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Journal of Artificial Organs

, Volume 21, Issue 2, pp 215–219 | Cite as

Acetaminophen clearance during ex vivo continuous renal replacement therapies

  • Bridget A. Scoville
  • Vera Vulaj
  • Bruce A. Mueller
  • Gail M. Annich
  • Deborah S. Wagner
Original Article Artificial Kidney / Dialysis

Abstract

Intravenous acetaminophen is an adjuvant to opioid use in critically ill and surgical patients requiring continuous renal replacement therapy (CRRT). The objective of this study was to determine the ex vivo transmembrane clearance of intravenous acetaminophen during continuous hemofiltration and hemodialysis. Transmembrane clearance was assessed using a validated ex vivo bovine blood model for CRRT using an F8 or HF1400 hemodiafilter. Ultrafiltrate and dialysate flow rates were 1, 2, and 3 L/h. Urea and acetaminophen clearances were calculated and compared. Acetaminophen was readily cleared by continuous hemofiltration with both hemodiafilters. Acetaminophen clearance rates were 92–98% of ultrafiltrate production rates. Similarly, dialytic acetaminophen clearances approximated dialysate flow rates for both hemodiafilters. Acetaminophen is readily cleared by CRRT. Patients receiving CRRT and acetaminophen may require increased doses for adequate pain control.

Keywords

Intravenous acetaminophen Critical care Continuous renal replacement therapy Dialysisex vivo clearance 

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Copyright information

© The Japanese Society for Artificial Organs 2017

Authors and Affiliations

  1. 1.Saint Alexius Medical CenterHoffman EstatesUSA
  2. 2.University of Michigan College of PharmacyAnn ArborUSA
  3. 3.Department of Pediatric Critical CareHospital for Sick ChildrenTorontoCanada
  4. 4.Department of Pediatric Anesthesiology, C.S. Mott Children’s Hospital and Von Voigtlander Women’s HospitalUniversity of MichiganAnn ArborUSA

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