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Noninvasive evaluation of cardiac autonomic modulation in children with primary Raynaud’s phenomenon: a controlled study

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Abstract

This study aimed to objectively evaluate autonomic nervous function in children with primary Raynaud’s phenomenon (PRP). Thirty-two children with PRP and 30 healthy subjects were included in the study. We analyzed heart rate variability (HRV) in the time domain by the following six standard time-domain measures: standard deviation of all normal R-R intervals during 24 h (SDNN), standard deviation of all normal R-R intervals for all 5-min segments (SDNNi), standard deviation of the average normal R-R intervals for all 5-min segments (SDANN), root mean square of the successive normal R-R interval difference, percentage of successive normal R-R intervals longer than 50 ms, and triangular index (integral of the density distribution of NN intervals divided by the maximum of the density distribution). The mean heart rate throughout 24 h was significantly higher in the PRP group than in the control group (p = 0.001). Although heart rate during the activity period was not significantly different from that during the night period, it was higher in the PRP group than in the control group (p = 0.002). In children with PRP, HRV analysis showed significantly lower values of SDNN (p = 0.01), SDNNi (p = 0.005), SDANN (p = 0.02), and HRV triangular index (p = 0.02) compared with the control group. HRV analysis for sympathovagal balance demonstrated a preponderance for the sympathetic component in patients with PRP. We conclude that all time-domain parameters evaluated in HRV analysis are significantly lower in children with PRP than in healthy subjects.

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Authors and Affiliations

  1. Department of Pediatric Cardiology, Cumhuriyet University, School of Medicine, Sivas, Turkey

    Mehmet Burhan Oflaz

  2. Department of Pediatric Cardiology, Yuzuncu Yil University, School of Medicine, Van, Turkey

    İbrahim Ece

  3. Department of Pediatric Cardiology, Mersin Children Hospital, Mersin, Turkey

    Ayşe Esin Kibar

  4. Department of Pediatric Cardiology, Ataturk Hospital, Balikesir, Turkey

    Şevket Ballı

  5. Department of Pediatrics, Cumhuriyet University, School of Medicine, Sivas, Turkey

    Demet Alaygut, Ahmet Sami Guven & Fatih Bolat

  6. Department of Pediatric Immunology and Rheumatology, Cumhuriyet University, School of Medicine, Sivas, Turkey

    Fatma Duksal & Ömer Cevit

  7. Department of Pediatrics, Cumhuriyet University Faculty of Medicine, Cumhuriyet Universitesi Arastirma ve Uygulama Hastanesi, Kampus, 58140, Sivas, Turkey

    Mehmet Burhan Oflaz

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  1. Mehmet Burhan Oflaz
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  2. İbrahim Ece
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Correspondence to Mehmet Burhan Oflaz.

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Oflaz, M.B., Ece, İ., Kibar, A.E. et al. Noninvasive evaluation of cardiac autonomic modulation in children with primary Raynaud’s phenomenon: a controlled study. Clin Rheumatol 33, 71–75 (2014). https://doi.org/10.1007/s10067-013-2393-1

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  • DOI: https://doi.org/10.1007/s10067-013-2393-1

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