The difference in visuomotor feedback velocity control during spiral drawing between Parkinson’s disease and essential tremor

  • Kai-Hsiang Chen
  • Po-Chieh Lin
  • Bing-Shiang Yang
  • Yu-Jung Chen
Original Article

Abstract

In a spiral task, the accuracy of the spiral trajectory, which is affected by tracing or tracking ability, differs between patients with Parkinson’s disease (PD) and essential tremor (ET). However, not many studies have analyzed velocity differences between the groups during this task. This study aimed to examine differences between the groups related to this characteristic using a tablet. Fourteen PD, 12 ET, and 12 control group participants performed two tasks: tracing a given spiral (T1) and following a guiding point (T2). A digitized tablet was used to record movements and trajectory. Effects of direct visual feedback on intergroup and intragroup velocity were measured. Although PD patients had a significantly lower T1 velocity than the control group (p < 0.05), they could match the velocity of the guiding point (3.0 cm/s) in T2. There was no significant difference in the average T1 velocity between ET and the control groups (p = 0.26); however, the T2 velocity of ET patients was significantly higher than the control group (p < 0.05). They were also unable to adjust the velocity to match the guiding point, indicating that ET patients have a poorer ability to follow dynamic guidance. When both groups of patients have similar action tremor severity, their ability to follow dynamic guidance was still significantly different. Our study combined visual feedback with spiral drawing and demonstrated differences in the following-velocity distribution in PD and ET. This method may be used to distinguish the tremor presentation of both diseases, and thus, provide accurate diagnosis.

Keywords

Parkinson’s disease Essential tremor Spiral drawing Visual feedback 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

References

  1. 1.
    Jain S, Lo SE, Louis ED (2006) Common misdiagnosis of a common neurological disorder: how are we misdiagnosing essential tremor? Arch Neurol 63:1100–1104CrossRefPubMedGoogle Scholar
  2. 2.
    Thenganatt MA, Jankovic J (2016) The relationship between essential tremor and Parkinson’s disease. Parkinsonism Relat Disord 22:S162–S1S5CrossRefPubMedGoogle Scholar
  3. 3.
    Algarni M, Fasano A (2018) The overlap between Essential tremor and Parkinson disease. Parkinsonism Relat Disord 46:S101–S1S4CrossRefPubMedGoogle Scholar
  4. 4.
    Chen K-H, Lin P-C, Chen Y-J, Yang B-S, Lin C-H (2016) Development of method for quantifying essential tremor using a small optical device. J Neurosci Methods 266:78–83CrossRefPubMedGoogle Scholar
  5. 5.
    Sisti JA, Christophe B, Seville AR, Garton AL, Gupta VP, Bandin AJ, Yu O, Pullman SL (2017) Computerized spiral analysis using the iPad. J Neurosci Methods 275:50–54CrossRefPubMedGoogle Scholar
  6. 6.
    Sharma S, Pandey S (2016) Approach to a tremor patient. Ann Indian Acad Neurol 19:433CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Yu N-Y, Van Gemmert AW, Chang S-H (2017) Characterization of graphomotor functions in individuals with Parkinson’s disease and essential tremor. Behav Res Methods 49:913–922CrossRefPubMedGoogle Scholar
  8. 8.
    Wei C, Xiao Z (2016) Review on clinical update of essential tremor. Neurol Sci 37(4):495–502CrossRefGoogle Scholar
  9. 9.
    Liu X, Miall RC, Aziz TZ, Palace JA, Haggard PN, Stein JF (1997) Analysis of action tremor and impaired control of movement velocity in multiple sclerosis during visually guided wrist-tracking tasks. Mov Disord 12:992–999CrossRefPubMedGoogle Scholar
  10. 10.
    Liu X, Tubbesing SA, Aziz TZ, Miall RC, Stein JF (1999) Effects of visual feedback on manual tracking and action tremor in Parkinson’s disease. Exp Brain Res 129:477–481CrossRefPubMedGoogle Scholar
  11. 11.
    Schwartz M, Groshar D, Inzelberg R, Hocherman S (2004) Dopamine-transporter imaging and visuo-motor testing in essential tremor, practical possibilities for detection of early stage Parkinson’s disease. Parkinsonism Relat Disord 10:385–389CrossRefPubMedGoogle Scholar
  12. 12.
    Schwartz M, Badarny S, Gofman S, Hocherman S (1999) Visuomotor performance in patients with essential tremor. Mov Disord 14:988–993CrossRefPubMedGoogle Scholar
  13. 13.
    Hocherman S, Giladi N (1998) Visuornotor control abnormalities in patients with unilateral parkinsonism. Neurology 50:1648–1654CrossRefPubMedGoogle Scholar
  14. 14.
    Lin P-C, Chen K-H, Yang B-S, Chen Y-J (2018) A digital assessment system for evaluating kinetic tremor in essential tremor and Parkinson’s disease. BMC Neurol 18:25CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Deuschl G, Bain P, Brin M (1998) Consensus statement of the movement disorder society on tremor. Mov Disord 13:2–23CrossRefPubMedGoogle Scholar
  16. 16.
    Daniel S, Lees A (1993) Parkinson’s Disease Society Brain Bank, London: overview and research. J Transm Suppl 39:165–172Google Scholar
  17. 17.
    Inzelberg R, Schechtman E, Hocherman S (2008) Visuo-motor coordination deficits and motor impairments in Parkinson’s disease. PLoS One 3:e3663CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    Kulkarni O, Lafaver K, Tarsy D (2013) The “floating door sign” in Parkinson’s disease. Parkinsonism Relat Disord 19:825–826CrossRefPubMedGoogle Scholar
  19. 19.
    Chen J, Ho S-L, Lee TM-C, Chang RS-K, Pang SY-Y, Li L (2016) Visuomotor control in patients with Parkinson’s disease. Neuropsychologia 80:102–114CrossRefPubMedGoogle Scholar
  20. 20.
    Rao AK, Gillman A, Louis ED (2011) Quantitative gait analysis in essential tremor reveals impairments that are maintained into advanced age. Gait Posture 34:65–70CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Farkas Z, Szirmai I, Kamondi A (2006) Impaired rhythm generation in essential tremor. Mov Disord 21:1196–1199CrossRefPubMedGoogle Scholar
  22. 22.
    Bareš M, Lungu OV, Husárová I, Gescheidt T (2010) Predictive motor timing performance dissociates between early diseases of the cerebellum and Parkinson’s disease. Cerebellum 9:124–135CrossRefPubMedGoogle Scholar
  23. 23.
    Coltz J, Johnson M, Ebner T (1999) Cerebellar Purkinje cell simple spike discharge encodes movement velocity in primates during visuomotor arm tracking. J Neurosci 19:1782–1803PubMedGoogle Scholar
  24. 24.
    Lehéricy S, Benali H, Van de Moortele P-F, Pélégrini-Issac M, Waechter T, Ugurbil K, Doyon J (2005) Distinct basal ganglia territories are engaged in early and advanced motor sequence learning. Proc Natl Acad Sci U S A 102:12566–12571CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Neurology, Hsinchu BranchNational Taiwan University HospitalHsinchu CityTaiwan
  2. 2.Department of Mechanical EngineeringNational Chiao Tung UniversityHsinchu CityTaiwan
  3. 3.Institute of Biomedical EngineeringNational Chiao Tung UniversityHsinchu CityTaiwan

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