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Longitudinal study of a cohort of MSA-C patients in South Italy: survival and clinical features

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Abstract

Sixty-six patients with possible or probable MSA (multiple system atrophy) cerebellar type, personally observed between 2006 and 2018 were retrospectively reviewed. The time point of data collection was January 1, 2019. Forty-nine patients lost independent walking after a median time of 5 years (95% C. I. 4–6). Thirty-two patients were confined to wheelchair after a median time of 7 years (95% C. I. 7–8). Twenty-seven patients were deceased after a median time of 9 years (95% C. I. 8–10). A later onset predicted an earlier loss of independent walking (HR 1.07; 95% C.I. 1.03–1.11; p = 0.001). Higher UMSARS score predicted shorter time to loss of independent walking (HR 1.04; 95% C.I. 1.02–1.06; p = 0.001) and to wheelchair (HR 1.03; 95% C.I. 1.01–1.06; p = 0.021). No predictor of time to death was found.

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Author notes

  1. Maria Lieto, Alessandro Roca and Dario Bruzzese contributed equally to this work.

Authors and Affiliations

  1. Department of Neuroscience, Reproductive and Odontostomatological Sciences, Federico II University, Naples, Italy

    Maria Lieto, Alessandro Roca, Antonella Antenora, Girolamo Alfieri, Francesco Saccà, Marta Bellofatto, Leonilda Bilo, Stefano Barbato, Giuseppe De Michele & Alessandro Filla

  2. Department of Public Health, Federico II University, Naples, Italy

    Dario Bruzzese

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  1. Maria Lieto
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Correspondence to Alessandro Filla.

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The study protocol was approved by local Ethics Committee of the Federico II University in Naples.

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Lieto, M., Roca, A., Bruzzese, D. et al. Longitudinal study of a cohort of MSA-C patients in South Italy: survival and clinical features. Neurol Sci 40, 2105–2109 (2019). https://doi.org/10.1007/s10072-019-03948-7

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  • DOI: https://doi.org/10.1007/s10072-019-03948-7

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