Transcranial near-infrared photobiomodulation could modulate brain electrophysiological features and attentional performance in healthy young adults
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The aim of the present study was to investigate the electrophysiological effects of the photobiomodulation (PBM) by the quantitative electroencephalography (qEEG) as a diagnostic method. The neurotherapeutic potential of transcranial PBM has been recently investigated in preclinical and clinical studies. According to the PBM mechanisms of action on increasing the cerebral blood flow and the neuronal firing, a change may occur in cortical electrical activity after transcranial PBM that could be revealed in qEEG. A total of 30 participants (15 males and 15 females) were included in this experimental study in a convenience sampling method. A 19-channel EEG was obtained from subjects, before and after receiving sham or real 850-nm PBM by light emitting diode (LED) array on the right prefrontal cortex (PFC). An attentional task also was completed by the participant before and after the irradiation. Results presented that the effect of PBM on the reaction time was significant (p = 0.001) in favor of the real-treatment group (p < 0.05). For the absolute power, repeated-measures ANOVA showed a significant interaction of group × time × frequency (p = 0.04). In the real-treatment group, absolute power of delta band was significantly reduced in all electrodes (p < 0.05). Also, a similar significant interaction of group × time × frequency was seen for relative power (p = 0.04). Post-hoc analysis showed a significant decrease in delta band after PBM in the real treatment group (p < 0.05). The study presented that light irradiation with 850-nm LED source on right PFC could change brain electrical activity and has beneficial effects on attentional performance.
KeywordsTranscranial Near-infrared Photobiomodulation Attentional performance Quantitative electroencephalogram
The authors would like to thank Dr. Hassan Sabouri who helped in editing the manuscript.
Compliance with ethical standards
The study was approved by the Regional Ethical Committee of Tabriz University of Medical Sciences and all procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments.
Conflict of interest
The authors declare that they have no conflict of interest.
Research involving human participants
The study was approved by the Regional Ethical Committee of Tabriz University of Medical Sciences (No: IR.TBZMED.RCE.1395.687).
Informed consent was obtained from all participants included in the study.
- 1.Salehpour F, Mahmoudi J, Kamari F, Sadigh-Eteghad S, Rasta SH, Hamblin MR (2018) Brain photobiomodulation therapy: a narrative review. Mol Neurobiol 55(8):6601–36Google Scholar
- 2.Yue L, Monge M, Ozgur MH, Murphy K, Louie S, Miller CA, Emami A , Humayun MS (2015) Simulation and measurement of transcranial near infrared light penetration. In Optical Interactions with Tissue and Cells XXVI, (Vol. 9321, p 3210S–93216). https://doi.org/10.1117/12.2077019
- 6.Salgado S, Parreira R, Ceci L, de Oliveira L, Zangaro R (2015) Transcranial light emitting diode therapy (TCLT) and its effects on neurological disorders. J Bioeng Biomed Sci 5(1):1Google Scholar
- 7.Saltmarche AE, Naeser MA, Ho KF, Hamblin MR, Lim L (2017) Significant improvement in cognition in mild to moderately severe dementia cases treated with transcranial plus intranasal photobiomodulation: case series report. Photomed Laser Surg 35(8):432–441. https://doi.org/10.1089/pho.2016.4227 CrossRefPubMedPubMedCentralGoogle Scholar
- 8.Moghadam Sabouri H, Nazari MA, Jahan A, Mahmoudi J, Salimi MM (2017) Beneficial effects of transcranial light emitting diode (LED) therapy on attentional performance: an experimental design. Iran Red Crescent Med J 19(5):e44513Google Scholar
- 9.Berman MH, Halper JP, Nichols TW, Jarrett H, Lundy A, Huang JH (2017) Photobiomodulation with near infrared light helmet in a pilot, placebo controlled clinical trial in dementia patients testing memory and cognition. J Neurol Neurosci 8(1)Google Scholar
- 11.Hamblin MR (2017) Mechanisms and mitochondrial redox signaling in photobiomodulation. Photochem Photobiol 94(2):199–212Google Scholar
- 14.da Luz Eltchechem C, Salgado ASI, Zangaro RA, da Silva Pereira MC, Kerppers II, da Silva LA, Parreira RB (2017) Transcranial LED therapy on amyloid-beta toxin 25-35 in the hippocampal region of rats. Lasers Med Sci 32(4):749–756. https://doi.org/10.1007/s10103-017-2156-3 CrossRefPubMedGoogle Scholar
- 15.Hamblin MR (2017) Photobiomodulation for stroke. In: Lapchak PA, Yang YG (eds) Translational research in stroke. Springer, Singapore, pp 397–441Google Scholar
- 18.Hwang J, Castelli DM, Gonzalez-Lima F (2016) Cognitive enhancement by transcranial laser stimulation and acute aerobic exercise. Lasers Med Sci:1–10Google Scholar
- 19.Blanco NJ, Maddox WT, Gonzalez-Lima F (2015) Improving executive function using transcranial infrared laser stimulation. J Neuropsychol 11(1):14–25Google Scholar
- 20.Gonzalez-Lima F, Barrett DW (2014) Augmentation of cognitive brain functions with transcranial lasers. Front Syst Neurosci 14:8–36Google Scholar
- 24.Wang X, Dmochowski J, Husain M, Gonzalez-Lima F, Liu H (2017) Proceedings# 18. Transcranial infrared brain stimulation modulates EEG alpha power. Brain Stimulation 10(4):e67–e69Google Scholar
- 26.Averbukh LD (2013) Exploring the link between drug addiction propensity and improper top-down control in sustained attention tasks. Dissertation, University of MichiganGoogle Scholar
- 29.Arciniegas DB, Anderson CA, Filley CM (2013) Behavioral neurology & neuropsychiatry. Cambridge University Press, New YorkGoogle Scholar
- 34.Salehpour F, Farajdokht F, Erfani M, Sadigh-Eteghad S, Shotorbani SS, Hamblin MR, Karimi P, Rasta SH, Mahmoudi J (2018) Transcranial near-infrared photobiomodulation attenuates memory impairment and hippocampal oxidative stress in sleep-deprived mice. Brain Res 1682:36–43Google Scholar
- 38.Ingvar D, Sulg I (1969) Regional cerebral blood flow and EEG frequency content in man. Scand J Clin Invest 23(Suppl 109):47–66Google Scholar