Neurological Sciences

, Volume 39, Issue 4, pp 769–771 | Cite as

Transient lesion in splenium of the corpus callosum presenting as mild encephalopathy

  • Vasfiye Burcu Dogan
  • Eda Kilic Coban
  • Pinar Çelikkıran
  • Batuhan Kara
  • Aysun Soysal
Letter to the Editor

Dear Editor,

Acquired lesions in splenium of the corpus callosum (SCC) in magnetic resonance imaging (MRI) can be seen in several various disorders, including ischemia, demyelinating disorders, tumours and trauma [1]. It is reported with approximately 3% prevalence in a large number of patients by McLeod et al. The development of radiological technology and the increased accessibility of advanced MRI techniques such as diffusion-weighted MRI (DWI) have resulted in the detection of transient lesions in SCC in recent years. As those lesions have been reported in patients with mild encephalopathy/encephalitis, it is called as mild encephalopathy with reversible isolated SCC lesion (MERS) [2].

A 45-year-old female was admitted to the psychiatry department of the hospital 15 days prior by depressive mood, scepticism and decreased speech after a discussion with her husband. She was diagnosed as having psychotic depression and prescribed olanzapine and citalopram. Although she used the...


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Conflict of interest

The authors declare that they have no conflict of interest.


  1. 1.
    Garcia-Monco JC, Cortina IE, Ferreira E, Martínez A, Ruiz L, Cabrera A, Beldarrain MG (2011) Reversible splenial lesion syndrome (RESLES): what’s in a name? J Neuroimaging 21(2):1–14CrossRefGoogle Scholar
  2. 2.
    Cho JS, Ha SW, Han YS, Park SE, Hong KM, Han JH, Cho EK, Kim DE, Kim JG (2007 Mar) Mild encephalopathy with reversible lesion in the splenium of the corpus callosum and bilateral frontal white matter. J Clin Neurol 3(1):53–56CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Polster T, Hoppe M, Ebner A (2001) Transient lesion in the splenium of the corpus callosum: three further cases in epileptic patients and a pathophysiological hypothesis. J Neurol Neurosurg Psychiatry 70:459–463CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Takanashi J, Barkovich AJ, Shiihara T, Tada H, Kawatani M, Tsukahara H, Kikuchi M, Maeda M (2006) Widening spectrum of a reversible splenial lesion with transiently reduced diffusion. AJNR Am J Neuroradiol 27:836–838PubMedGoogle Scholar
  5. 5.
    Takanashi J, Maeda M, Hayashi M (2005) Neonate showing a reversible splenial lesion. Arch Neurol 62:1481–1482CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia S.r.l. 2017

Authors and Affiliations

  1. 1.Bakirkoy Prof. Dr. Mazhar Osman Psychiatry and Neurology Research and Training HospitalIstanbulTurkey
  2. 2.Bakirkoy Dr. Sadi Konuk Bakirkoy Research and Training HospitalIstanbulTurkey

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