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Synergistic effect of Korean red ginseng and Pueraria montana var. lobata against trimethyltin-induced cognitive impairment

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A Correction to this article was published on 12 June 2018

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Abstract

Many edible plant extracts exhibit biological activities. For example, the ethanol extract of Pueraria montana var. lobata (P. montana) inhibits acetylcholinesterase (AChE), and red ginseng is well known for promoting health. In this study the authors investigated the synergistic effect of P. montana and red ginseng extracts on AChE activity in vitro and in mouse brain tissues and trimethyltin (TMT)-induced cognitive impairment in a mouse model of TMT-induced neurodegeneration. A diet containing a mixture of P. montana and red ginseng extracts reversed learning and memory impairments in Y-maze and passive avoidance behavioral tests. In addition, the mixture inhibited AChE activity and lipid peroxidation synergistically.

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  • 12 June 2018

    In the original version of these 14 articles the reference list was unfortunately not represented according to the journal’s new bibliographical style, which should have been implemented from January 2018.

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Acknowledgements

This work was supported by a Korea University Grant.

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Authors and Affiliations

  1. Department of Food and Biotechnology, Korea University, 612 College of Life Sciences, Green Campus, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea

    Young-Min Seo, Chan Kyu Park, Min Chul Gim & Dong-Hoon Shin

  2. Laboratory of Product Development, R&D Headquarters, Korea Ginseng Corporation, Daejeon, 34128, Republic of Korea

    Young-Min Seo

  3. Functional Food Research Center, Korea University, Seoul, 02841, Republic of Korea

    Soo Jung Choi

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  1. Young-Min Seo
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Correspondence to Dong-Hoon Shin.

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Seo, YM., Choi, S.J., Park, C.K. et al. Synergistic effect of Korean red ginseng and Pueraria montana var. lobata against trimethyltin-induced cognitive impairment. Food Sci Biotechnol 27, 1193–1200 (2018). https://doi.org/10.1007/s10068-018-0362-9

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