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Vis-à-vis: a focus on genetic features of cerebral cavernous malformations and brain arteriovenous malformations pathogenesis

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Abstract

Cerebrovascular malformations include a wide range of blood vessel disorders affecting brain vasculature. Neuroimaging differential diagnosis can result unspecific due to similar phenotypes of lesions and their deep localization. Next-generation sequencing (NGS) platforms simultaneously analyze several hundreds of genes and can be applied for molecular distinction of different phenotypes within the same disorder’s macro-area. We discuss about the main criticisms regarding molecular bases of cerebral cavernous malformations (CCM) and brain arteriovenous malformations (AVM), highlighting both common pathogenic aspects and genetic differences leading to lesion development. Many recent studies performed on human CCM and AVM tissues aim to detect genetic markers to better understand molecular bases and pathogenic mechanism, particularly for sporadic cases. Several genes involved in angiogenesis show different expression patterns between CCM and AVM, and these could represent a valid starting point to project a NGS panel to apply for differential cerebrovascular malformation diagnosis.

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Authors and Affiliations

  1. Department of Biomedical and Dental Science and Morphological and Functional Images, University of Messina, Consolare Valeria street 1, 98125, Messina, Italy

    Concetta Scimone, Luigi Donato, Concetta Alafaci, Rosalia D’Angelo & Antonina Sidoti

  2. Department of Vanguard Medicine and Therapies, Biomolecular Strategies and Neuroscience, I.E.ME.S.T, Michele Miraglia Street 20, 90139, Palermo, Italy

    Concetta Scimone, Luigi Donato & Antonina Sidoti

  3. IRCSS Centro Neurolesi “Bonino-Pulejo”, c.da Casazza, Messina, Italy

    Silvia Marino

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  1. Concetta Scimone
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  2. Luigi Donato
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Correspondence to Rosalia D’Angelo.

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Scimone, C., Donato, L., Marino, S. et al. Vis-à-vis: a focus on genetic features of cerebral cavernous malformations and brain arteriovenous malformations pathogenesis. Neurol Sci 40, 243–251 (2019). https://doi.org/10.1007/s10072-018-3674-x

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