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Screening for intermediate CGG alleles of FMR1 gene in male Iranian patients with Parkinsonism

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Abstract

Male carriers of an expansion of CGG alleles (with 55–200 CGG repeats) in the FMR1 gene are affected with Fragile X-associated tremor/ataxia syndrome (FXTAS). On the other hand, individuals with Parkinson’s disease (PD) or Parkinsonism spectrum disorders may have some clinical features that overlap with FXTAS. To investigate the possible association between PD and FMR1 expanded alleles, we screened a total of 154 male PD patients and 190 gender- and age-matched healthy control subjects from Iran. Eleven intermediate allele carriers (7.14 %) were detected among PD patients, compared with three carriers (1.57 %) among the controls (P = 0.01). No pre-mutation carriers were identified. Our results indicate that there is a potential association between FMR1 intermediate expanded alleles and PD.

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Acknowledgments

The authors honestly acknowledge all the participants for their cooperation. This work was supported by grants from the Immunology Research Center of Tabriz University of Medical Sciences, Tabriz, Iran.

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Authors and Affiliations

  1. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Atefeh Entezari & Sima Mansoori Derakhshan

  2. Department of Clinical Biochemistry, Division of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Atefeh Entezari, Mahmoud Shekari Khaniani & Sima Mansoori Derakhshan

  3. Genetics Research Center (GRC), University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

    Tayyeb Bahrami

  4. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Hossein Darvish

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  1. Atefeh Entezari
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  2. Mahmoud Shekari Khaniani
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Correspondence to Sima Mansoori Derakhshan.

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Entezari, A., Khaniani, M.S., Bahrami, T. et al. Screening for intermediate CGG alleles of FMR1 gene in male Iranian patients with Parkinsonism. Neurol Sci 38, 123–128 (2017). https://doi.org/10.1007/s10072-016-2723-6

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