Clean Technologies and Environmental Policy

, Volume 19, Issue 3, pp 869–882 | Cite as

Biosynthesis of lactic acid in a membrane bioreactor for cleaner technology of polylactide production

  • A. Kuznetsov
  • A. Beloded
  • A. Derunets
  • V. Grosheva
  • L. Vakar
  • R. Kozlovskiy
  • V. Shvets
Original Paper


A low-waste and high intensive method of lactic acid microbial synthesis for polylactide production has been developed. The biosynthesis proceeds at the semicontinuous cultivation in a membrane bioreactor without removal of the biomass and formation of excess of biomass of the lactic acid producer, with minimization of the consumption of expensive growth factors. At the laboratory experiments during 130 cycles on biosynthesis of lactic acid from glucose in a membrane reactor, the specific productivity of biochemical reactor reached 46 g of LA per liter per hour at the yield of LA from glucose close to 100 % and concentration of LA 100–120 g/L. These results are a good base for development of the cleaner technology for production of chemicals from renewable sources through lactic acid.


Renewable sources Biosynthesis Lactic acid Membrane bioreactor 



This work was supported by the Ministry of Education and Science of Russia (Project ID 17 RFMEFI57714X0037).


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of BiotechnologyD. Mendeleev University of Chemical Technology of RussiaMoscowRussia
  2. 2.Department of Petrochemical SynthesisD. Mendeleev University of Chemical Technology of RussiaMoscowRussia

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