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Clinical characteristics of infections caused by Mycoplasma pneumoniae P1 genotypes in children

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Abstract

Mycoplasma pneumoniae (M. pneumoniae) isolates can be classified into two major genetic groups, P1 type 1 (MP1) and P1 type 2 (MP2), based on the DNA sequence of the P1 adhesion protein gene. The aim of our study was to determine if M. pneumoniae P1 genotype is associated with disease manifestation and severity of acute M. pneumoniae infection. We compared epidemiological and clinical data of children infected with either MP1 or MP2. In addition, we separately analysed data of patients presenting with individual manifestations of M. pneumoniae infection. Data of 356 patients infected with MP1 were compared with those of 126 patients infected with MP2. MP2-infected children presented with higher median baseline C-reactive protein levels and were admitted to the hospital more often. The distribution of P1 genotype varied among groups of patients with different manifestations of M. pneumoniae infection. MP2 was more common than MP1 among patients with neurological and cardiovascular manifestations, whereas MP1 was more prevalent in other manifestations. The results from our large cohort indicate that the two P1 subtypes may have different pathogenic potential and that infections with MP2 strains could be more virulent than those with MP1 strains.

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Authors and Affiliations

  1. Unit for Pulmonary Diseases, University Children’s Hospital, University Medical Centre, Bohoričeva 20, 1000, Ljubljana, Slovenia

    Jasna Rodman Berlot, Uroš Krivec & Marina Praprotnik

  2. Department of Infectious Diseases, University Medical Centre, Japljeva 2, 1000, Ljubljana, Slovenia

    Tatjana Mrvič

  3. Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000, Ljubljana, Slovenia

    Rok Kogoj & Darja Keše

Authors
  1. Jasna Rodman Berlot
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  2. Uroš Krivec
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  3. Marina Praprotnik
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  4. Tatjana Mrvič
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  5. Rok Kogoj
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  6. Darja Keše
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Corresponding authors

Correspondence to Jasna Rodman Berlot or Darja Keše.

Ethics declarations

The authors declare that ethical approval was not required. The study was performed only by using remnants of specimens that had initially been collected for diagnostic purposes. All samples from patients included in the study were rendered anonymous. The patients were registered with an encrypted number code. Therefore, individuals could not be matched with their samples and their epidemiological and clinical data. The study was conducted according to the principles expressed in the Declaration of Helsinki, the Oviedo Convention on Human Rights and Biomedicine and the Slovene Code of Medical Deontology. Since no additional samples or data were collected, the study was deemed to be low risk and the need for additional ethical permission from the National Medical Ethics Committee was waived.

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The authors declare that they have no conflict of interest.

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Rodman Berlot, J., Krivec, U., Praprotnik, M. et al. Clinical characteristics of infections caused by Mycoplasma pneumoniae P1 genotypes in children. Eur J Clin Microbiol Infect Dis 37, 1265–1272 (2018). https://doi.org/10.1007/s10096-018-3243-5

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  • DOI: https://doi.org/10.1007/s10096-018-3243-5

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