To identify differences in perception on multi-drug-resistant (MDR) organisms and their management at intensive care units (ICU). A cross-sectional survey was conducted. A proposal addressing a pathogen priority list (PPL) for ICU, arising from the TOTEM study, was compared with a sample of global experts in infections in critically ill patients. The survey was responded by 129 experts. Globally, ESBL Enterobacteriaceae, followed by carbapenem-resistant Acinetobacter baumannii and carbapenem-resistant Klebsiella pneumoniae, were the main concerns. Some differences in opinion were identified between 63 (49%) ICU physicians (ICU/anesthesiology) and 43 (33%) infectious disease consultants (ID physicians/microbiologists). The pathogens most concerning in the ICU for intensivists were ESBL Enterobacteriaceae (38%) versus carbapenem-resistant A. baumannii (48.3%) for ID consultants, (p < 0.05). Increasing number of ID consultants over intensivists (26% vs 14%) reported difficulty in choosing initial therapy for carbapenem-resistant A. baumannii. For intensivists, the urgent measures to limit development of antibiotic resistance were headed by cohort measures (26.3%) versus increasing nurse/patient ratio (32.5%) for ID consultants, (p < 0.05). Regarding effectiveness to prevent MDR development and spread, education programs (42.4%) were the priority for intensivists versus external consultation (35.7%) for ID consultants. Finally, both groups agreed that carbapenem resistance was the most pressing concern (> 70%) regarding emerging resistance. Differences in priorities regarding organisms, infection control practices, and educational priorities were visualized between ID/clinical microbiologists and ICU/anesthesiologists. Multi-disciplinary collaboration is required to achieve best care for ICU patients with severe infections.
The World Health Organization (WHO) proposed a global priority pathogen list (PPL) of multidrug-resistant (MDR) bacteria . However, critically ill patients are particularly susceptible to infections arising from MDR bacteria , and a critical care specific list of PPL has been recently reported in TOTEM study . The scope was to identify the most important resistant bacteria for intensive care units (ICU) and their challenges. In this cross-sectional survey, we assessed whether these perceptions were validated by a global sample of professionals with expertise in severe infections. The secondary objective was to prioritize the list to focus efforts proportionately according to perceived clinical need. The hypothesis was that differences in perception on MDR organisms and their management occur and might be associated with the primary training background and geographic differences.
A steering committee (Appendix 2) with experience of identification, prevention, and treatment of MDR bacteria in critically ill patients developed and refined the study protocol and selection of pathogens. Mycobacteria, rickettsia, viruses, and parasites were excluded. MDR bacteria was defined as non-susceptibility to at least one agent in ≥ 3 antimicrobial categories . The study group was represented by intensivists, anesthesiologists, clinical microbiologists, and infectious disease (ID) consultants with experience in ICU settings (Table S1, supplemental material). Pediatric and neonatal intensive care units (ICUs) were excluded.
The survey was performed using an electronic platform (SurveyMonkey®) and was distributed by invitation from members of the Steering Committee in February 2018. The survey was an online questionnaire requiring no patient-specific data, and thus, the need for research ethics committee approval and informed consent were waived. The study protocol and questionnaire were published elsewhere .
Analysis by Chi-square test (or Fisher’s exact test when appropriate) was performed to evaluate potential associations. A two-tailed P value less than 0.05 was considered statistically significant.
The cross-sectional survey was completed by 129 respondents. The overall representation from within and outside Europe was 54% and 46% while the ICU practitioners (intensivists and anesthesiologists) constituted for 58% and 42%, respectively. Distribution according to regions, respondents, and IC characteristics are listed in Tables S1 and S2 (supplemental material).
Globally, extended spectrum beta-lactamase (ESBL) Enterobacteriaceae, followed by carbapenem-resistant (CR) Acinetobacter baumannii and CR Klebsiella pneumoniae were the main concerns. The mortality rankings of the organisms, therapy concerns, and opinion on measures to prevent emergence and spread of MDR are detailed in Table 1. Some differences in opinion were identified between 63 (49%) ICU physicians (ICU/anesthesiology) and 43 (33%) infectious disease consultants (ID physicians/microbiologists) (Table 1). The pathogens most concerning in the ICU for intensivists were ESBL Enterobacteriaceae (38%) versus CR A. baumannii (48.3%) for ID consultants, (p < 0.05). Increasing number of ID consultants over intensivists (26% vs 14%) reported difficulty in choosing initial therapy for CR A. baumannii. For intensivists, the urgent measures to limit development of antibiotic resistance were headed by cohort measures (26.3%) versus increasing nurse/patient ratio (32.5%) for ID consultants (p < 0.05). Regarding effectiveness to prevent MDR development and spread, education programs (42.4%) were the priority for intensivists versus external consultation (35.7%) for ID consultants. Finally, both groups agreed that carbapenem resistance was the most pressing concern regarding emerging resistance (72.9% versus 77.5%, p > 0.20). All these results are detailed in Table 1.
Global top five organism by site and differences between geographic regions ranks according most common sites involving MDR pathogens in ICUs are shown in Table 2. The details of practiced preventive measures to limit the MDR organisms are reported in Tables S1 and S2, supplemental section.
Our findings emphasize the global concern regarding Gram-negative bacteria, although Gram-positive organisms dominated concern regarding community-acquired pneumonia and CSSI. Differences between intensivists and ID/clinical microbiologists and regional differences in priority pathogens and strategies are important observations.
Carbapenem-resistant organisms were indisputably perceived as highest threat for mortality, treatability, and cost. In addition, the results support the difficulty faced in managing MDR P. aeruginosa infections in ICUs . Mortality by CR organisms is contributed particularly by the non-availability of effective drugs rather than increased virulence [7,8,9]. Adequacy of antimicrobial therapy, but not pathogen resistance pattern, impacted attributable mortality thus indicating the grim situation arising from the failing antibiotic pipeline . The increased risk of mortality was strongly evident in Asia  with variations in carbapenemase production across different regions . Currently, the biggest gap exists in the investigational pipeline for compounds active against CR A. baumannii. Our findings suggest that this organism is of major concern, despite it being conventionally considered low virulence .
Importantly, issues contributing to misuse of existing antibiotics need serious attention. Lack of suitable rapid diagnostics and non-availability in a timely manner is a major impediment in appropriately using antibiotics [14, 15]. Our survey reinforces the differential prevalence of MDR bacteria by site of infection and the importance of recording this when undertaking surveillance programs.
WHO reports estimate that approximately 30% of ICU patients are affected by at healthcare-associated infections . Several reports suggest the lack of surveillance data having a negative influence on the implementation of preventive measures [17,18,19,20,21]. Two world-wide ICU infection prevalence studies in a span of 10 years have demonstrated 20% increase in prevalence [22, 23]. Accompanying this rise in infections is a parallel increase in antimicrobial resistance rates, thus changing the status from MDR to extreme drug resistance (XDR).
We identified apparent differences in resistant organism prevalence by site of infection and geographic location. MRSA was increasingly common in CSSIs and device-related BSIs. Among Asian participants, CR K. pneumoniae was the second most commonly reported cause of device-related BSIs. Macrolide-resistant S. pneumoniae was perceived with lower priority in America, perhaps because the predominant mechanism of resistance is different from other regions. Similarly, CR K. pneumoniae was perceived as more important in Africa. Regional priorities for different infectious sites were reported to be similar among participants with minimal variations. Interestingly, few participants in the survey felt that adequate initial treatment for CR P. aeruginosa was difficult, although this organism featured in the top four priority organisms in the preceding MCDA analysis . This difference might be due to the perception of availability of colistin and aminoglycosides for therapy, despite recent evidence suggesting that the efficacy of these choices is similar to inappropriate therapy in clinical practice .
Overall, the current opinion from the survey highlights the dominant burden of Gram-negative bacterial infections over the Gram-positive infection in critical care settings. Although rates of MRSA bacteremia are declining in Europe, the occurrence of SSIs and other serious infections by MRSA are still high . USA reports the opposite trend that is observed in Europe . Our results reflect these trends, likely due to higher representation of European colleagues.
Our results bring attention to the variations in opinions of intensive care and ID physicians about issues such as occurrence, management, and containment of MDR infections in ICUs that might have implications on patient care. However, there was an overall consensus on components of antimicrobial stewardship (AMS) and infection prevention measures for confronting MDR infections. Interestingly, intensivists did not consider ID consultation as a priority measure to reduce antimicrobial resistance. The difference in perception might probably arise due to the non-availability of ID round the clock and their focus on the overall patient status rather than the antibiotic resistance and selection pressures. Moreover, the difficulty in differentiating colonization and true infection also contributes to differences in perceptions towards management of MDR organisms which could not be assessed in the current survey.
There are several limitations to this study. Although survey respondents came from across the globe, they represent only a small fraction of clinicians and units care for critically ill patients and universal coverage of nations was not achieved. National representation did not correlate with relative population size, and we could not assess regional variation in MDR bacteria at a national or regional level. Neither were we able to examine differences between patient types (for instance cardiac, burns, or neuro-trauma) and our findings are restricted to adult populations. Although our survey was largely focused on health-care-acquired infections, community-acquired MDR organisms in pneumonia were enquired about although not community-acquired infections at other sites.
The pathogens most concerning in the ICU for intensivists were ESBL Enterobacteriaceae versus CR A. baumannii for ID consultants. Differences in priorities regarding organisms, infection control practices, and educational priorities were visualized between ID/clinical microbiologists and ICU/anesthesiologists. Overall, both agree on concerns on resistant Gram-negative organisms. Need of team working is required to address best care for ICU subjects with severe infections.
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The study was performed as part of an Observership Grant (Vandana KE) from the European Society of Clinical Microbiology and Infectious Diseases, Basel, Switzerland. We appreciate comments in the design from Nieves Larrosa, Barcelona, Spain. The study was funded in part by Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. We thank the study group investigators for their valuable support.
The study was funded in part by Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain and Observership Programme from ESCMID, Basel, Switzerland.
Conflicts of interest
Dr. Rello served in the speaker’s bureau or consultant for Pfizer, Anchoagen, ROCHE. The remaining authors have no conflicts of interest to declare.
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Electronic supplementary material
Appendix 1. TOTEM Study Investigators
Argentina: Luna CM, Reina R; Bulgaria: Dobrevska R; China: Deng H, Leiqing L, Liu L, 温, 沈延飞, LX, Wang D, Yuetian Y, Zhang G, Zh Zhang, Zheng C, YW, ZRYHC; Colombia: Del Rio G; Dominican Republic: Rojas JN; Ethiopia: Amare D. France: Alfandri S, Argemi X, Kernies S, Lesprit P: Greece: Arvanitik K, Papanikolaou M, Tsigou E, Soultati I, Platsouka E, Katsiari M, Nikolaou C, Tsiodras S; Italy: Antonelli M, Cascio A, Dellamonica J, DiPascale G, Garofalo E, Girardis M, Leone D; India: Vandana KE, Kaniyarakkal V, Munim F, Nath S, Patil S, Suchitra U, Israel: Yahav D; Kenya: Misango DO; Kosovo:Gecaj-Gashi A; Kuwait: Rotimi V; Mexico: Aguilar D, Araujo-Melendez J, Franco-Zendejas R, Lagunes L, Lemus J, Perales Martinez DE, Rivera Chavez M; Netherlands: Schouten J; Oman: Khamis F; Pakistan: Nizamuddin S, Portugal: Santos L, Santos-Ribeiro E; South Africa: Alekar S, Baker D, Ballot D, Black V, Bhamjee S, Brannigan L, Hunt IA, Kotze J, Lowman W, Levy B, Mer M, Morar R,Michell W, Nana T, Pahad H, Tsai M, Schleicher GK, Shaddock E, Shoul E, Smith C, Richards GA, Van der Merwe L, Welkovics N; Spain: Borges M, Diaz E, J Garnacho-Montero, Maseda E, Mañez R, Rello J, Samso E, Serrano R, Sole-Violan J, Vidaur L, Zaragoza R; Thailand: Wongsurakiat P; Turkey: Abravci N, Akbudak I, Akkoyunlu Y, Altındiş M, Aydin DÇelebi G, Emel A, Alp E, Erdem H, Gulden E, Guner R, Kızmaz Y, Yalçin A, Kepenek E, Sener A, Tekin R, Tulek N, Ulu, Unuvar G; Romania: Miftode E; United Kingdom: Buckley J, Conway-Morris A, Dunn M, Hall A,Hobrok M, Felton T, Fletcher S, Marshall B, McConnell H, McKee R, McAuley D, McFie C, Morton B, Naisbitt J, Rooney K, Szakmany T, Yates B, Zochios V; USA: Richard G. Wunderink; Venezuela: Von der Osten J
Appendix 2- Steering Committee members
Jordi Rello, Spain (Chair); Joana Alves, Portugal; Leonel Lagunes, Mexico; Nieves Larrosa, Spain; Mervyn Mer, South Africa; Emine Alp, Turkey; Zhongheng Zhang, China.
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Rello, J., Kalwaje Eshwara, V., Conway-Morris, A. et al. Perceived differences between intensivists and infectious diseases consultants facing antimicrobial resistance: a global cross-sectional survey. Eur J Clin Microbiol Infect Dis 38, 1235–1240 (2019). https://doi.org/10.1007/s10096-019-03530-1
- Multidrug-resistant bacteria
- Infection control
- Intensive care