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Altered white matter microstructure in patients with post-stroke depression detected by diffusion kurtosis imaging

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Abstract

The aim of our study is to determine the pathological changes of white matter microstructure in patients with early post-stroke depression (PSD), and to investigate the association between white matter integrity examined by diffusion kurtosis imaging (DKI) and early PSD. Thirty-eight patients with acute cerebral infarction were selected, including 17 patients with depression (PSD group), and 21 patients without depression (N-PSD group). In addition, 20 normal healthy controls (NORM group) were selected. All were taken DKI scans. The white matter of the frontal lobe, temporal lobe, parietal lobe, occipital lobe, anterior limb of internal capsule, and posterior limb of internal capsule, in addition to the genu of corpus callosum and splenium of corpus callosum was selected as a region of interest (ROI). Selected parameters include fractional anisotropy (FA) and mean kurtosis (MK). Compared with N-PSD group and NORM group, FA value of the left frontal lobe and MK value of the bilateral frontal lobe, bilateral temporal lobe, and genu of corpus callosum in PSD group were decreased (P < 0.05). Our results indicated that the early PSD patients had white matter microstructure abnormalities in the frontal lobe, temporal lobe, and genu of corpus callosum. DKI provides a comprehensive brain imaging reference for detecting early microstructural damage of white matter in PSD patients, which can be used as an imaging biomarker to detect early PSD and its progression potentially.

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Funding

This study was supported by Doctor Wenzhen Duan of Johns Hopkins University School of Medicine.

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Author notes

  1. Xue-Yong Shen and Ze-Xin Fan contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, The Second Hospital Affiliated to Shanxi Medical University, Taiyuan, 030001, Shanxi, People’s Republic of China

    Xue-Yong Shen, Ze-Xin Fan & Li Wang

  2. Department of Medical Imaging, The Second Hospital Affiliated to Shanxi Medical University, Taiyuan, 030001, Shanxi, People’s Republic of China

    Sha Cui & Jin-Liang Niu

Authors
  1. Xue-Yong Shen
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  2. Ze-Xin Fan
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  3. Li Wang
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  4. Sha Cui
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  5. Jin-Liang Niu
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Correspondence to Li Wang.

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Shen, XY., Fan, ZX., Wang, L. et al. Altered white matter microstructure in patients with post-stroke depression detected by diffusion kurtosis imaging. Neurol Sci 40, 2097–2103 (2019). https://doi.org/10.1007/s10072-019-03947-8

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  • DOI: https://doi.org/10.1007/s10072-019-03947-8

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