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IRAK2 is associated with susceptibility to rheumatoid arthritis

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Abstract

This study was performed to investigate the association of the single nucleotide polymorphisms of interleukin-1 receptor-associated kinase 2 (IRAK2) rs3844283 and rs708035 with rheumatoid arthritis (RA). IRAK2 rs3844283 and rs708035genotyping was determined by mutagenically separated PCR with specifically designed primers in a cohort of 222 (30 men, 192 women, mean age 49 years) adult RA patients and 224 matched controls. IRAK2 rs3844283 C allele was detected in 66% of RA patients and 74% of controls. The CC genotype was the most frequent genotype in both RA patients (45.5%) and the controls (56.3%). The G allele was found to be associated with RA susceptibility (OR = 1.47, 95% CI = 1.10–1.96, p = 0.008). The GG genotype was found to be associated with RA in the co-dominant and the dominant models (OR = 2.03, 95% CI = 1.08–3.81, p = 0.042 and OR = 1.54, 95% CI = 1.06–2.23, p = 0.023, respectively). IRAK2 rs708035 was found not to be in the Hardy-Weinberg equilibrium. The hyperfunctional IRAK2 rs708035 A allele was more frequent in RA patients than in controls (69.9 versus 62.2%, respectively, p = 0.015). Moreover, IRAK2 rs708035 and IRAK2 rs3844283 were in linkage disequilibrium and the GA haplotype was significantly more frequent in RA patients than in controls (p = 0.034). This study for the first time ever reports the association of IRAK2 rs3844283, IRAK2 rs708035, and the corresponding haplotypes with RA. Functional studies are recommended to elucidate the risk posed by the GA haplotype for the development of RA.

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Authors and Affiliations

  1. Laboratory of Immunology, Research Unit UR 807, Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia

    Hana Ben Hassine, Rim Sghiri, Elyes Chabchoub, Asma Boumiza, Foued Slama & Ramzi Zemni

  2. Department of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia

    Rim Sghiri, Zahid Shakoor & Adel Almogren

  3. Department of Rheumatology, Farhat Hached Hospital, Sousse, Tunisia

    Khadija Baccouche & Elyes Bouajina

  4. Mondor Institute of Biomedical Research, U955, team 15, Henri Mondor Hospital, Créteil, France

    Christina Mariaselvam & Ryad Tamouza

Authors
  1. Hana Ben Hassine
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  2. Rim Sghiri
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  3. Elyes Chabchoub
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  4. Asma Boumiza
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  6. Khadija Baccouche
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  9. Christina Mariaselvam
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  10. Ryad Tamouza
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  11. Elyes Bouajina
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  12. Ramzi Zemni
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Corresponding author

Correspondence to Rim Sghiri.

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This study was approved by Farhat Hached University Hospital ethics committee. Participants were enrolled in the study after obtaining their informed consent.

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Hassine, H.B., Sghiri, R., Chabchoub, E. et al. IRAK2 is associated with susceptibility to rheumatoid arthritis. Clin Rheumatol 37, 927–933 (2018). https://doi.org/10.1007/s10067-017-3906-0

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  • DOI: https://doi.org/10.1007/s10067-017-3906-0

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