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The effects of platelet-rich plasma injection in knee and hip osteoarthritis: a meta-analysis of randomized controlled trials

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Abstract

Objective

We conducted this updated meta-analysis to evaluate the effects of PRP in patients with knee or hip OA.

Method

PubMed, Embase, and Web of Science were searched to identify randomized controlled trials (RCTs) that compared the efficacy of PRP with other intra-articular injections. The outcomes of interest included Western Ontario and McMaster (WOMAC), Knee Injury and Osteoarthritis Outcome Score (KOOS), Visual Analog Scale (VAS), Harris Hip Score (HHS), and International Knee Documentation Committee (IKDC).

Results

Twenty-four RCTs with 21 at knee OA and three at hip OA were included in this meta-analysis. The PRP injections significantly improved the WOMAC score, VAS score, IKDC score, and HHS score as compared with comparators. The WOMAC pain, stiffness, and physical function scores were also significantly better in the PRP group than in the control group. Most of the evaluated parameters that favored PRP were observed in knee OA but not in hip OA, at short-term (at 1, 2, 3, 6, 12 months) but not long-term follow-up (at 18 months), in RCTs with low risk of bias.

Conclusions

Intra-articular PRP injection provided better effects than other injections for OA patients, especially in knee OA patients, in terms of pain reduction and function improvement at short-term follow-up.

Key Points

• This updated meta-analysis, based on great sample size and high-quality studies, evaluates the effects of PRP in patients with knee or hip OA.

• Intra-articular PRP injection provided better effects than other injections for OA patients.

• Most of the evaluated parameters that favored PRP were observed in knee OA at short term (at 1, 2, 3, 6, 12 months).

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Department of Emergency, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China

    Yujie Dong

  2. Department of Radiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China

    Butian Zhang & Jiajing Zhu

  3. Department of Obstetrics and Gynecology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China

    Qi Yang

  4. Department of Plastic and Reconstruction Surgery, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun, 130033, Jilin, China

    Xiaojie Sun

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  1. Yujie Dong
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  2. Butian Zhang
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YD and XS contributed to the study design; all authors collected the data and performed the data analysis; all authors prepared the manuscript.

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Electronic supplementary material

Supplementary figure 1

Meta-regression of the total WOMAC score with age. (PNG 425 kb)

High Resolution Image (TIF 17794 kb)

Supplementary figure 2

Meta-regression of the total WOMAC score with male sex. (PNG 472 kb)

High Resolution Image (TIF 22942 kb)

Supplementary figure 3

Meta-regression of the total WOMAC score with BMI. (PNG 353 kb)

High Resolution Image (TIF 17794 kb)

Supplementary figure 4

Meta-regression of the total WOMAC score with grade of OA. (PNG 483 kb)

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Dong, Y., Zhang, B., Yang, Q. et al. The effects of platelet-rich plasma injection in knee and hip osteoarthritis: a meta-analysis of randomized controlled trials. Clin Rheumatol 40, 263–277 (2021). https://doi.org/10.1007/s10067-020-05185-2

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