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Clean Technologies and Environmental Policy

, Volume 19, Issue 3, pp 869–882 | Cite as

Biosynthesis of lactic acid in a membrane bioreactor for cleaner technology of polylactide production

  • A. Kuznetsov
  • A. Beloded
  • A. Derunets
  • V. Grosheva
  • L. Vakar
  • R. Kozlovskiy
  • V. Shvets
Original Paper

Abstract

A low-waste and high intensive method of lactic acid microbial synthesis for polylactide production has been developed. The biosynthesis proceeds at the semicontinuous cultivation in a membrane bioreactor without removal of the biomass and formation of excess of biomass of the lactic acid producer, with minimization of the consumption of expensive growth factors. At the laboratory experiments during 130 cycles on biosynthesis of lactic acid from glucose in a membrane reactor, the specific productivity of biochemical reactor reached 46 g of LA per liter per hour at the yield of LA from glucose close to 100 % and concentration of LA 100–120 g/L. These results are a good base for development of the cleaner technology for production of chemicals from renewable sources through lactic acid.

Keywords

Renewable sources Biosynthesis Lactic acid Membrane bioreactor 

Notes

Acknowledgments

This work was supported by the Ministry of Education and Science of Russia (Project ID 17 RFMEFI57714X0037).

References

  1. Abdel-Rahman MA, Tashiro Y, Sonomoto K (2013) Recent advances in lactic acid production by microbial fermentation processes. Biotechnol Adv 31:877–902CrossRefGoogle Scholar
  2. Adamberg K, Lahtvee PJ, Valgepea K, Abner K, Vilu R (2009) Quasi steady state growth of Lactococcus lactis in glucose-limited acceleration stat (Astat) cultures. Antonie Van Leeuwenhoek J Microb 95:219–226CrossRefGoogle Scholar
  3. Basile A (ed) (2013) Handbook of membrane reactors 2: reactor types and industrial applications. Woodhead Publishing Ltd, SawstonGoogle Scholar
  4. Chen X, Zhang BB, Wang YL, Luo YF, Wang RG, Ren HQ (2012) Production of l-lactic acid from corn starch hydrolysate by immobilized Rhizopus oryzae on a new asterisk-shaped matrix. Adv Mater Res 347–353:1193–1197Google Scholar
  5. Chronopoulos G, Bekatorou A, Bezirtzoglou E, Kaliafas A, Koutinas A, Marchant R (2002) Lactic acid fermentation by Lactobacillus casei in free cell form and immobilised on gluten pellets. Biotechnol Lett 24(15):1233–1236CrossRefGoogle Scholar
  6. Coelho LF, de Lima CJB, Rodovalho CM, Bernardo MP, Contiero J (2011) Lactic acid production by new Lactobacillus plantarum LMISM6 grown in molasses: optimisation of medium composition. Braz J Chem Eng 28(01):27–36CrossRefGoogle Scholar
  7. Corma A, Iborra S, Velty A (2007) Chemical routes for the transformation of biomass into chemicals. Chem Rev 107:2411–2502CrossRefGoogle Scholar
  8. Danner H, Madzingaidzo L, Thomasser C, Neureiter M, Braun R (2002) Thermophilic production of lactic acid using integrated membrane bioreactor systems coupled with monopolar electrodialysis. Appl Microbiol Biotechnol 59:160–169CrossRefGoogle Scholar
  9. Datta R, Henry M (2006) Lactic acid: recent advances in products, processes and technologies—a review. J Chem Technol Biotechnol 81:1119–1129CrossRefGoogle Scholar
  10. Dey P, Pal P (2012) Direct production of L(+) lactic acid in a continuous and fully membrane-integrated hybrid reactor system under non-neutralizing conditions. J Membr Sci 389:355–362CrossRefGoogle Scholar
  11. Dusselier M, van Wouwe P, Dewaele A, Makshina E, Sels BF (2013) Lactic acid as a platform chemical in the biobased economy: the role of chemocatalysis. Energy Environ Sci 6:1415–1442CrossRefGoogle Scholar
  12. Gao M-T, Michiteru K, Rie G, Hirokazu T, Makoto H, Tadashi H (2005) Development of a continuous electrodialysis fermentation system for production of lactic acid by Lactobacillus rhamnosus. Process Biochem 40:1033–1036CrossRefGoogle Scholar
  13. Giorno L, Chojnacka K, Donato L, Drioli E (2002) Study of a cell-recycle membrane fermentor for the production of lactic acid by Lactobacillus bulgaricus. Ind Eng Chem Res 41(3):433–440CrossRefGoogle Scholar
  14. Gonzalves LMD, Ramos A, Almeida JS, Xavier AMRB, Carrondo MJT (1997) Elucidation of the mechanism of lactic acid growth inhibition and production in batch cultures of Lactobacillus rhamnosus. Appl Microbiol Biotechnol 48:346–350CrossRefGoogle Scholar
  15. Hai FI, Yamamoto K, Lee C-H (eds) (2014) Membrane biological reactors. Theory, modeling, design, management and applications to wastewater reuse. IWA Publishing, LondonGoogle Scholar
  16. Hongpattarakere T, Cherntong N, Wichienchot S et al (2012) In vitro prebiotic evaluation of exopolysaccharides produced by marine isolated lactic acid bacteria. Carbohydr Polym 87:846–852CrossRefGoogle Scholar
  17. Ishida N, Saitoh S, Tokuhiro K, Nagamori E, Matsuyama T, Kitamoto K et al (2005) Efficient production of L-lactic acid by metabolically engineered Saccharomyces cerevisiae with a genome-integrated L-lactate dehydrogenase gene. Appl Environ Microbiol 71(4):1964–1970CrossRefGoogle Scholar
  18. Itoh Y, Tada K, Kanno T, Horiuchi J (2012) Selective production of lactic acid in continuous anaerobic acidogenesis by extremely low pH operation. J Biosci Bioeng 114:537–539CrossRefGoogle Scholar
  19. Iyer PV, Lee YY (1999) Simultaneous saccharification and extractive fermentation of lignocellulosic materials into lactic acid in a two-zone fermentor-extractor system. Appl Biochem Biotechnol 78:409–419CrossRefGoogle Scholar
  20. Juturu V, Wu J-C (2015) Microbial production of lactic acid: the latest development. Crit Rev Biotechnol. doi: 10.3109/07388551.2015.1066305 Google Scholar
  21. Kim D-H, Lim W-T, Lee M-K, Kim M-S (2012) Effect of temperature on continuous fermentative lactic acid (LA) production and bacterial community, and development of LA-producing UASB reactor. Bioresour Technol 119:355–361CrossRefGoogle Scholar
  22. Kim D-H, Lee M-K, Moon C, Yun Y-M, Lee W-T, Ohe S-E, Kim M-S (2014) Effect of hydraulic retention time on lactic acid production and granulation in an up-flow anaerobic sludge blanket reactor. Bioresour Technol 165:158–161CrossRefGoogle Scholar
  23. Kim D-H, Lee M-K, Hwang Y, Im W-T, Yun Y-M, Park C, Kim M-S (2016) Microbial granulation for lactic acid production. Biotechnol Bioeng 113:101–111CrossRefGoogle Scholar
  24. Kwon S, Yoo IK, Lee WG, Chang HN, Chang YK (2001) High-rate continuous production of lactic acid by Lactobacillus rhamnosus in a two-stage membrane cell-recycle bioreactor. Biotechnol Bioeng 73:25–34CrossRefGoogle Scholar
  25. Lee RK, Ryu HW, Oh H, Kim M, Wee YJ (2014) Cell-recycle continuous fermentation of Enterococcus faecalis RKY1 for economical production of lactic acid by reduction of yeast extract supplementation. J Microbiol Biotechnol 24:661–666CrossRefGoogle Scholar
  26. Li Q-Z, Jiang X-L, Feng X-J, Wang J-M, Sun C, Zhang H-B, Xian M, Liu H-Z (2015) Recovery processes of organic acids from fermentation broths in the biomass-based industry. J Microbiol Biotechnol. doi: 10.4014/jmb.1505.05049 Google Scholar
  27. Liu B, Yang M, Qi B, Chen X, Su Z, Wan Y (2010) Optimizing l-(+)-lactic acid production by thermophile Lactobacillus plantarum As.1.3 using alternative nitrogen sources with response surface method. Biochem Eng J 52:212–219CrossRefGoogle Scholar
  28. Lu Z, Wei M, Yu L (2012) Enhancement of pilot scale production of L-(+)-lactic acid by fermentation coupled with separation using membrane bioreactor. Process Biochem 47:410–415CrossRefGoogle Scholar
  29. Lunelli BH, Andrade RR, Atala DIP, Wolf MMR, Maugeri FF, Maciel FR (2010) Production of lactic acid from sucrose: strain selection, fermentation and kinetic modeling. Appl Biochem Biotechnol 161:227–237CrossRefGoogle Scholar
  30. Makras L, Van Acker G, De Vuyst L (2005) Lactobacillus paracasei subsp. paracasei 8700:2 degrades inulin-type fructans exhibiting different degrees of polymerization. Appl Environ Microbiol 71:6531–6537CrossRefGoogle Scholar
  31. Martinez FAC, Balciunas EM, Salgado JM, González JMD, Converti A, Oliveira RPS (2013) Lactic acid properties, applications and production: a review. Trends Food Sci Technol 30:70–83CrossRefGoogle Scholar
  32. Monteagudo JM, Aldavero M (1999) Production of L-lactic acid by Lactobacillus delbrueckii in chemostat culture using an ion exchange resins system. J Chem Technol Biotechnol 74:627–634CrossRefGoogle Scholar
  33. Nakanishi K, Ueno T, Sato S, Yoshi S (2010) L-lactic acid production from canned pineapple syrup by rapid sucrose catabolizing Lactobacillus paracasei NRIC 0765. Food Sci Technol Res 16(3):239–246CrossRefGoogle Scholar
  34. Nguyen CM, Kim J-S, Hwang HJ, Park MS, Choi GJ, Choi YH, Jang KS, Kim J-C (2012) Production of L-lactic acid from a green microalga, Hydrodictyon reticulum, by Lactobacillus paracasei LA104 isolated from the traditional Korean food, makgeolli. Bioresour Technol 110:552–559CrossRefGoogle Scholar
  35. Nolasco-Hipolito C, Zarrabal OC, Kamaldin RM, Teck-Yee L, Lihan S, Bujang KB (2012) Lactic acid production by Enteroccocus faecium in liquefied sago starch. AMB Express 2(1):1–9CrossRefGoogle Scholar
  36. Okano K, Tanaka T, Ogino C (2010) Biotechnological production of enantiomeric pure lactic acid from renewable resources: recent achievements, perspectives, and limits. Appl Microbiol Biotechnol 85:413–423CrossRefGoogle Scholar
  37. Pal P, Sikder J, Roy S, Giorno L (2009) Process intensification in lactic acid production: a review of membrane based processes. Chem Eng Process Process Intensif 48:1549–1559CrossRefGoogle Scholar
  38. Pang X, Zhuang X, Tang Z, Chen X (2010) Polylactic acid (PLA): research, development and industrialization. Biotechnol J 5(11):1125–1136CrossRefGoogle Scholar
  39. Petrova P, Petrov K (2012) Direct starch conversion into L-(+)-lactic acid by a novel amylolytic strain of Lactobacillus paracasei B41. Starch 64:10–17CrossRefGoogle Scholar
  40. Priyananda P, Chen V (2006) Flux decline during ultrafiltration of protein–fatty acid mixtures. J Membr Sci 273:58–67CrossRefGoogle Scholar
  41. Ramchandran L, Sanciolo P, Vasiljevic T, Broome M, Powell I, Duke M (2012) Improving cell yield and lactic acid production of Lactococcus lactis ssp. Cremoris by a novel submerged membrane fermentation process. J Membr Sci 403–404:179–187CrossRefGoogle Scholar
  42. Rasal RM, Janorkar AV, Hirt DE (2010) Poly(lactic acid) modifications. Prog Polym Sci 35:338–356CrossRefGoogle Scholar
  43. Richter K, Nottelmann S (2004) An empiric steady state model of lactate production in continuous fermentation with total cell retention. Eng Life Sci 4:426–432CrossRefGoogle Scholar
  44. Rivas B, Moldes AB, Dominguez JM, Parajo JC (2004) Development of culture media containing spent yeast cells of Debaryomyces hansenii and corn steep liquor for lactic acid production with Lactobacillus rhamnosus. Int J Food Microbiol 97:93–98CrossRefGoogle Scholar
  45. Sauer M, Porro D, Mattanovich D, Branduardi P (2010) 16 years research on lactic acid production with yeast—ready for the market? Biotechnol Genet Eng Rev 27:229–256CrossRefGoogle Scholar
  46. Schepers AW, Thibault J, Lacroix C (2006) Continuous lactic acid production in whey permeate/yeast extract medium with immobilized Lactobacillus helveticus in a twostage process: model and experiments. Enzyme Microb Technol 38(3–4):324–337CrossRefGoogle Scholar
  47. Schiraldy C, Adduci V, Valli V, Maresca C, Guiliano M, Lamberti M, Carteni M, De Rosa M (2003) High cell density cultivation of probiotics and lactic acid production. Biotechnol Bioeng 82:213–222CrossRefGoogle Scholar
  48. Sirisansaneeyakul S, Luangpipat T, Vanichsriratana W, Srinophakun T, Chen HHH, Chisti Y (2007) Optimization of lactic acid production by immobilized Lactococcus lactis IO-1. J Ind Microbiol Biotechnol 34(5):381–391CrossRefGoogle Scholar
  49. Tashiro Y, Kaneko W, Sun Y, Shibata K, Inokuma K, Zendo T, Sonomoto K (2011) Continuous D-lactic acid production by a novel thermotolerant Lactobacillus delbrueckii subsp. lactis QU 41. Appl Microbiol Biotechnol 89:1741–1750CrossRefGoogle Scholar
  50. US pat 8551745 (2013) Method of producing lactic acid by continuous fermentationGoogle Scholar
  51. US pat 7682814 (2010) Method for producing lactic acid with high concentration and high yield using lactic acid bacteriaGoogle Scholar
  52. Van Beuzekom B, Arundel A (2009) OECD biotechnology statistics 2009. OECD, ParisGoogle Scholar
  53. Vijayakumar J, Aravindan R, Viruthagiri T (2008) Recent trends in the production, purification and application of lactic acid. Chem Biochem Eng Q 22(2):245–264Google Scholar
  54. Vodnar DC, Venus J, Schneider R, Socaciu C (2010) Lactic acid production by Lactobacillus paracasei 168 in discontinuous fermentation using lucerne green juice as nutrient substitute. Chem Eng Technol 33:468–474CrossRefGoogle Scholar
  55. Vodnar DC, Dulf FV, Pop OL, Socaciu C (2013) L(+)-lactic acid production by pellet form Rhizopus oryzae NRRL 395 on biodiesel crude glycerol. Microb Cell Fact 12:92CrossRefGoogle Scholar
  56. Wee YJ, Yun JS, Lee Y, Zeng AP, Ryu HW (2005) Recovery of lactic acid by repeated batch electrodialysis and lactic acid production using electrodialysis wastewater. J Biosci Bioeng 99:104–108CrossRefGoogle Scholar
  57. Wee YJ, Kim JN, Ryu HW (2006) Biotechnological production of lactic acid and its recent applications. Food Technol Biotechnol 44:163–172Google Scholar
  58. Xu G-Q, Chu J, Wang Y-H, Zhuang Y-P, Zhang S-L, Peng H-Q (2006) Development of a continuous cell-recycle fermentation system for production of lactic acid by Lactobacillus paracasei. Process Biochem 41:2458–2463CrossRefGoogle Scholar
  59. Xu G-Q, Chu J, Zhuang Y-P, Wang Y-H, Zhang S-L (2008) Effects of vitamins on the lactic acid biosynthesis of Lactobacillus paracasei NERCB 0401. Biochem Eng J 38:189–197CrossRefGoogle Scholar
  60. Yamane T, Tanaka R (2013) Highly accumulative production of L(+)-lactate from glucose by crystallization fermentation with immobilized Rhizopus oryzae. J Biosci Bioeng 115(1):90–95CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of BiotechnologyD. Mendeleev University of Chemical Technology of RussiaMoscowRussia
  2. 2.Department of Petrochemical SynthesisD. Mendeleev University of Chemical Technology of RussiaMoscowRussia

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