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Antiphospholipid antibodies proposed in the diagnosis of infective endocarditis

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European Journal of Clinical Microbiology & Infectious Diseases Aims and scope Submit manuscript

Abstract

Antiphospholipid antibodies (aPL) may occur alone or associated with other diseases. To evaluate aPL, tested as anticardiolipin antibodies (IgG aCL) in infective endocarditis (IE) diagnosis, we investigated their prevalence in a cohort of 651 patients with IE suspicion. aPL was significantly associated with definite IE versus IE-rejected patients. Their mean levels were significantly higher in patients with definite IE versus possible IE. When applied as Duke minor criterion, they were significantly more often positive, and at higher levels, in patients with definite IE than in patients with possible or rejected IE. aPL could be helpful in difficult cases of IE diagnosis.

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Acknowledgements

We thank Pr Jean-Louis Mege for his help in the critical review of the article.

Authorship

All authors had access to the data and contributed to the writing of the manuscript.

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Authors and Affiliations

  1. UM63, CNRS 7278, IRD 198, INSERM 1095 IHU - Méditerranée Infection, Aix-Marseille Université, 19-21 Boulevard Jean Moulin, 13385, Marseille Cedex 05, France

    C. Zaratzian, F. Gouriet, H. Tissot-Dupont, J.-P. Casalta, M. Million & D. Raoult

  2. Immunology Laboratory, Centre Hospitalier Universitaire, Hôpital de la Conception, AP-HM, Aix-Marseille University, Marseille, France

    N. Bardin

  3. Department of Cardiac Surgery, Centre Hospitalier Universitaire, Hôpital de La Timone, AP-HM, Aix-Marseille University, Marseille, France

    D. Grisoli

  4. Department of Cardiology, Centre Hospitalier Universitaire, Hôpital de La Timone, AP-HM, Aix-Marseille University, Marseille, France

    G. Habib

Authors
  1. C. Zaratzian
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  2. F. Gouriet
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  3. H. Tissot-Dupont
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  4. J.-P. Casalta
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  5. M. Million
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  6. N. Bardin
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  7. D. Grisoli
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  8. G. Habib
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  9. D. Raoult
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Corresponding author

Correspondence to D. Raoult.

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Each patient provided written consent.

Ethical approval

The study was approved by the local ethics committee (number 12-016).

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Cite this article

Zaratzian, C., Gouriet, F., Tissot-Dupont, H. et al. Antiphospholipid antibodies proposed in the diagnosis of infective endocarditis. Eur J Clin Microbiol Infect Dis 36, 1159–1162 (2017). https://doi.org/10.1007/s10096-017-2903-1

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  • DOI: https://doi.org/10.1007/s10096-017-2903-1

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