Skip to main content
SpringerLink
Log in

Antiphospholipid antibodies, steroid dose, arterial hypertension, relapses, and late-onset predict organ damage in a population of Colombian patients with systemic lupus erythematosus

  • Original Article
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

Organ damage predicts mortality, increased accrual of detriment, and poor quality of life in systemic lupus erythematosus patients. The objective of this study is to determine the damage-free survival and its predictive factors in a population of Colombian subjects. The method used in this study is the retrospective follow-up of a cohort; damage was measured with SLICC/ACR index. Predictors of impairment were assessed by logistic regression and survival analysis. One hundred sixty-one individuals were included; 28.9% suffered damage, primarily neuropsychiatric, renal, and vascular. Arterial hypertension, antiphospholipid antibodies, prednisone dose, and number of relapses were all predictors of detriment. Onset after age 50 and daily prednisone dose higher than 7.5 mg determined earlier occurrence of damage.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Uribe A, McGwin G Jr, Reveille J, Alarc or n GS (2004) What have we learned from a 10-year experience with LUMINA (lupus in Minories nature versus nurture) cohort? Autoimmun Rev 3(4):321–329

    Article  PubMed  Google Scholar 

  2. Cheg M, Chiew HJ, Liu Y, Ho RC (2012) Global trend of survival and damage of systemic lupus erytematosus: meta-analysis and meta-regression of observational studies from 1950 to 2000. Without Arthritis Rheum 41(6):830–839

    Google Scholar 

  3. Urowitz MB, Gladman DD, Tom BD, Iba ñ and z D, Farewell VT (2008) Changing patterns in mortality and disease outcomes for patients with systemiclupus erythematosus. J Rheumatol 35:2152–2158

    Article  PubMed  Google Scholar 

  4. Moss KE, Ioannaou And SM Sultan, HAQ I, Isenberg D. (2002) Outcome in a cohort of 300 patients with systemic lupus erythematosus attending todedicate clinic for ever two decades. Ann Rheum Dis 61(5):409–413

  5. Doria A, Iaccarino L, Ghirardello A et al (2006) Long-term prognosis and causes of death in systemic lupus erythematosus. Am J Med 119:700–706

    Article  PubMed  Google Scholar 

  6. Wang C, May NE, Fortin PR (2001) The relationship between health related quality of life and disease activity and damage in lupus erythematosussistemkic. J Rheumatol 28(3):525–532

    CAS  PubMed  Google Scholar 

  7. Hanly JG (1997) Disease activity, cumulative damage and quality of life in systemic lupus erythematosus: result of a cross-sectional study. Lupus 6(2):243–247 57

    Article  CAS  PubMed  Google Scholar 

  8. Nossent J, Cikes N, Kiss E, Marchesoni A (2007) Current causes of death in systemic lupus erythematosus in Europe 2000–2004: relation to disease activity and damage accrual. Lupus 16(5):309–317

    Article  CAS  PubMed  Google Scholar 

  9. Chambers SI, Allen E, Rahman A, Isenberg D (2009) Damage and mortality in a group of British patients with systemic lupus erythematosus followed up to ten years. Rheumatology 48(6):673–675

    Article  PubMed  Google Scholar 

  10. Rhaman P, Gladman DD, Urowitz MB, Hallet D, Tan LS (2001) Early damage as measured by SLICC/ACR damage index is a predictor of mortality in systemic lupus erythematosus. Lupus 10(2):93–96

    Article  Google Scholar 

  11. Yee CS, Hussein H, Skan J, Bowman S, Situnsayake D, Gordon C (2003) Association of damage with antibody profile, age, race, sex and disease systemic lupus erythematosus in duration. Rheumatology 42(2):276–279

    Article  CAS  PubMed  Google Scholar 

  12. Ruiz Irastroza G, Egurvide MV, Mart í nez Berriotxoa A, Ugalde J, Aguirre C (2004) Antiphospholipid antibodies predict early damage in patients with systemic lupus erythematosus. Lupus 13(12):900–905

    Article  Google Scholar 

  13. Vil to LM, Molina MJ, Mayor AM, Peredo RA, Santella ML, Vil to S (2006) Clinical and prognostic value of autoantibodies in Puerto Ricans Withsystemic lupus erythematosus. Lupus 15(12):892–898

    Article  Google Scholar 

  14. Ugarte-Gil M, Acevedo-V to squez E, Alarc or n GS, Pastor-Asurza CA, Alfaro-Lozano JL, Cucho-Venegas JM et al. The number of flares patients experience impacts on damage systemic lupus erythematosus accrual in: data from a multiethnic Latin American cohort. Ann Rheum Dis 2015; 74(6): 1019–1023.

  15. Conti F, Ceccarelli F, Perricone C, Leccese I, Massaro L, Pacucci VA et al (2016) The Chronic systemic lupus erythematosus damage is driven by flares, glucocorticoids and antiphospholipid antibodies: results from a monocentric cohort. Lupus 25(7):719–726

    Article  CAS  PubMed  Google Scholar 

  16. Shinjo S, Bonfa E, Wojdyla D, Borba E, Ramirez LA, Scherbarth H et al (2010) Antimalarial treatment may have a time-dependent effect on lupus survival: data from a multinational Latin American inception cohort. Arthritis Rheum 62(3):855–862

    Article  CAS  PubMed  Google Scholar 

  17. Maddison P, Farewell P, Isenberg D, Aranow C, Bae SC, Barr S et al (2002) The rate and pattern of organ damage in lateral onset systemic lupus erythematosus. J Rheum 29(5):913–917

    PubMed  Google Scholar 

  18. Toloza SM, Roseman JM, Alarc or n GS, McGwin G, Uriube SA, Fessler B et al (2004) Systemic lupus erythematosus in a multiethnic US cohort(LUMINA): XXII. Predictors of time to occurrence of initial damage. Arthritis Rheum 50(10):3177–3186

    Article  PubMed  Google Scholar 

  19. Nossent J, Rozman B, Pokorny G, Vlachoyiannopoulos P, Olessinka M, Marchesoni A et al (2010) Disease activity and damage accrual during the early course in a multinational inception cohort of patient with systemic lupus erythematosus. Lupus 19(8):949–956

    Article  CAS  PubMed  Google Scholar 

  20. Bombardier C, Gladman DD, Urowitz MB, Caron D, Chang CH, Austin A, Bell A et al (1992) Derivation of the SLEDAI. A disease activity index patients for lupus. The Committee on Prognosis Studies in SLE. Arthritis Rheum 35(6):630–640

    Article  CAS  PubMed  Google Scholar 

  21. Gladman D, Ginzler E, Goldsmith C et al (1992) Systemic lupus international collaborative clinics: development of a damage systemic lupuserythematosus in index. J Rheumatol 19(3):1820–1821

    CAS  PubMed  Google Scholar 

  22. Bandeira M, Buratti S, Bartoli M, Gasparini C, Breda L, Pistorio A et al (2006) Relationship between damage accrual, disease flares and cumulative drug therapies in juvenile—onset systemic lupus erythematosus. Lupus 15(8):515–520

    Article  CAS  PubMed  Google Scholar 

  23. Reveille J, Bartolucci A, Alarcon GS (1990) Prognosis in systemic lupus erythematosus. Negative impact of increasing age onset, black race and thromobocytopenia as well as causes of death. Arthritis Rheum 33(1):37–48

    Article  CAS  PubMed  Google Scholar 

  24. Urowitz MB, Gladman DD, Iba ñ ez D, Fortin S, Bae SC, Gordon C et al (2012) Evolution of disease burden over five years in a multicenter inception systemic lupus erythematosus cohort. Arthritis Care Res (Hoboken) 64(17):132–137

    Article  CAS  Google Scholar 

  25. Gladman DD, Urowitz MB, Rhaman P, Ib ez aN D, Tam LS (2003) Accrual of organ damage over time in patients with systemic lupus erythematosus. J Rheumatol 30(9):1955–1599

    PubMed  Google Scholar 

  26. Stoll T, Seifert B, Isenberg DA (1996) SLICC/ACR damage index is valid and renal and pulmonary organ score are predictors of severe outcome in patients with systemic lupus erythematosus. Br J Rheumatol 35(3):248–254

    Article  CAS  PubMed  Google Scholar 

  27. Cassano G, Roverano S, Patras S, Bellomio V, Lucero E, Berman A et al (2007) Accrual of organ damage patients over time in Argentina with systemic lupus erythematosus: a multi-centre study. Clin Rheum 26(12):2017–2022

    Article  Google Scholar 

  28. Nossent JC (1998) SLICC/ACR damage index in African-Caribbean patients with systemic lupus erythematosu: changes and relationship to disease activity, corticosteroid therapy and prognosis. J Rheumatol 25(4):654–659

    CAS  PubMed  Google Scholar 

  29. Ruiz Arruza I, Ugarte A, Cabezas Rodriguez I, Medina J, Moran M, Ruiz-Irastorza G (2014) Glucocorticoids and irreversible damage in systemic lupus erythematosus. Rheumatology 53(8):1470–1476

    Article  CAS  PubMed  Google Scholar 

  30. Zonana-Nacach A, Barr SD, Magder LS, Petri MA (2000) Systemic lupus erythematosus in damage and its association with corticosteroids. ArthritisRheum 43(8):1801–1808

    Article  CAS  Google Scholar 

  31. Petri M (1995) Musculoskeletal complications of systemic lupus erythematosus in the John Hopkins lupus cohort: an update. Arthritis Care Res 8(1):137–145

    Article  CAS  PubMed  Google Scholar 

  32. Brunner HI, Silverman ED, To T, Bombardier C, Feldman BM (2002) Risk factors for damage in childhood-onset systemic lupus erythematosus: cumulative disease activity and medication use predict illness damage. Arthritis Rheum 46(2):436–444

    Article  PubMed  Google Scholar 

  33. Mikdashi J, Handwerger B (2004) Predictors of neuropsychiatric systemic lupus erythematosus in damage: data from the Maryland lupus cohort. Rheumatology 43(12):1555–1560

    Article  CAS  PubMed  Google Scholar 

  34. Ruiz-Irastorza G, Egurbide MV, Ugalde J, Aguirre C (2004) High impact of antiphospholipid syndrome on irreversible organ damage and survival of patients with lupus erythematosus systemic. Arch Int Med 164(1):77–82

    Article  Google Scholar 

  35. Stoll T, Sutclife N, Mach J, Klaghofer R, Isenberg DA (2004) Analysis of the relationship between disease activity and damage in patients with lupuserythematosus systemic—a 5 year prospective study. Rheumatology 43(8):1039–1044

    Article  CAS  PubMed  Google Scholar 

  36. Ugarte-Gil M, Acevedo-V to squez E, Alarc or n GS, Pastor-Asurza CA, Alfaro-Alfaro-Lozano JL, Cucho-Venegas JM et al. The number of flares patients experience impacts on damage systemic lupus erythematosus accrual in: data from a multiethnic Latin American cohort. Ann Rheum Dis 2015; 74 (6): 1019–1023.

  37. Appenzeller S, Pereira DA, Costallat LTL (2008) Greater accrual damage in lateral onset systemic lupus erythematosus: a long-term follow-up study. Lupus 17(11):1023–1028

    Article  CAS  PubMed  Google Scholar 

  38. Catoggio LJ, Soriano ER, Imamura PM, Wojdyla D, Jacobelli S, Massardo L et al (2015) Lateral onset systemic lupus erythematosus in Latin-Americans: a distinct subgroup? Lupus 24(8):788–795

    Article  CAS  PubMed  Google Scholar 

  39. Bertoli AM, Alarcon GS, Calvo-Al Appen J, Fernandez to M, Vil to LM, Reveille JD, LUMINA study group (2006) Systemic lupus erythematosus in a multiethnic US cohort. Arthritis Rheum 54(5):1580–1587

    Article  PubMed  Google Scholar 

  40. Thaner M, Hern to n MA, Zhang Y, Cotter D, Petri MA (2009) Prednisone, lupus activity and permanent organ damage. J Rheumatol 36(3):560–564

    Article  Google Scholar 

  41. Santos MJ, Vinegar F, Nero P, Barcelos F, Barcelos A, Rodrigues A et al (2009) Predictors of damage progression in Portuguese patients with systemic lupus their erythematosus. Ann N Y Acad Sci 1173(1):822–828

    Article  PubMed  Google Scholar 

  42. Estévez-Del Toro M, Chico-Capote A, Hechavarría H, Jiménez-Paneque R, Kokuina E (2010) Daño en pacientes cubanos con lupus eritematoso sistémico: relación con características de la enfermedad. Reumatol Clin 6(1):11–15

Download references

Acknowledgements

The authors acknowledge the Hospital Pablo Tobón Uribe Hospital and Universidad CES.

Author information

Authors and Affiliations

  1. Rheumatology Department, Hospital Pablo Tobón Uribe, Calle 78B 69 - 240, Medellin, Colombia

    Luis F Pinto-Peñaranda, C. Muñoz-Grajales, A. F. Echeverri Garcia & J. D. Márquez-Hernández

  2. Rheumatology Section, Clinica Universitaria Universidad Pontificia Bolivariana, Medellin, Colombia

    C. J. Velásquez-Franco & M. A. Mesa-Navas

  3. Internal Medicine Department, Hospital Pablo Tobon Uribe, Medellin, Colombia

    M. Zuluaga Quintero

  4. Hospital General de Medellin, Art Medica, Medellin, Colombia

    S. Herrera-Uribe

Authors
  1. Luis F Pinto-Peñaranda
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Muñoz-Grajales
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. F. Echeverri Garcia
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. J. Velásquez-Franco
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. A. Mesa-Navas
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. Zuluaga Quintero
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. S. Herrera-Uribe
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. J. D. Márquez-Hernández
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Luis F Pinto-Peñaranda.

Ethics declarations

The research did not represent any risk for the patients and was approved by the Ethics committees of the Hospital Pablo Tobón Uribe and Universidad CES.

Disclosures

None.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pinto-Peñaranda, L.F., Muñoz-Grajales, C., Echeverri Garcia, A.F. et al. Antiphospholipid antibodies, steroid dose, arterial hypertension, relapses, and late-onset predict organ damage in a population of Colombian patients with systemic lupus erythematosus. Clin Rheumatol 37, 949–954 (2018). https://doi.org/10.1007/s10067-017-3927-8

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-017-3927-8

Keywords

Search

Navigation