Neurological Sciences

, Volume 39, Issue 4, pp 805–807 | Cite as

Seizure as the unique clinical manifestation of cerebral metastases in a 27-year-old man with non-small cell lung cancer

  • Rui-Juan Lv
  • Pu Yin
  • Qun Wang
  • Xiao-Qiu Shao
Letter to the Editor

Dear editor,

Brain metastases (BM) occur in 20–40% of patients with non-small cell lung cancer (NSCLC) at some point during the disease course [1]. NSCLC is heterogeneous in terms of its histological subtypes and distinct driving oncogenes [2], which may affect the development of BM. Adenocarcinoma, identified through histology, has been reported to be associated with BM from NSCLC. Patients with BM from NSCLC often present with headaches, nausea and vomiting, seizures, and meningeal irritation. However, patients with BM from NSCLC who only present with seizures without any evidence of lung cancer are very rare. In this report, we describe a 27-year-old man with BM from NSCLC whose only presenting symptom was seizure.

A 27-year-old man presented to the emergency department during Chinese spring festival with a history of seizures that had been occurring for the previous 5 days. The seizures were described by the paramedics as well as by bystanders as a Jacksonian seizure affecting the...


Funding information

This work was supported by grants from the National Natural Science Foundation of China (No. 81301119), the Beijing Municipal Administration of Hospitals’ Youth Programme (No. QML20160504), the China Association Against Epilepsy-UCB Research Fund (No. CAAE-UCB2016008), and the National Key Technology Research and Development Program of the Ministry of Science and Technology of China (No. 2013BAI09B03).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


  1. 1.
    Mujoomdar A, Austin JH, Malhotra R, Powell CA, Pearson GD, Shiau MC, Raftopoulos H (2007) Clinical predictors of metastatic disease to the brain from non-small cell lung carcinoma: primary tumor size, cell type, and lymph node metastases. Radiology 242(3):882–888. CrossRefPubMedGoogle Scholar
  2. 2.
    Li T, Kung HJ, Mack PC, Gandara DR (2013) Genotyping and genomic profiling of non-small-cell lung cancer: implications for current and future therapies. J Clin Oncol Off J Am Soc Clin Oncol 31(8):1039–1049. CrossRefGoogle Scholar
  3. 3.
    Kesari S, Batchelor TT (2003) Leptomeningeal metastases. Neurol Clin 21(1):25–66. CrossRefPubMedGoogle Scholar
  4. 4.
    Dasgupta A, Sarkar D, Devi LG, Haldar S, Das D, Ghosh B, Dasgupta C, Basu S, Ghosh A, Majumdar A (2005) Primary neurological manifestations of lung cancer—a retrospective analysis of 8 patients. J Assoc Physicians India 53:208–212PubMedGoogle Scholar
  5. 5.
    Lee MH, Kong DS, Seol HJ, Nam DH, Lee JI (2013) Risk of seizure and its clinical implication in the patients with cerebral metastasis from lung cancer. Acta Neurochir 155(10):1833–1837. CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2017

Authors and Affiliations

  1. 1.Department of NeurologyBeijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological DiseasesDongcheng DistrictPeople’s Republic of China
  2. 2.Department of NeurologyBeijing Puren HospitalDongcheng DistrictPeople’s Republic of China

Personalised recommendations