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Chronic obstructive pulmonary disease may complicate Alzheimer’s disease: a comorbidity problem

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Abstract

Background and aim

Chronic obstructive pulmonary disease (COPD) may be associated with worsening of cognitive performance. We studied patients with Alzheimer’s disease (AD) with and without COPD, and we analyzed, in a retrospective way, clinical and neuropsychological variables to verify if COPD plays a pejorative role on cognitive or functional autonomy in patients with dementia.

Methods

We enrolled 23 adult patients (AD-COPD) with probable AD and COPD and 23 with AD only (AD-only); they were matched for sex, age, educational level, and Mini Mental State Examination (MMSE) at the disease onset. Global cognitive status was estimated using MMSE at the first assessment and after 24 months. Memory, executive functions, praxia, and language were the other cognitive domains analyzed. The two groups were also compared for the presence of behavioral disorders (anxiety, depression).

Results

AD-COPD had worse results in executive functions screening than AD-only; no significant differences were found comparing other cognitive domains; moreover, there was no significant difference between the two groups considering the decrease in MMSE scores. AD-COPD also showed a higher presence of depression.

Discussion

COPD is known to be associated with the development of cognitive deficits, in particular, regarding for executive functions and attention, memory and logical reasoning. In this context, MMSE has a low diagnostic accuracy to underline effective cognitive impairment in AD-COPD. Our study shows a higher frequency of frontal deficits and behavioral disturbances in patients with AD and COPD than patients with AD-only. COPD could complicate the management of AD patients, thus necessitating a closer and multidisciplinary monitoring.

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References

  1. Bunn F, Burn AM, Robinson L, Poole M, Rait G, Brayne C, Schoeman J, Norton S, Goodman C (2017) Healthcare organisation and delivery for people with dementia and comorbidity: a qualitative study exploring the views of patients, carers and professionals. BMJ Open 7(1):e013067

    Article  PubMed  PubMed Central  Google Scholar 

  2. Karlawish J, Jack CR Jr, Rocca WA, Snyder HM, Carrillo MC (2017) Alzheimer’s disease: the next frontier-special report 2017. Alzheimers Dement 13(4):374–380

    Article  PubMed  Google Scholar 

  3. Winblad B, Amouyel P, Andrieu S, Ballard C, Brayne C, Brodaty H, Cedazo-Minguez A, Dubois B, Edvardsson D, Feldman H, Fratiglioni L, Frisoni GB, Gauthier S, Georges J, Graff C, Iqbal K, Jessen F, Johansson G, Jönsson L, Kivipelto M, Knapp M, Mangialasche F, Melis R, Nordberg A, Rikkert MO, Qiu C, Sakmar TP, Scheltens P, Schneider LS, Sperling R, Tjernberg LO, Waldemar G, Wimo A, Zetterberg H (2016) Defeating Alzheimer’s disease and other dementias: a priority for European science and society. Lancet Neurol 15(5):455–532

    Article  PubMed  Google Scholar 

  4. Rabe KF, Watz H (2017) Chronic obstructive pulmonary disease. Lancet 389(10082):1931–1940

    Article  PubMed  Google Scholar 

  5. GBD 2015 Mortality and Causes of Death Collaborators (2016) Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 388:1459–544

  6. Landis SH, Muellerova H, Mannino DM, Menezes AM, Han MK, van der Molen T, Ichinose M, Aisanov Z, Oh YM, Davis KJ (2014) Continuing to confront COPD international patient survey: methods, COPD prevalence, and disease burden in 2012-2013. Int J Chron Obstruct Pulmon Dis 9:597–611

    PubMed  PubMed Central  Google Scholar 

  7. Vogelmeier CF, Criner GJ, Martinez FJ, Anzueto A, Barnes PJ, Bourbeau J, Celli BR, Chen R, Decramer M, Fabbri LM, Frith P, Halpin DM, López Varela MV, Nishimura M, Roche N, Rodriguez-Roisin R, Sin DD, Singh D, Stockley R, Vestbo J, Wedzicha JA, Agustí A (2017) Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. GOLD executive summary. Am J Respir Crit Care Med 195(5):557–582

    Article  PubMed  CAS  Google Scholar 

  8. Vestbo J, Hurd SS, Agustí AG, Jones PW, Vogelmeier C, Anzueto A, Barnes PJ, Fabbri LM, Martinez FJ, Nishimura M, Stockley RA, Sin DD, Rodriguez-Roisin R (2013) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 187(4):347–365

    Article  PubMed  CAS  Google Scholar 

  9. Grant I, Heaton RK, McSweeny AJ, Adams KM, Timms RM (1982) Neuropsychologic findings in hypoxemic chronic obstructive pulmonary disease. Arch Intern Med 142(8):1470–1476

    Article  PubMed  CAS  Google Scholar 

  10. Hung WW, Wisnivesky JP, Siu AL, Ross JS (2009) Cognitive decline among patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 180(2):134–137

    Article  PubMed  Google Scholar 

  11. Dodd JW, Getov SV, Jones PW (2010) Cognitive function in COPD. Eur Respir J 35(4):913–922

    Article  PubMed  CAS  Google Scholar 

  12. Schou L, Østergaard B, Rasmussen LS, Rydahl-Hansen S, Phanareth K (2012) Cognitive dysfunction in patients with chronic obstructive pulmonary disease—a systematic review. Respir Med 106(8):1071–1081

    Article  PubMed  Google Scholar 

  13. Villeneuve S, Pepin V, Rahayel S, Bertrand JA, de Lorimier M, Rizk A, Desjardins C, Parenteau S, Beaucage F, Joncas S, Monchi O, Gagnon JF (2012) Mild cognitive impairment in moderate to severe COPD: a preliminary study. Chest 142(6):1516–1523

    Article  PubMed  Google Scholar 

  14. Singh B, Mielke MM, Parsaik AK, Cha RH, Roberts RO, Scanlon PD, Geda YE, Christianson TJ, Pankratz VS, Petersen RC (2014) A prospective study of chronic obstructive pulmonary disease and the risk for mild cognitive impairment. JAMA Neurol 71(5):581–588

    Article  PubMed  PubMed Central  Google Scholar 

  15. Yohannes AM, Chen W, Moga AM, Leroi I, Connolly MJ (2017) Cognitive impairment in chronic obstructive pulmonary disease and chronic heart failure: a systematic review and meta-analysis of observational studies. J Am Med Dir Assoc 18(5):451.e1–451.e11

    Article  Google Scholar 

  16. Liao KM, Ho CH, Ko SC, Li CY (2015) Increased risk of dementia in patients with chronic obstructive pulmonary disease. Medicine (Baltimore) 94(23):e930

    Article  Google Scholar 

  17. Incalzi RA, Corsonello A, Pedone C, Corica F, Carbonin P, Bernabei R, GIFA Investigators (2005) Construct validity of activities of daily living scale: a clue to distinguish the disabling effects of COPD and congestive heart failure. Chest 127:830–838

    Article  PubMed  Google Scholar 

  18. Chang SS, Chen S, McAvay GJ, Tinetti ME (2012) Effect of coexisting chronic obstructive pulmonary disease and cognitive impairment on health outcomes in older adults. J Am Geriatr Soc 60(10):1839–1846

    Article  PubMed  PubMed Central  Google Scholar 

  19. Dodd JW, Charlton RA, van den Broek MD, Jones PW (2013) Cognitive dysfunction in patients hospitalized with acute exacerbation of COPD. Chest 144(1):119–127

    Article  PubMed  Google Scholar 

  20. Fix AJ, Daughton D, Kass I, Bell CW, Golden CJ (1985) Cognitive functioning and survival among patients with chronic obstructive pulmonary disease. Int J Neurosci 27(1–2):13–17

    Article  PubMed  CAS  Google Scholar 

  21. Salık Y, Ozalevli S, Cımrın AH (2007) Cognitive function and its effects on the quality of life status in the patients with chronic obstructive pulmonary disease (COPD). Arch Gerontol Geriatr 45(3):273–280

    Article  PubMed  Google Scholar 

  22. Baird C, Lovell J, Johnson M, Shiell K, Ibrahim JE (2017) The impact of cognitive impairment on self-management in chronic obstructive pulmonary disease: a systematic review. Respir Med 129:130–139

    Article  PubMed  Google Scholar 

  23. Maurer J, Rebbapragada V, Borson S, Goldstein R, Kunik ME, Yohannes AM, Hanania NA, ACCP workshop panel on anxiety and depression in COPD (2008) Anxiety and depression in COPD: current understanding, unanswered questions, and research needs. Chest 134(4 Suppl):43S–56S

    Article  PubMed  PubMed Central  Google Scholar 

  24. Pumar MI, Gray CR, Walsh JR, Yang IA, Rolls TA, Ward DL (2014) Anxiety and depression—important psychological comorbidities of COPD. J Thorac Dis 6(11):1615–1631

    PubMed  PubMed Central  Google Scholar 

  25. Cluley S, Cochrane GM (2001) Psychological disorder in asthma is associated with poor control and poor adherence to inhaled steroids. Respir Med 95:37–39

    Article  PubMed  CAS  Google Scholar 

  26. McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH et al (2011) The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7(3):263–269

    Article  PubMed  PubMed Central  Google Scholar 

  27. Folstein MF, Folstein SE, McHugh PR (1975) “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12(3):189–198

    Article  PubMed  CAS  Google Scholar 

  28. Rey A (1958) Mémorisation d’une series de 15 mots en 5 répetitions. In: Rey A (ed) L’examen clinique en psychologie. Presses. Universitaires de France, Paris

    Google Scholar 

  29. Gainotti G, Miceli G, Caltagirone C (1977) Constructional apraxia in left brain damaged patients: a planning disorders? Cortex 13:109–118

    Article  PubMed  CAS  Google Scholar 

  30. Borkowsky JG, Benton AL, Spreen O (1967) Word fluency and brain damage. Neuropsychologia. 5(2):135-140 https://doi.org/10.1016/0028-3932(67)90015-2

  31. Dubois B, Slachevsky A, Litvan I, Pillon B (2000) The FAB. A frontal assessment battery at bedside. Neurology 55:1621–1626

    Article  PubMed  CAS  Google Scholar 

  32. Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56–62

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  33. Cleutjens FA, Janssen DJ, Ponds RW, Dijkstra JB, Wouters EF (2014) COgnitive-pulmonary disease. Biomed Res Int 2014:697825

    Article  PubMed  PubMed Central  Google Scholar 

  34. Ouellette DR, Lavoie KL (2017) Recognition, diagnosis, and treatment of cognitive and psychiatric disorders in patients with COPD. Int J Chron Obstruct Pulmon Dis 12:639–650

    Article  PubMed  PubMed Central  Google Scholar 

  35. Antonelli Incalzi R, Marra C, Giordano A, Calcagni ML, Cappa A, Basso S, Pagliari G, Fuso L (2003) Cognitive impairment in chronic obstructive pulmonary disease--a neuropsychological and spect study. J Neurol 250(3):325–332

    Article  PubMed  Google Scholar 

  36. Parekh PI, Blumenthal JA, Babyak MA, LaCaille R, Rowe S, Dancel L, Carney RM, Davis RD, Palmer S, INSPIRE Investigators (2005) Gas exchange and exercise capacity affect neurocognitive performance in patients with lung disease. Psychosom Med 67(3):425–432

    Article  PubMed  Google Scholar 

  37. Zhang H, Wang X, Lin J, Sun Y, Huang Y, Yang T, Zheng S, Fan M, Zhang J (2012) Grey and white matter abnormalities in chronic obstructive pulmonary disease: a case–control study. BMJ Open 2(2):e000844

    Article  PubMed  PubMed Central  Google Scholar 

  38. Ortapamuk H, Naldoken S (2006) Brain perfusion abnormalities in chronic obstructive pulmonary disease: comparison with cognitive impairment. Ann Nucl Med 20(2):99–106

    Article  PubMed  Google Scholar 

  39. Li J, Fei GH (2013) The unique alterations of hippocampus and cognitive impairment in chronic obstructive pulmonary disease. Respir Res 14:140

    Article  PubMed  PubMed Central  Google Scholar 

  40. Nday CM, Eleftheriadou D, Jackson G (2017) Shared pathological pathways of Alzheimer’s disease with specific comorbidities: current perspectives and interventions. J Neurochem 144(4):360–389. https://doi.org/10.1111/jnc.14256

  41. Crews WD, Jefferson AL, Bolduc T, Elliott JB, Ferro NM, Broshek DK, Barth JT, Robbins MK (2001) Neuropsychological dysfunction in patients suffering from end-stage chronic obstructive pulmonary disease. Arch Clin Neuropsychol 16(7):643–652

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  42. Andreaou G, Vlachos F, Makanikas K (2014) Effects of chronic obstructive pulmonary disease and obstructive sleep apnea on cognitive functions: evidence for a common nature. Sleep Disord 2014:768210

    Google Scholar 

  43. De Carolis A, Giubilei F, Caselli G, Casolla B, Cavallari M, Vanacore N, Leonori R, Scrocchia I, Fersini A, Quercia A, Orzi F (2011) Chronic obstructive pulmonary disease is associated with altered neuropsychological performance in young adults. Dement Geriatr Cogn Disord Extra 1:402–408

    Article  Google Scholar 

  44. Kozora E, Filley CM, Julian LJ, Cullum CM (1999) Cognitive functioning in patients with chronic obstructive pulmonary disease and mild hypoxemia compared with patients with mild Alzheimer disease and normal controls. Neuropsychiatry Neuropsychol Behav Neurol 12(3):178e83

    Google Scholar 

  45. Antonelli-Incalzi R, Corsonello A, Trojano L, Pedone C, Acanfora D, Spada A, Izzo O, Rengo F (2007) Screening of cognitive impairment in chronic obstructive pulmonary disease. Dement Geriatr Cogn Disord 23(4):264–270

    Article  PubMed  Google Scholar 

  46. Yohannes AM, Baldwin RC, Connolly MJ (2000) Depression and anxiety in elderly outpatients with chronic obstructive pulmonary disease: prevalence, and validation of the BASDEC screening questionnaire. Int J Geriatr Psychiatry 15:1090–1096

    Article  PubMed  CAS  Google Scholar 

  47. Chi S, Yu JT, Tan MS, Tan L (2014) Depression in Alzheimer’s disease: epidemiology, mechanisms, and management. J Alzheimers Dis 42(3):739–755

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Translational Medicine, Section of Neurology, University of Eastern Piedmont, Novara, Italy

    Giacomo Tondo, Fabiola De Marchi, Emanuela Terazzi, Paolo Prandi, Marta Sacchetti, Cristoforo Comi & Roberto Cantello

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  1. Giacomo Tondo
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  2. Fabiola De Marchi
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Correspondence to Fabiola De Marchi.

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Tondo, G., De Marchi, F., Terazzi, E. et al. Chronic obstructive pulmonary disease may complicate Alzheimer’s disease: a comorbidity problem. Neurol Sci 39, 1585–1589 (2018). https://doi.org/10.1007/s10072-018-3470-7

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  • DOI: https://doi.org/10.1007/s10072-018-3470-7

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