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Effect of aerobic training on plasma cytokines and soluble receptors in elderly women with knee osteoarthritis, in response to acute exercise

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Abstract

The aim of this study was to evaluate levels of interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), and soluble forms of the TNF-α receptor (sTNFR1 and sTNFR2) from plasma taken from the peripheral blood of elderly individuals presenting with osteoarthritis (OA) of the knee. These patients underwent aerobic treatment through the use of physical exercises. The study consisted of a longitudinal analysis of older individuals presenting clinical and radiographic diagnosis of knee OA that were submitted to 12 weeks of aerobic treatment. The individuals were evaluated during acute exercise or after chronic exercise. During acute exercise (walking slowly on the mat), blood samples of the patients were collected before, immediately after, and 30 min following the end of training. After chronic exercise (aerobic walking training, three times/week for 12 weeks), patient blood samples were obtained for comparison. Additionally, clinical and functional assessments (WOMAC test and 6-min walk) were performed at the end of all physical exercises. Plasma concentrations of cytokines and soluble receptors were measured by ELISA. Aerobic training increased the plasma concentration of sTNR1; however, it decreased the plasma concentration of sTNFR2, when compared with levels of resting patients. Acute exercise differentially affects the levels of sTNFR1 dependent on when the samples were taken, before and after aerobic training. However, the levels of sTNFR2 were not affected by training. For the population studied, we observed differences in the levels of sTNFR1 and sTNFR2 following acute and chronic exercise. Other additional factors, like the level of inactivity of the individual and the type of physical exercise that patients are exposed to, need to be considered as well. The variation in the levels of soluble receptors correlated with functional improvement; however, the inflammatory osteoarthritis markers (IL-6 and TNF-α) were unaffected by the walking exercises.

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Acknowledgments

The authors are grateful to the Brazilian Society of Physiology and Santa Casa de Caridade Hospital of Diamantina.

Financial support

This study was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), and the Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG).

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Authors and Affiliations

  1. Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil

    Wellington Fabiano Gomes, Ana Cristina Rodrigues Lacerda, Vanessa Amaral Mendonça, Arthur Nascimento Arrieiro, Sueli Ferreira Fonseca, Mateus Ramos Amorim, Etel Rocha-Vieira & Gustavo Eustáquio Alvim Brito-Melo

  2. Multicenter Post Graduation Program in Physiological Sciences, Brazilian Society of Physiology, Minas Gerais, Brazil

    Wellington Fabiano Gomes, Ana Cristina Rodrigues Lacerda, Vanessa Amaral Mendonça, Arthur Nascimento Arrieiro & Gustavo Eustáquio Alvim Brito-Melo

  3. Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil

    Antônio Lúcio Teixeira, Mauro Martins Teixeira, Aline Silva Miranda & Cândido Celso Coimbra

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  1. Wellington Fabiano Gomes
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Correspondence to Wellington Fabiano Gomes.

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Gomes, W.F., Lacerda, A.C.R., Mendonça, V.A. et al. Effect of aerobic training on plasma cytokines and soluble receptors in elderly women with knee osteoarthritis, in response to acute exercise. Clin Rheumatol 31, 759–766 (2012). https://doi.org/10.1007/s10067-011-1927-7

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  • DOI: https://doi.org/10.1007/s10067-011-1927-7

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