifty-two PDR patients (104 eyes) were randomly assigned into a short-pulse PASCAL-PRP treatment (SP) group and a conventional PRP treatment (TP) group. The best corrected visual acuity (BCVA) and full-field flash electroretinogram (ERG) data were evaluated before and after the two treatments. The BCVA data between before and after the PRP treatments did not show any significant difference. After the PRP treatment, the b-wave amplitude (b-A) in the dark-adapted 3.0 ERG (p = 0.0005) and the amplitude in the light-adapted 3.0 flicker ERG (p = 0.009) were significantly higher in the SP group compared with that of the TP group. In addition, after the PRP treatment, the a-wave implicit time (a-T) of light-adapted 3.0 ERG prolonged significantly in the TP group compared to the SP group. Compared with the parameters before the treatments, the a-A and b-A under dark-adapted 3.0 ERG and the b-A under the light-adapted 3.0 ERG in both TP and SP groups after the treatments decreased significantly (p < 0.05). Short-pulse PASCAL-PRP significantly attenuated partial vision damage compared to conventional PRP, although it still caused limited retinal injury and mild reduction in retinal function. These findings suggest that short-pulse PASCAL-PRP is a promising technique for PDR treatment.

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Change history

  • 28 April 2018

    The published online version contains incorrect data in Table 2 caption. Argon should not be mentioned in the caption as this is not used in this paper.

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Funding

This project was funded by Sun Yat-Sen University Clinical Research 5010 Project (2013007) and the Major Project of Guangzhou Science and Technology Committee (201707020008).

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Authors and Affiliations

  1. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, No. 54 South Xianlie Road, Guangzhou, Guangdong, 510060, China

    Haiyun Ye, Minzhong Yu, Lin Lu, Chenjin Jin & Guangwei Luo

  2. Department of Ophthalmology, Shanghai Children’s Hospital, Shanghai Jiao Tong University, Shanghai, 200060, China

    Haiyun Ye

  3. Department of Ophthalmology, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, United States

    Minzhong Yu

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  1. Haiyun Ye
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  2. Minzhong Yu
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  3. Lin Lu
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  4. Chenjin Jin
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  5. Guangwei Luo
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Correspondence to Chenjin Jin or Guangwei Luo.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Ye, H., Yu, M., Lu, L. et al. Electroretinogram evaluation for the treatment of proliferative diabetic retinopathy by short-pulse pattern scanning laser panretinal photocoagulation. Lasers Med Sci 33, 1095–1102 (2018). https://doi.org/10.1007/s10103-018-2474-0

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  • DOI: https://doi.org/10.1007/s10103-018-2474-0

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