Abstract
The purpose of this case report is to describe MR imaging and CT findings of a patient in whom the first clinical and neuroradiological manifestation of a metastatic lung adenocarcinoma was unilateral trigeminal neuropathy caused by a presumed metastasis involving cisternal and Meckel’s cave segments of ipsilateral trigeminal nerve. MR imaging and CT scan differential diagnosis of expansive lesions of the intracranial trigeminal nerve must include metastases. Physicians and neuroradiologists must be aware of metastases as an uncommon cause of trigeminal neuropathy, even as the presenting condition of cancer.
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Go JL, Kim PE, Zee C (2001) The trigeminal nerve. Semin Ultrasound, CT, MR 22:502–520
Woolfall P, Coulthard A (2001) Trigeminal nerve: anatomy and pathology. Br J Radiol 74:458–467
VandeVyer V, Lemmerling M, Van Hecke W et al (2007) MRI findings of the normal and diseased trigeminal nerve ganglion and branches: a pictorial review. JBR-BTR 90:272–277
Majoje CBLM, Aramideh M, Hulsmans FJ et al (1999) Correlation between electromyographic reflex and MR imaging examinations of the trigeminal nerve. AJNR Am J Neuroradiol 20:1119–1125
Majoje CBLM, Hulsmans FJ, Casteljins JA et al (1999) Primary nerve-sheath tumours of the trigeminal nerve: clinical and MRI findings. Neuroradiology 41:100–108
Stone JA, Cooper H, Castillo M et al (2001) Malignant schwannoma of the trigeminal nerve. AJNR Am J Neuroradiol 20:1119–1125
Motoori K, Hanazawa T, Yamakami I et al (2006) Intra- and extracranial solitary fibrous tumor of the trigeminal nerve: CT and MR imaging appearance. AJNR Am J Neuroradiol 31:280–281
Beschorner R, Mittelbronn M, Koerbel A et al (2006) Atypical teratoid-rhabdoid tumor spreading along the trigeminal nerve. Pediatr Neurosurg 42:258–263
Abdel Aziz KM, Van Loveren HR (1999) Primary lymphoma of Meckel’s cave mimicking trigeminal schwannoma: case report. Neurosurgery 44:859–862 (discussion 862–863)
Inatomi Y, Inoue T, Nagata S et al (1998) Trigeminal neuralgia caused by metastasis of malignant lymphoma to the trigeminal nerve: a case report. No Shinkei Geca 26:401–405
Rubinstein MK (1969) Cranial mononeuropathy as the first sign of intracranial metastases. Ann Intern Med 70:49–54
Moris G, Perez-Pena M, Miranda E et al (2005) Trigeminal mononeuropathy: First clinical manifestation of breast cancer. Eur Neurol 54:212–213
Theuer S, Krayenbuhl N, Scheffel H et al (2007) Metastases in Meckel’s cave. A challenge of differential diagnosis. Clin Neuroradiol 17:41–47
Quinones-Hinojosa A, Chang EF, Khan SA et al (2003) Isolated trigeminal nerve sarcoid granuloma mimicking trigeminal schwannoma: case report. Neurosurgery 52:700–705
Seol JG, Loevner LA, O’Malley BW Jr et al (2009) Inflammatory pseudotumor of the trigeminal nerve: a neoplastic mimic you do not want to miss. AJNR Am J Neuroradiol 30:1941–1943
Lee JH, Lee BH, Choe DH et al (1998) Magnetic resonance imaging of brain metastases. Is T2-hypointensity a valid sign for adenocarcinoma? Int J Neuroradiol 4:263–267
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Cerase, A., Brindisi, L., Lazzeretti, L. et al. Lung cancer presenting with trigeminal neuropathy. Neurol Sci 32, 927–931 (2011). https://doi.org/10.1007/s10072-011-0577-5
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DOI: https://doi.org/10.1007/s10072-011-0577-5