Anti-tubulin-α-1C autoantibody in systemic lupus erythematosus: a novel indicator of disease activity and vasculitis manifestations

  • Xiaozhen Zhao
  • Yongjing Cheng
  • Yuzhou Gan
  • Rulin Jia
  • Lei Zhu
  • Xiaolin Sun
Original Article
  • 32 Downloads

Abstract

A variety of autoantibodies has been involved in the pathogenesis of systemic lupus erythematosus (SLE), some of which are well known and applied as disease biomarkers. This study aimed to determine the prevalence of a novel autoantibody, anti-tubulin-α-1C, in patients with SLE and investigate its clinical significance. Anti-tubulin-α-1C autoantibody levels were determined by enzyme-linked immunosorbent assay (ELISA) in 128 SLE patients, 38 primary Sjögren’s syndrome (pSS) patients, and 106 healthy controls (HCs).White blood cell (WBC) count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), IgM, IgG, C3, C4, RF, ANA, dsDNA, Sm, AnuA, aCL, anti-SSA, and anti-SSB were measured by standard laboratory techniques. SLE Disease Activity Index (SLEDAI) was evaluated accordingly. Anti-tubulin-α-1C antibody levels were significantly increased in SLE patients. Elevated anti-tubulin-α-1C were correlated with higher levels of SLEDAI, increased titers of anti-Sm antibody, and decreased titers of anti-dsDNA antibody and significantly associated with cutaneous and mucosal vasculitis and milder renal involvement. Anti-tubulin-α-1C may become a novel biomarker indicative of active vasculitis in SLE and could be applied in future clinical practice.

Keywords

Anti-tubulin-α-1C Autoantibody Systemic lupus erythematosus 

Notes

Compliance with ethical standards

The study was approved by the Ethics Committee of Peking University People’s Hospital according to the declaration of Helsinki with the following reference number: 2015PHB219-01. All patients had been informed and signed the consent for the participation in this study.

Disclosures

None.

Supplementary material

10067_2018_4024_MOESM1_ESM.pdf (187 kb)
ESM 1 (PDF 187 kb).

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Copyright information

© International League of Associations for Rheumatology (ILAR) 2018

Authors and Affiliations

  • Xiaozhen Zhao
    • 1
    • 2
  • Yongjing Cheng
    • 3
  • Yuzhou Gan
    • 1
    • 2
  • Rulin Jia
    • 1
    • 2
  • Lei Zhu
    • 1
    • 2
  • Xiaolin Sun
    • 1
    • 2
  1. 1.Department of Rheumatology and ImmunologyPeking University People’s HospitalBeijingChina
  2. 2.Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)BeijingChina
  3. 3.Department of Rheumatology and ImmunologyBeijing HospitalBeijingChina

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