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Relevance of sleep quality on caregiver burden in Parkinson’s disease

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Abstract

Parkinson’s disease (PD) is a neurodegenerative disorder which affects the quality of life of patient and their family. Sleep disorders appear in 80–90% of PD patients and have a great impact on the PD well-being. We examined the relationship of patients’ sleep quality and depression on burden, mood, quality of life, and quality of sleep of their caregivers. A multicenter, regional (Veneto), observational, cross-sectional study that included 55 patient-caregiver pairs was conducted. Patients were assessed using Parkinson’s Disease Sleep Scale (PDSS) and Epworth Sleepiness Scale (ESS) for sleep disorders, Beck Depression Inventory (BDI) as a measure of depression, and Parkinson’s Disease Questionnaire (PDQ-39) as a measure of quality of life. Caregivers were evaluated by the Caregiver Burden Inventory (CBI) a measure of burden, BDI, SF-36 Health Survey as measures of HRQoL, and Medical Outcomes Study-Sleep Scale (MOS-SS) for quality of sleep. CBI, HRQoL, MOS-SS, and BDI scores displayed no association with patients’ age, cognition (Mini Mental State Examination (MMSE) and Frontal Assessment Battery (FAB)), disease duration, and Hoehn and Yahr (H&Y), and UPDRS III scales whereas were significantly correlated with patients’ quality of sleep, depression, and quality life. CBI and HRQoL were also associated respectively with patients’ ESS and l-dopa daily dose. This study underscores the presence of a significant relationship between patient and caregiver quality of life. Interestingly, sleep quality and depression rather than motor disability best predicted caregivers’ well-being

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References

  1. Dickens CM, McGowan L, Percival C, Douglas J, Tomenson B, Cotter L, Heagerty A, Creed FH (2004) Lack of a close confidant, but not depression, predicts further cardiac events after myocardial infarction. Heart 90(5):518–522. https://doi.org/10.1136/hrt.2003.011668

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Gilhooly ML (1986) Senile dementia: factors associated with caregivers’ preference for institutional care. Br J Med Psychol 2(Pt 2):165–171

    Article  Google Scholar 

  3. Deimling GT, Poulshock SW (1985) The transition from family in-home care to institutional care. Focus on health and attitudinal issues as predisposing factors. Res Aging 7(4):563–576. https://doi.org/10.1177/0164027585007004004

    Article  CAS  PubMed  Google Scholar 

  4. Gilleard CJ (1987) Influence of emotional distress among supporters on the outcome of psychogeriatric day care. Br J Psychiatry 150(02):219–223. https://doi.org/10.1192/bjp.150.2.219

    Article  CAS  PubMed  Google Scholar 

  5. Martinez-Martin P, Forjaz MJ, Frades-Payo B et al (2007) Caregiver burden in Parkinson’s disease. Mov Disord 22(7):924–931. https://doi.org/10.1002/mds.21355

    Article  PubMed  Google Scholar 

  6. Edwards NE, Scheetz PS (2002) Predictors of burden for caregivers of patients with Parkinson’s disease. J Neurosci Nurs 34(4):184–190. https://doi.org/10.1097/01376517-200208000-00003

    Article  PubMed  Google Scholar 

  7. Schrag A, Hovris A, Morley D, Quinn N, Jahanshahi M (2006) Caregiver-burden in Parkinson’s disease is closely associated with psychiatric symptoms, falls, and disability. Parkinsonism Relat Disord 12(1):35–41. https://doi.org/10.1016/j.parkreldis.2005.06.011

    Article  PubMed  Google Scholar 

  8. Santos-Garcia D, de la Fuente-Fernandez R (2015) Factors contributing to caregivers’ stress and burden in Parkinson’s disease. Acta Neurol Scand 131(4):203–210. https://doi.org/10.1111/ane.12305

    Article  CAS  PubMed  Google Scholar 

  9. Parkinson J (1817) An essay on the shaking palsy. Sherwood, Neely, and Jones, London

    Google Scholar 

  10. Comella C (2007) Sleep disorders in Parkinson’s disease: an overview. Mov Disord 22(Suppl 17):S367–S373. https://doi.org/10.1002/mds.21682

    Article  PubMed  Google Scholar 

  11. Stocchi F, Barbato L, Nordera G, Berardelli A, Ruggieri S (1998) Sleep disorders in Parkinson’s disease. J Neurol 245(Suppl1):S15–S18. https://doi.org/10.1007/PL00007731

    Article  PubMed  Google Scholar 

  12. Askenasy JJM (1993) Sleep in Parkinson’s disease. Acta Neurol Scand 87(3):167–170

    Article  CAS  PubMed  Google Scholar 

  13. Naismith SL, Hickie IB, Lewis SJ (2010) The role of mild depression in sleep disturbance and quality of life in Parkinson’s disease. J Neuropsychiatry Clin Neurosci 22(4):384–389. https://doi.org/10.1176/jnp.2010.22.4.384

    Article  PubMed  Google Scholar 

  14. Gjerstad MD, Wentzel-Larsen T, Aarsland D, Larsen JP (2007) Insomnia in Parkinson’s disease: frequency and progression over time. J Neurol Neurosurg Psychiatry 78:476–479

    Article  CAS  PubMed  Google Scholar 

  15. Caap-Ahlgren M, Dehlin O (2001) Insomnia and depressive symptoms in patients with Parkinson’s disease—relationship to health-related quality of life. An interview study of patients living at home. Arch Gerontol Geriatr 32(1):23–33. https://doi.org/10.1016/S0167-4943(00)00087-X

    Article  CAS  PubMed  Google Scholar 

  16. Goldman JG, Stebbins GT, Leung V, Tilley BC, Goetz CG (2014) Relationships among cognitive impairment, sleep, and fatigue in Parkinson’s disease using the MDS-UPDRS. Parkinsonism and Related Disorders 20(11):1135–1139. https://doi.org/10.1016/j.parkreldis.2014.08.001

    Article  PubMed  PubMed Central  Google Scholar 

  17. Happe S, Berger K (2002) The association between caregiver burden and sleep disturbances in partners of patients with Parkinson’s disease. Age Ageing 31(5):349–354. https://doi.org/10.1093/ageing/31.5.349

    Article  PubMed  Google Scholar 

  18. Pal PK, Thennarasu K, Fleming J, Schulzer M, Brown T, Calne SM (2004) Nocturnal sleep disturbances and daytime dysfunction in patients with Parkinson’s disease and in their caregivers. Parkinsonism Relat Disord 10(3):157–168. https://doi.org/10.1016/j.parkreldis.2003.11.002

    Article  CAS  PubMed  Google Scholar 

  19. Chaudhuri KR, Pal S, Di Marco A, Whately-Smith C, Bridgman K, Mathew R, Pezzela FR, Forbes A, Hogl B, Trenkwalder C (2002) The Parkinson’s disease sleep scale: a new instrument for assessing sleep and nocturnal disability in Parkinson’s disease. J Neurol Neurosurg Psychiatry 73:629–635

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Johns MW (1991) A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 14(6):540–545. https://doi.org/10.1093/sleep/14.6.540

    Article  CAS  PubMed  Google Scholar 

  21. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J (1961) An inventory for measuring depression. Arch Gen Psychiatry 4(6):561–571. https://doi.org/10.1001/archpsyc.1961.01710120031004

    Article  CAS  PubMed  Google Scholar 

  22. Jenkinson C, Fitzpatrick R, Peto V, Greenhall R, Hyman N (1997) The Parkinson’s disease questionnaire (PDQ-39): development and validation of a Parkinson’s disease summary index score. Age Ageing 26:353–357

    Article  CAS  PubMed  Google Scholar 

  23. Novak M, Guest C (1989) Application of a multidimensional caregiver burden inventory. Gerontolist 29:798–803

    CAS  Google Scholar 

  24. Ware JE Jr, , Sherbourne CD. The Mos 36-item short-form health survey (SF-36) I Concectual framework and item selection. Med Care 1992; 30: 473–483, 6

    Article  PubMed  Google Scholar 

  25. Hays RD, Stewart AL (1992) Sleep measures. In: Stewart AL, Ware JE (eds) Measuring functioning and well-being: the Medical Outcomes Study approach. Duke University Press, Durham, pp 235–259

    Google Scholar 

  26. Carod-Artal FJ, Mesquita HM, Ziomkowski S, Martinez-Martin P (2013) Burden and health-related quality of life among caregivers of Brazilian Parkinson’s disease patients. Parkinsonism Relat Disord 19(11):943–948. https://doi.org/10.1016/j.parkreldis.2013.06.005

    Article  PubMed  Google Scholar 

  27. Roland KP, Jenkins ME, Johnson AM (2010) An exploration of the burden experienced by spousal caregivers of individuals with Parkinson’s disease. Mov Disord 25:189–193

    Article  PubMed  Google Scholar 

  28. Smith MC, Ellgring H, Oertel WH (1997) Sleep disturbances in Parkinson’s disease patients and spouses. J Am Geriatr Soc 45(2):194–199. https://doi.org/10.1111/j.1532-5415.1997.tb04506.x

    Article  CAS  PubMed  Google Scholar 

  29. Leroi I, Baker P, Kehoe P, Daniel E, Byrne EJ (2010) A pilot randomized controlled trial of sleep therapy in Parkinson’s disease: effect on patients and caregivers. Int J Geriatr Psychiatry 25(10):1073–1079. https://doi.org/10.1002/gps.2472

    Article  PubMed  Google Scholar 

  30. Fahn S, Elton R, Members of the UPDRS Development Committee (1987) In: Fahn S, Marsden CD, Calne DB, Goldstein M (eds) Recent developments in Parkinson’s disease, Vol 2. Florham Park. Macmillan Health Care Information:153–163, 293–304

  31. Folstein SE, Folstein MF, McHugh PR (1975) “MiniMental state”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12(3):189–198. https://doi.org/10.1016/0022-3956(75)90026-6

    Article  CAS  PubMed  Google Scholar 

  32. Dubois B, Slachevsky A, Litvan I, Pillon B (2000) The FAB: a frontal assessment battery at bedside. Neurology 55(11):1621–1626

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neurosciences, San Bortolo Hospital, Vicenza, Italy

    Luigi Bartolomei, Lucia Meligrana, Elena Sanson, Nicola Bonetto & Giacomo Maria Minicuci

  2. U.O. Neurologia, Ospedale San Bortolo, 36100, Vicenza, Italy

    Luigi Bartolomei

  3. Department of Economics, Ca’ Foscari University, Venice, Italy

    Andrea Pastore

  4. Psychology Unit, San Bortolo Hospital, Vicenza, Italy

    Lucia Meligrana & Elena Sanson

  5. Neurology Department, San Martino Hospital, Belluno, Italy

    Sandro Zambito Marsala

  6. Neurology Department, Cazzavillan Hospital, Arzignano, Italy

    Tiziana Mesiano

  7. Neurology Department, San Bassiano Hospital, Bassano, Italy

    Lorenzo Bragagnolo

  8. Parkinson and Movement Disorders Unit, Fondazione Ospedale San Camillo “I.R.C.C.S.”, Venice, Italy

    Angelo Antonini

  9. Department of Neurosciences (DNS), Padova University, Padova, Italy

    Angelo Antonini

Authors
  1. Luigi Bartolomei
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  2. Andrea Pastore
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  3. Lucia Meligrana
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  4. Elena Sanson
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  6. Giacomo Maria Minicuci
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  9. Lorenzo Bragagnolo
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Correspondence to Luigi Bartolomei.

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Research involving human participants

All procedures performed in this study were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Bartolomei, L., Pastore, A., Meligrana, L. et al. Relevance of sleep quality on caregiver burden in Parkinson’s disease. Neurol Sci 39, 835–839 (2018). https://doi.org/10.1007/s10072-018-3252-2

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  • DOI: https://doi.org/10.1007/s10072-018-3252-2

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