Clinical Rheumatology

, Volume 37, Issue 4, pp 1027–1035 | Cite as

Clinical characteristics of autoimmune rheumatic disease-related organizing pneumonia

  • Xin Dong
  • Yi Zheng
  • Li Wang
  • Wen-hui Chen
  • Yun-gang Zhang
  • Qiang Fu
Original Article


To study the clinical characteristics of autoimmune rheumatic disease-related organizing pneumonia (AIRD-OP), the clinical presentation, radiological findings, treatment, and outcome of AIRD-OP patients were analyzed, in comparison with patients with cryptogenic organizing pneumonia (COP). A total of 131 OP patients were identified, including 57 cases of AIRD-OP, 35 cases of COP, and 39 cases of other disease-related OPs. Among AIRD-OP patients, 36 (63%) presented the symptoms of OP at onset. The primary disease of AIRDs included Sjogren’s syndrome (38%), polymyositis/dermatomyositis (23%), rheumatoid arthritis (23%), and undifferentiated AIRD. Compared with COP patients, the prevalence of patients having cough and malaise at baseline was significantly lower (54.4 vs 82.9%, P < 0.05; 49.1 vs 70.6%, P < 0.05), and the signs of moist rales and crackles were more common in AIRD-OP patients (54.4 vs 32.4%, P < 0.05; 49.1 vs 26.5%, P < 0.05). Lung function (TLC%, FVC%) was more significantly reduced in AIRD-OP patients (72 vs 97%, P < 0.05;75 vs 96%, P < 0.05). The dosage of corticosteroids prescribed was significantly higher in AIRD-OP patients (44 vs 37 mg/day, P < 0.05). The complete recovery rate was slightly lower in AIRD-OP patients (22.2 vs 29%, P > 0.05) with a tendency towards higher recurrence rate in AIRD-OP patients (32.7 vs 14.3%, P < 0.05). AIRD-OP may be the most common cause of OP. OP can be the initial presentation of AIRD. Compared with COP patients, AIRD-OP patients are characterized with occult onset but more severe lung involvement and higher recurrence rate.


Autoimmune rheumatic diseases Organizing pneumonia 



Xin Dong not only collected the data and wrote the manuscript but also prepared the figures. Besides, Yi Zheng supervised the study.

Compliance with ethical standards




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Copyright information

© International League of Associations for Rheumatology (ILAR) 2017

Authors and Affiliations

  1. 1.Department of Rheumatology, Beijing Chao-yang HospitalCapital Medical UniversityBeijingChina
  2. 2.Department of RadiologyBeijing Chao-yang HospitalBeijingChina
  3. 3.Department of RespirationBeijing Chao-yang HospitalBeijingChina
  4. 4.Department of PathologyBeijing Chao-yang HospitalBeijingChina

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